Extranasal extranodal NK/T cell lymphoma: A post‐transplantation lymphoproliferative disease

Abstract

Extranodal NK/T cell lymphoma (ENKTL) is a rare form of non‐Hodgkin lymphoma. It mostly occurs in the upper respiratory tract. Cutaneous involvement can be seen among the extranasal ENKTLs. After solid organ and haematopoietic stem cell transplantation, post‐transplantation lymphoproliferative disease because of immunosuppressive therapy is usually B cell‐derived; T and NK/T cell‐derived disease is rarely seen. A 43‐year‐old female patient who had renal transplantation 14 years ago presented with cutaneous ulceration and subcutaneous nodules located in the abdomen. The patient was diagnosed with ENKTL, nasal type. Although it is rare, ENKTL nasal type is a lymphoproliferative disease that should be considered in the differential diagnosis of ulcerated cutaneous tumoural lesions.

Primary Cutaneous Natural Killer/T-Cell Lymphoma

“…However, primary cutaneous PTLD tends to be of T-cell origin 4 . Posttransplant lymphoproliferative disorder of NK/T-cell origin is a very rare and serious disease that can involve both solid organ and bone marrow transplant patients 5 . Presentation of PTLD varies widely and is often nonspecific 6 .…”

“…4 Posttransplant lymphoproliferative disorder of NK/T-cell origin is a very rare and serious disease that can involve both solid organ and bone marrow transplant patients. 5 Presentation of PTLD varies widely and is often nonspecific. 6 Posttransplant lymphoproliferative disorder can involve many organ systems, including bone marrow, central nervous system, gastrointestinal tract, and skin.…”

Clinicopathological and prognostic study of primary cutaneous extranodal natural killer/T‐cell lymphoma, nasal type: A systematic review

“…Initially, 1998 records were retrieved from electronic databases and manual reference searches. After removing duplicates and the studies that did not meet the inclusion criteria, 61 articles (n = 271) were finally included (Figure ) 7,8,16,19,26–82 . After including 18 patients from the Asan Medical Center database, a total of 289 patients were identified.…”

Primary Cutaneous Extranodal Natural Killer (NK) T-Cell Lymphoma

“…ENKTL is typically CD2+, CD56+, cytoplasmic CD3ε+, EBER+ and usually TIA1+, Granzyme B+, and perforin+, while negative for CD4, CD5, CD8, and CD20. [ 5 ] Although CD8 is negative in most cases, a recent study demonstrated that CD8 was found to be positive in 20% cases of ENKTL. [ 2 ] The most common laboratory findings were hyperferritinemia, thrombocytopenia, hypertriglyceridemia, severe anemia, hypofibrinogenemia, and neutropenia,[ 3 ] according to the literature, blood, and bone marrow involvement were not found in many ENKTL cases.…”