Extranodal NK-T Cell Lymphoma, Nasal Type: Retrospective Analysis of Real-World Data

Bothra, Sneha; Bhandari, Pragya; Agrawal, Narendra; Tejwani, Narender; Ahmed, Rayaz; Khushoo, Vishvdeep; Mirgh, Sumeet

doi:10.1007/s12288-019-01195-6

Cited by 2 publications

(5 citation statements)

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“…This disease may occur in children but predominantly found in adults, with a mean age of 45 years. [ 5 10 ] Even though the age of presentation ranging from 19 to 80 years, both cases showed a lower age than the mean age reported. [ 10 ] Increased incidence is revealed in males.…”

Section: Discussionmentioning

confidence: 87%

“…[ 10 ] The correlation between ENKTL-NT and EBV is remarkably strong that it will give rise to suspicious diagnosis for cases with a lack of EBV detection by in situ hybridization. [ 3 5 ] Epstein–Bar virus is a gammaherpesvirus that has infected at least 90% of the world's adult population. Infected patients frequently remained asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…[ 10 14 ] Based on the WHO 2016 classification, distinguishing pathologic features of ENKTL-NT are typically CD3−, CD3+, CD56+, CD16±, and germline T-cell receptor; subset of T cell origin; and clonal EBV NK/T cells. [ 5 17 ] Besides, imaging studies may become helpful modalities to suggest a diagnosis of ENKTL-NT. Previous reports showed that some patients initially recognized through nasal and paranasal sinus destruction.…”

Section: Discussionmentioning

confidence: 99%

“…For patients with localized type ENKTL, chemoradiotherapy is preferred. [ 5 ] Besides, combined chemotherapy and l-asparaginase is considered to be better for disseminated type. [ 14 18 ] Other reports suggested using the regimen of radiation therapy (RT) combined with CHOP chemotherapy, using cyclophosphamide, doxorubicin, vincristine, and prednisone (RT-CHOP).…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 3 ] It usually presented as initial nonspecific features, including nasal obstruction, purulent discharge, epistaxis, which then progressed into destructive lesions. [ 1 4 5 6 7 ] Recently, tremendous literature has discussed the clinical features, diagnosis, treatment, and prognosis of ENKTL-NT, yet its early recognition remains perplexing. [ 8 ] Furthermore, patients with marked ocular symptoms are more likely to be misdiagnosed than those with nasal symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Two young patients with extranodal natural killer/T-cell non-Hodgkin lymphoma, nasal-type (ENKTL-NT) masquerading inflammatory processes: A case series

Anggraini

Mahyuddin

Siregar

2022

Taiwan J Ophthalmol

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Extranodal natural-killer/T-cell lymphoma (ENKTL) is a rare type of non-Hodgkin lymphoma. However, it is common in Asia and South America. ENKTL, nasal type (ENKTL-NT), predominantly presents initial unspecific clinical manifestations involving the nasal cavity and its adjacent structures. We present two cases to increase the awareness of the ENKTL-NT cases masquerading inflammatory processes. Although the main clinical feature is a rapidly progressive facial destruction, none of these patients experienced the mentioned complaint. Its various manifestations frequently lead to misdiagnosis and delayed treatment, particularly in those with marked ocular, not nasal symptoms. Our patients were previously diagnosed with inflammatory conditions, namely sinusitis, idiopathic orbital inflammation, dacryocystitis, and orbital cellulitis. The combined approach of chemotherapy and radiotherapy has been proposed as the treatment of choice. Both cases showed young adults treated with combined therapy, yet showing poor outcomes. Clinicians should be aware of its existence and have to consider ENKTL-NT as one of the differential diagnoses in sinonasal or orbital inflammatory cases with unusually rapid progression or unresponsive to treatment.

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Section: Discussionmentioning

confidence: 87%