Extranodal NK/T-cell lymphoma, nasal type (angiocentric T-cell lymphoma): A review about the terminology

Abstract

Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a rare lymphoid neoplasm, which in the past has been grouped with a variety of granulomatous diseases. It is an aggressive non-Hodgkin’s type characterized clinically by aggressive, nonrelenting destruction of the midline structures of the palate and nasal fossa. Despite the malignant clinical course, histological diagnosis can be difficult because of extensive tissue necrosis and multiple biopsies that are often required and has an ominous prognosis, as the average survival rate is between 6 and 25 months as reported with a large number of Asian studies. Several American and European studies have shown similar results. This is the case report of a 60-year-old male patient who presented with nasal obstruction and foul smelling, ulcerative lesion over the palate of 6 months duration, which had been treated with antibiotics and anti-inflammatories without success. After performing a number of diagnostic tests, it was found histologically and confirmed by immunohistochemical analysis that the patient had an ENKL, nasal type (also known as angiocentric T-cell lymphoma).

Sinonasal Mass - A Diverse Clinicopathological Entity – An Experience in a Tertiary Care Centre in the North Eastern India

“…These tumours are found to be associated with Epstein Barr virus and the prodromal stage of the disease may have an indolent course that may last many years. 19,20,21 These tumours show positive immunostaining to CD3, CD56. 21,22 Olfactory neuroblastoma is a rare tumour.…”

“…19,20,21 These tumours show positive immunostaining to CD3, CD56. 21,22 Olfactory neuroblastoma is a rare tumour. Tural et al found only nineteen cases in a 24-year retrospective analysis.…”

Case study interpretation—new orleans: Case 3

“…It is more prevalent in Asian populations and native Americans of Central and South America (1)(2)(3)4). ENKTL is typically seen in adults but can occur in children as well (1)(2)(3). Approximately 70% of ENKTL are reported to be of NK cell origin (5).…”

“…ENKTL, nasal type, is a rare lymphoid neoplasm, representing approximately 1.5% of all lymphomas in the United States a (1-3). It is more prevalent in Asian populations and native Americans of Central and South America (1)(2)(3)4). ENKTL is typically seen in adults but can occur in children as well (1)(2)(3).…”

Tip of nose tuberculosis: A rare presentation of extra pulmonary tuberculosis

“…Histology of sarcoidosis demonstrates non caseating granulomas. Midline granuloma is a lethal malignant condition characterized by angiocentric and angiodestructive growth patterns with extensive mucosal ulceration and lymphomatous infiltrate (14,15). Many times the diagnosis is delayed and it may lead to further involvement of the adjacent structures and cosmetic disfigurement but fortunately in our patient there was a superficial ulcerative and crusting lesion over the tip of her nose which probably prompted her parents to seek early consultation and so based on clinical suspicion followed by histopathological confirmation with demonstration of epitheloid granulomas, necrosis and other supportive features suggestive of tuberculosis the patient was started on antitubercular chemotherapy.…”