Extramedullary Plasmacytomata of the Upper Respiratory Tract

Abstract

Extramedullary plasmacytomata may arise in any structure containing re-ticulo-endothelial tissue. Such tumors may be either isolated or the initial lesion of a generalized disseminated condition. Ideally, multiple involvement should be diagnosed at the presymptomatic stage; this may be possible by detecting variations in the immunoglobulins. Histologically, electron microscopy is advised to detect the plasma cell in the more undifferentiated case. Nine cases are reported. Two cases showed multiple involvement presenting with extramedullary plasmacytomata. A further case recurred locally many times but is still alive after 22 years. The remaining seven cases showed only isolated extramedullary plasmacytomata; of these, five were benign but in two, the tumor eroded bone locally. Those which subsequently developed multiple myelomata showed changes in the serum proteins, erythrocyte sedimentation rate (ESR) and radiologically, at approximately the same time. Surgical excision and/or radiotherapy was equally successful in those patients with localized disease.

Oral Lesions and Lymphoproliferative Disorders

“…Clinically [39–41], the plasmacytoma extraosseous is present as a sessile or pedunculated exophytic neoformation, circumscribed or infiltrative, ranging in color from red-purple to gray or yellow-white [42–50]. …”

Extramedullary plasmacytoma: rare neoplasm of parotid gland

“…In two-thirds of cases in the head and neck, EMP is located in the upper respiratory tract or oral cavity primarily in the nose, sinuses and nasopharynx region 2. Solitary EMP of the parotid gland is a rare condition among all head and neck EMPs 4.…”

“…Extramedullary plasmacytoma (EMP) most frequently arises in the upper aerodigestive tract. Booth et al in their review of 250 reported cases stated that primary EMP usually affect the head and neck region 2. SP of the parotid gland is a rare condition with the first case reported in 1965 3.…”

Endoscopic endonasal medial maxillectomy: case series

“…EMP is a neoplasm of the plasma cells arising in areas other than bone and bone marrow without any systemic signs of underlying multiple myeloma. The majority of EMPs occurs in the head and neck with a marked predilection for the nasal cavity and paranasal sinuses [15][16][17][18][19]. They are non-disseminating but locally aggressive [18].…”