Extranodal Follicular Dendritic Cell Sarcoma

Youens, Kenneth E.; Waugh, Michael S.

doi:10.5858/2008-132-1683-efdcs

Cited by 46 publications

(32 citation statements)

References 25 publications

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“…Follicular dendritic cell sarcoma has a slight female predominance (1.2:1) and a wide patient age range for disease presentation, although it most often presents in the fifth decade of life. 2 The World Health Organisation classification of haematopoietic and lymphoid neoplasms includes FDCS in the group of histiocytic and dendritic cell neoplasms. 5 Because of the rarity of dendritic cell sarcoma (DCS), its clinical behaviour and optimal management has not been consolidated.…”

Section: Discussionmentioning

confidence: 99%

“…1 Follicular dendritic cells are immune accessory cells widely distributed in both nodal and extranodal lymphoid tissue, presenting antigens to B-lymphocytes. 2 Thus, uncontrolled proliferation of these cells affects lymph nodes, primarily of the mediastinum and cervical and axillary regions. 3 When primary extranodal disease occurs, the pharyngeal region is one of the preferred sites, in particular the tonsils.…”

Section: Introductionmentioning

confidence: 99%

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Not always ‘squame’: The rare entity of follicular dendritic cell sarcoma of the tonsil presenting with cervical nodal metastases

Brugman

Bruyn

Naidoo

et al. 2020

South African Journal of Radiology

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Although squamous cell carcinoma accounts for the overwhelming majority of head and neck malignant neoplasms, extranodal follicular dendritic cell sarcoma (FDCS) of the pharyngeal region can have a similar clinical presentation. The histopathological features of this rare entity have been described and emphasised in the literature. We present the case of a 65-year-old male patient with FDCS of the tonsil to illustrate the radiologic findings of FDCS and also highlight this infrequent but salient differential diagnosis for adult head and neck neoplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Not always ‘squame’: The rare entity of follicular dendritic cell sarcoma of the tonsil presenting with cervical nodal metastases

Brugman

Bruyn

Naidoo

et al. 2020

South African Journal of Radiology

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“…[ 12 , 25 ] The differential diagnosis include: sarcoma, Hodgkin disease, leiomyosarcoma, gastro-intestinal stromal tumor (GIST), and inflammatory pseudo-tumor. [ 8 , 26 , 27 ] According to IHC analyses, FDC sarcoma shows spindle tumor cells arranging in fascicular or storiform patterns, which are immuno-reactive for one or more FDC markers: CD21 (C3d receptor, positive in 93% of cases) and CD35 (C3b receptor, positive in 89% of cases). Other quite specific markers used are: R4/23 (63%), Ki-67 (5–50%), EMA (41%), Vimentin (61%), HLA-DR (57%), CD45 (21%), and S-100 protein (31%).…”

Section: Discussionmentioning

confidence: 99%

Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor with hepatic lymphoma history

Tao

Chen

et al. 2021

Medicine

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Rationale: Hepatic inflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) sarcoma is a very rare disease. Till now, only 19 cases were reported in the English literature. However, the coexistence of IPT-like sarcoma and non-Hodgkin lymphoma (NHL) in the same patient has never been reported. In this report, we presented a case of hepatic IPT-like FDC with hepatic NHL history of which both were successfully resected. Patient concerns: We reported a case of a 47-year-old male patient who presented with right upper abdominal discomfort. Nineteen years ago, he underwent liver resection of segment VII for hepatic NHL (B-cell lymphoma). He had a history of chronic hepatitis B virus infection. Serum alpha fetoprotein level was normal. However, imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe, he came back to the clinic because he was worried about a recurrence of the B-cell lymphoma. Diagnoses: Based on the patient's past medical history and magnetic resonance imaging results, and he was diagnosed as hepatocellular carcinoma or hepatic NHL preoperatively. Interventions: Right hemi-hepatectomy was performed on this patient. Outcomes: Histological report showed features of a mixture of chronic inflammatory cells and variable amounts of spindle cells. Also, immuno-histo-chemical studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs and strongly positive stainings with CD21 and CD35. The patient tolerated the surgery well, recovered smoothly and he was discharged on postoperative day 7 (day 7). The patient is still disease free after a follow-up of over 50 months. Conclusions: To our knowledge, this is the first report demonstrating hepatic IPT-like FDC sarcoma in a patient with primary hepatic NHL history. In regards to treatment, complete surgical resection should be performed and would acquire excellent long-term outcomes.

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“…By now, there are less than 100 cases of follicular dendritic cell tumors have been reported in the English literature [2,9]. The differential diagnosis includes Hodgkin's disease, sarcoma, leiomyosarcoma, gastrointestinal stromal tumor and in ammatory pseudotumor [10][11][12]. According to immunohistochemical analyses, the most commonly used FDC tumor markers include CD21 (C3d receptor, positive in 93% of cases) and CD35 (C3b receptor, positive in 89% of cases).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the liver with hepatic lymphoma history: a case report and literature review

Zhang

Wang

et al. 2020

Preprint

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BackgroundInflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) sarcoma of the liver is very rare and mostly occurs in females. Up to now, 19 cases were reported in the English literature. Surgical resection remains the preferred method for the management of this kind of tumor. Case presentationWe reported a case of a 47-year-old male patient who had hepatitis B virus infection history and presented with up-abdominal discomfort. He underwent liver resection of segment VII for hepatic non-hodgkin lymphoma (B-cell lymphoma) 19 years ago. Serum alpha fetoprotein was normal. Imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe and was diagnosed as HCC or hepatic lymphoma. Right hemihepatectomy was performed and the patient was disease free after a follow-up of 20 months. Histological feature showed a mixture of chronic inﬂammatory cells and variable amounts of spindle cells. Immunohistochemical studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs (EBER) and strongly positive staining with CD21 and CD35. A diagnosis of hepatic IPT-like FDC sarcoma was rendered. The coexistence of IPT-like sarcoma and non-Hodgkin’s lymphoma in same patient is extremely rare. He remains disease-free more than 40 months after surgical resection.ConclusionTo our knowledge, this is the first report to demonstrate hepatic IPT-like FDC sarcoma in a patient with primary hepatic non-hodgkin lymphoma history. Complete surgical resection should be pursued.

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Extranodal Follicular Dendritic Cell Sarcoma

Cited by 46 publications

References 25 publications

Not always ‘squame’: The rare entity of follicular dendritic cell sarcoma of the tonsil presenting with cervical nodal metastases

Not always ‘squame’: The rare entity of follicular dendritic cell sarcoma of the tonsil presenting with cervical nodal metastases

Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor with hepatic lymphoma history

Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the liver with hepatic lymphoma history: a case report and literature review

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