Extranodal natural killer/T‐cell lymphoma, nasal type, in Senegal

Diallo, Moussa; Diop, Assane; Diatta, B.A.; Ndiaye, M.; Ortonne, Nicolas; Dieng, Mame Thierno

doi:10.1111/ijd.13921

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…Cases of ENKTCL-NT with massive midfacial destruction have been described in patients from India, Senegal, and South Africa. In support of this association, some of these cases were also identified in patients of poor nutritional status and illiteracy [27][28][29][30]. Studies from septentrional and sub-Saharan Africa show different geographic and racial features than those classically described for ENKTCL-NT.…”

Section: Discussionmentioning

confidence: 93%

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RETRACTED ARTICLE: Extranodal NK/T-Cell Lymphoma, Nasal Type in Guatemala: An 86-Case Series Emphasizing Clinical Presentation and Microscopic Characteristics

Sánchez‐Romero

Almeida

Henao

et al. 2019

Head and Neck Pathol

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Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a lymphoid malignancy that mainly affects the nasopharynx and is associated with the Epstein-Barr virus (EBV). Increased incidence is seen in some Latin American and Asian countries. In this study, we describe a case series of 86 Guatemalan patients with ENKTCL-NT from a single diagnostic head and neck center. We emphasize the distinctive clinical, microscopic, and immunohistochemical (IHC) features, as well as EBV positivity by in situ hybridization (ISH). Most of the patients (90.6%) were of Mayan descent and low socioeconomic status (SES). Males were more often affected than females, comprising 68.3% of cases. Patient age ranged from 8 to 71, with a mean of 34.7 years. All cases arose in the upper aerodigestive tract and mainly presented as a rapidly progressive, necrotizing midfacial process affecting the nasal, nasopharyngeal, sinonasal, palatal, and oropharyngeal structures. Microscopically, ENKTCL-NT showed a diffuse polymorphic and atypical lymphoid infiltrate. Angiocentric and angiodestructive growth patterns were present with associated necrosis. Peripheral hyaline necrosis of blood vessels was a histologic hallmark. The ISH and IHC profiles included positivity of EBV, LCA, CD3, CD45RO, CD30 (focal in 39.2%), granzyme-B, TIA-1, perforin (in 82.3%), and CD56 (in 83.7%). CD20 was negative, and the Ki-67 index ranged from 70 to 90%. In Guatemala, this lymphoma is strongly associated with people of low SES and indigenous ethnicity. When affected, the palatal mucosa provides the best site to obtain a representative biopsy. Since ENKTCL-NT is highly aggressive, it is extremely important to recognize the spectrum of clinical presentations and microscopic features in order to avoid misdiagnosis and treatment delay.

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Section: Discussionmentioning

confidence: 93%

“…Studies from septentrional and sub-Saharan Africa show different geographic and racial features than those classically described for ENKTCL-NT. This raises the possibility of an underestimated incidence in other underdeveloped countries [27,[30][31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Extranodal NK/T-Cell Lymphoma, Nasal Type in Guatemala: An 86-Case Series Emphasizing Clinical Presentation and Microscopic Characteristics

Sánchez‐Romero

Almeida

Henao

et al. 2019

Head and Neck Pathol

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“…Initially, 1998 records were retrieved from electronic databases and manual reference searches. After removing duplicates and the studies that did not meet the inclusion criteria, 61 articles (n = 271) were finally included (Figure ) 7,8,16,19,26–82 . After including 18 patients from the Asan Medical Center database, a total of 289 patients were identified.…”

Section: Resultsmentioning

confidence: 99%

Clinicopathological and prognostic study of primary cutaneous extranodal natural killer/T‐cell lymphoma, nasal type: A systematic review

Jung

Yang

Won

et al. 2021

The Journal of Dermatology

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Comprehensive studies of primary cutaneous extranodal natural killer/T‐cell lymphoma (PCENKTL) are scarce. The objectives of this study are to describe PCENKTL in terms of its clinical features, histopathology, immunophenotypes, and prognosis, and to analyze factors affecting patient survival outcomes. We searched four databases and include studies with extractable data. We also searched the Asan Medical Center database for cases of PCENKTL. We include a total of 289 patients. The mean age at diagnosis was 52.8 years and the female to male ratio was 1:1.2. The most common clinical morphology was a subcutaneous nodule, followed by ulceration. About half of the patients presented with disseminated skin lesions. The median overall survival was 12.0 months and the 5‐year survival rate was 22.0%. There was no correlation between the clinical morphology or the histopathological features of the skin lesions with the patient outcomes. Advanced TNM stage, a disseminated skin lesion, tumor location on the leg or trunk, the presence of B symptoms, and a high International Prognostic Index score were associated with a worse prognosis, and chemoradiotherapy was associated with a better survival outcome as compared with chemotherapy alone in univariable analyses. In multivariable analyses, only advanced TNM stage and tumor location on the leg were associated with a worse prognosis. In conclusion, PCENKTL is an aggressive cutaneous lymphoma and its prognosis is associated with TNM stage and tumor location.

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“…In these two regions of the world, it accounts for 10% of non-Hodgkin's lymphomas and 30% of extra-ganglionic lymphomas. It is less common in North America, Europe and Africa [7], [10], [11]. The starting point can be any extraganglionic organ or tissue, especially the upper aerodigestive tract (UADT), such as the nasal cavity and Waldeyer's ring.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal NK/T Cell Lymphoma, Nasal Type: Case Report and Literature Review

Chekrine

Bourhafour

Moustakbal

et al. 2023

EJMED

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Extranodal Natural Killer T-cell lymphoma, nasal type represent a rare and aggressive entity of the non-Hodgkin's lymphomas. Laryngeal localization is rare and has a poor prognosis. We report the case of a 66-year-old patient who consulted for dyspnea, dysphonia and dysphagia. Endoscopic examination revealed an endo-laryngeal lesion. Anatomopathological study with immunohistochemistry concluded to a peripheral T NK/T-cell lymphoma nasal type. The extension workup was without abnormalities. Induction chemotherapy without anthracyclines was administered followed by conformal radiotherapy with intensity modulation in arctotherapy. Significant advances have been made over the past decade including better clarification of clinical heterogeneity, more accurate classification using imaging modalities, establishment of new prognostic models, and sequential use of anthracycline-free radiotherapy and chemotherapy in early stages and risk-adapted first-line treatment strategies in advanced stages.

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Extranodal natural killer/T‐cell lymphoma, nasal type, in Senegal

Cited by 6 publications

References 22 publications

RETRACTED ARTICLE: Extranodal NK/T-Cell Lymphoma, Nasal Type in Guatemala: An 86-Case Series Emphasizing Clinical Presentation and Microscopic Characteristics

RETRACTED ARTICLE: Extranodal NK/T-Cell Lymphoma, Nasal Type in Guatemala: An 86-Case Series Emphasizing Clinical Presentation and Microscopic Characteristics

Clinicopathological and prognostic study of primary cutaneous extranodal natural killer/T‐cell lymphoma, nasal type: A systematic review

Laryngeal NK/T Cell Lymphoma, Nasal Type: Case Report and Literature Review

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