Extramedullary Plasmacytoma of the Head and Neck

Kapadia, Silloo B.; Desai, Uma; Cheng, Vincent S.

doi:10.1097/00005792-198209000-00004

Cited by 181 publications

(142 citation statements)

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“…EMP arising in the head and neck characteristically presents with localized disease, and all but two of the patients reported here had no clinical lymph node involvement. These observations are in agreement with most of the large reported series (Wiltshaw, 1976;Pahor, 1977;Kapadia et al, 1982;Mayr et al, 1990;Shih et al, 1995). …”

Section: Discussion Incidencesupporting

confidence: 93%

“…There may be destruction of adjacent bone in direct continuity with the tumour mass. Poole and Marchetta (1968), Gromer andDuvall (1973), Harwood et al (1981) and Mock et al (1987) felt that the presence of bone destruction seemed to be an unfavourable prognostic factor, while Kotner and Wang (1972), Corwin and Lindberg (1979), Kapadia et al (1982) and Mayr et al (1990) were not of the same opinion. In our series, two of three tumours with bone destruction recurred locally; one of them was a solitary high-grade EMP, and the patient presented with a huge tumour in the paranasal sinuses (Figure 6).…”

Section: Bone Destructionmentioning

confidence: 99%

“…The monoclonal gammopathy disappears following treatment of localized primary tumour. Subsequent development of a paraprotein may signal a recurrence (Kapadia et al, 1982;Mock et al, 1987). Holland et al (1992) felt that patients with paraprotein at the time of diagnosis fared worst, while Harwood et al (1981), Soesan et al (1992) and Shih et al (1995) suggested no effect on prognosis provided they return to normal after treatment.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

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Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Susnerwala

Shanks²,

Banerjee³

et al. 1997

Br J Cancer

184

195

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Summary Extramedullary plasmacytomas (EMP) of head and neck are rare tumours. Between 1972 and 1993, 25 cases of EMP of head and neck were seen at our institute. The clinical and pathological features and response to treatment are presented. At initial presentation, 23 (92%) patients presented with disease confined to a single extramedullary site only and two patients had in addition clinical involvement of cervical lymph nodes. All except these two patients received radiotherapy to the primary site only as initial treatment. Initial primary control of local disease was obtained in 16 of 24 (67%) patients treated with radical intent. With salvage treatment of further radiotherapy and/or chemotherapy, local disease control was achieved in 21 of 24 (88%) patients. One patient was treated with palliative intent. Conversion to multiple myeloma was seen in two patients (8%). Pathologically, the tumours were classified into low, intermediate and high grade, which correlated closely with outcome. This classification has been used for the first time in extramedullary plasmacytomas and is based on the multiple myeloma grading criteria devised by Bartl et al (1987). Fifteen of eighteen (83%) low-grade tumours and only one of six (17%) intermediate-and high-grade tumours were locally controlled after primary radiotherapy. This is statistically significant for local control (P= 0.0019) but not for overall survival (P= 0.12). The median survival and 5-year overall survival is 68 months and 58.9% respectively. We recommend consideration of adjuvant chemotherapy in patients with higher grade disease.

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Section: Discussion Incidencesupporting

confidence: 93%

Section: Bone Destructionmentioning

confidence: 99%

Section: Diagnostic Criteriamentioning

confidence: 99%

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Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Susnerwala

Shanks²,

Banerjee³

et al. 1997

Br J Cancer

184

195

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“…Extramedullary plasmacytomas should be distinguished from non-neoplastic lesions like reactive plasmacytic hyperplasia, plasma cell granuloma, pseudolymphoma and from malignancies like haematopoeitic neoplasms, malignant melanoma, olfactory neuroblastoma, anaplastic carcinoma and metastases. Differentiation between plasmacytoma and polyclonal infiltrates of plasma cells requires immunohistochemical studies [7]. The solitary plasmacytoma can be confirmed after excluding systemic disease by a serum and urine protein electrophoresis, immunoelectrophoresis, a skeletal survey and a marrow biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy is reserved for disseminated disease. Survival depends on dissemination of the disease [7,9]. The prognosis depends on tumour size ([5 cm) and nodal involvement.…”

Section: Discussionmentioning

confidence: 99%

Solitary Extramedullary Plasmacytoma of the Sinonasal Region

Hazarika

Balakrishnan

Singh

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Less than 10% of the patients with plasma cell neoplasms present with a solitary plasmacytoma. Though the nasal cavity is a common extramedullary site, the occurrence is extremely rare. Two cases of solitary extramedullary plasmacytoma of the sinonasal region are reported. The first of which is sinonasal plasmacytoma with concomitant HIV, an association that has been reported rarely in literature to date and is matter of much debate. In the second case report, we present an instance of surgical excision of the tumor using KTP 532 laser. The diagnosis was established using immunohistochemical techniques and multiple myeloma workups were negative in all cases.

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Extramedullary Plasmacytoma of the Thyroid Associated With a Serum Monoclonal Gammopathy

Rubin

Johnson²,

Killeen³

et al. 1990

Archives of Otolaryngology - Head and Neck Surgery

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Extramedullary plasmacytoma is a malignant plasma cell dyscrasia that is most commonly found in the head and neck. Progression to disseminated disease in the form of multiple myeloma occurs in 17% to 32% of cases. Herein, we describe a patient with extramedullary plasmacytoma of the thyroid gland in whom a serum monoclonal gammopathy resolved with surgery and irradiation of the primary. Although rare, this diagnosis should be considered in patients presenting with obstructive thyromegaly and autoimmune thyroiditis.

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Extramedullary Plasmacytoma of the Head and Neck

Cited by 181 publications

References 0 publications

Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Solitary Extramedullary Plasmacytoma of the Sinonasal Region

Extramedullary Plasmacytoma of the Thyroid Associated With a Serum Monoclonal Gammopathy

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