Extramedullary Plasmacytoma of the Parotid Gland

Üstün, Melek; Ekıncı, Neşe; Payzın, Bahriye

doi:10.1159/000327648

Cited by 15 publications

(6 citation statements)

References 8 publications

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“…The electronic searches yielded 1143 articles (PubMed: 418, Web of Science: 292, Embase: 265, and Scopus: 168) and 82 studies reporting 102 individuals were included in this systematic review 17–98 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…A recent systematic review identified concordance rates higher than 64% for the smear and 77% for the cell‐block technique regarding diagnostic capability for the evaluation of intraosseous jaw lesions, including malignant lesions 16 . Despite several published reports on the cytopathological diagnosis of PCN, either in isolated manifestations (extramedullary or solitary bone plasmacytoma) or as a consequence of PCM, 17–98 there is a lack of compiled information investigating the agreement of cytopathological and histopathological findings, along with others ancillary cytological methods such as smears and cell blocks. In fact, FNAC represents a faster, cheaper and more diversified noninvasive diagnostic approach.…”

Section: Introductionmentioning

confidence: 99%

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Fine‐needle aspiration cytology for the diagnosis of plasma cell neoplasms in the head and neck region: A systematic analysis of the literature

Felix

SENA

Arruda

et al. 2022

Diagnostic Cytopathology

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Background Cytopathologic analysis is feasible and provides detailed morphological characterisation of head and neck lesions. Aims To integrate the available data published on fine‐needle aspiration cytology (FNAC) used for the diagnosis of plasma cell neoplasms (PCN) of the head and neck region. Materials and Methods Searches on PubMed, Web of Science, Embase, and Scopus were performed to compile data from case reports/case series published in English. The Joanna Briggs Institute tool was used for the critical appraisal of studies. Results A total of 82 studies comprising 102 patients were included in this review. There was a predilection for men (68.6%) (male/female ratio: 2.1:1). Individuals in their 50s (29.4%), 60s (22.5%), and 70s (22.5%) were more often affected. The thyroid gland (26.2%) was the main anatomical location, followed by scalp (15.5%), neck/cervical region (15.5%), jaws (13.6%), and major salivary glands (13.6%). For FNAC analysis, a smear was employed in 41 (40.6%) cases and a cell block was used in four (3.9%). In 56 (55.4%) reports, no cytological methods were available. Morphologically, 34 (56.7%) cases had a diagnosis of PCN with agreement between cytopathology and histopathology. The rate of wrong diagnoses when using cytology was 27.5%. Immunophenotyping was performed in 49 (48%) of the cases. The 69‐month disease‐free survival rate was 60.2%, while the 27‐month overall survival rate was 64.1%. Conclusion This study reinforces that FNAC can be an ancillary tool in the first step towards the diagnosis of PCN of the head and neck region, especially when applying a cell block for cytological analysis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fine‐needle aspiration cytology for the diagnosis of plasma cell neoplasms in the head and neck region: A systematic analysis of the literature

Felix

SENA

Arruda

et al. 2022

Diagnostic Cytopathology

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“…17 Ustün et al reported a case of extramedullary plasmacytoma of the parotid gland with extensive amyloid deposition. 18 Majority of these cases had systemic involvement in the form of MMs and isolated plasmacytoma with amyloid deposits have been rarely reported. We have encountered nine cases of localized amyloidosis of the larynx in our experience, of which, only one case has coexisting PCN on histopathology.…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Plasma Cell Neoplasms with Amyloidosis of the Head and Neck Region: A Series of two Rare Cases and Literature Review

Nerurkar¹,

Gala²,

Shah³

et al. 2018

International Journal of Phonosurgery &Amp; Laryngology

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Extramedullary plasmacytomas (EMP) are rare malignant plasma cell neoplasms (PCNs) mainly affecting the head and the neck region. These are more commonly seen in adult males. These have variable outcomes and may even coexist with, or progress to multiple myelomas (MMs). Hence, a systemic examination is a must, to rule out generalized involvement. The presence of monoclonal plasma cells on histopathology explains the relationship of PCNs with amyloidosis. Treatment may be surgical for accessible tumors or low to moderate dose radiation as indicated. Long-term surveillance is a must. We discuss two cases of extramedullary PCNs with amyloidosis involving the head-neck region. Both the patients underwent surgical excision followed by radiation for the residual disease and recurrence prevention. Systemic involvement was ruled out and the patients have been advised regular follow-up.

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“…As mentioned previously, histopathological analysis in isolation is insufficient to confirm a diagnosis of primary extramedullary plasmacytoma, since it is necessary to exclude the possibility of multiple myeloma through skeletal and marrow examinations, immunoelectrophoresis, quantitative immunoglobulin testing, and confirmation of the absence of urinary Bence Jones proteins ( 17 ). Cyclin D1 expression in EOP, as observed in the current patient, has been associated with an unfavourable prognosis in previous studies ( 19 ); however, this did not seem to be true of the present case.…”

Section: Discussionmentioning

confidence: 99%

Primary extraosseous plasmacytoma of the parotid gland: A case report and literature review

González-Pérez

Infante-Cossio

Martín

2017

Molecular and Clinical Oncology

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Extraosseous plasmacytoma (EOP) is an uncommon malignant tumour that is characterised by the monoclonal proliferation of abnormal plasma cells in soft tissue; however, EOP lacks the defining features of multiple myeloma or medullary plasmacytoma. Although the majority of EOP lesions occur in the head and neck, EOP of the parotid gland is extremely uncommon. The present study aimed to explore the clinical features of parotid plasmacytoma, in addition to the diagnostic and therapeutic options for its management. Using the Medline database, a search was conducted for articles published on the topic of ‘parotid plasmacytoma’ up until the year 2016. A total of 20 cases were evaluated, including 19 clinical cases from the literature and 1 new clinical case from our hospital. Among the 19 previously published cases, the mean age at the time of diagnosis of EOP was 65.1±10.9 years (range, 38–78 years). Plasmacytomas were located unilaterally in all cases: On the right side in 9 patients (47.4%), on the left side in 10 patients (52.6%). Treatment included chemotherapy in 3 cases, radiotherapy in 11 cases and surgical removal in 15 cases. The diagnosis of EOP is based on the presence of a localised tumour comprising monoclonal plasma cells, and EOP is identical to multiple myeloma in this regard; however, EOP, in contrast to multiple myeloma, does not exhibit the signs that are indicative of disseminated disease, such as additional lesions on skeletal radiological examination, plasmacytosis in the bone marrow, and hypercalcaemia, anaemia, or renal failure. Thus, EOP must be considered in the differential diagnosis of parotid gland lesions in order to avoid confusion with other tumoural diseases.

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Extramedullary Plasmacytoma of the Parotid Gland

Cited by 15 publications

References 8 publications

Fine‐needle aspiration cytology for the diagnosis of plasma cell neoplasms in the head and neck region: A systematic analysis of the literature

Fine‐needle aspiration cytology for the diagnosis of plasma cell neoplasms in the head and neck region: A systematic analysis of the literature

Extramedullary Plasma Cell Neoplasms with Amyloidosis of the Head and Neck Region: A Series of two Rare Cases and Literature Review

Primary extraosseous plasmacytoma of the parotid gland: A case report and literature review

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