Extramedullary plasmacytoma of oral cavity: Series of three unusual cases at unusual locations

Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India

“…SEP is encountered more frequently in head and neck, in which nasal cavity and nasopharynx are by far the most common sites [6]. According to the literature, SPB is commonly seen in marrow containing bones and SEP is commoner in sites having a rich lymphatic drainage such as upper respiratory tract [6, 8, 13]. In the present study, vertebra was the commonest site for SPB and paranasal sinuses was the commonest site of SEP.…”

“…SPs account for 1–5% of all plasma cell neoplasms [6, 7]. SP may be either solitary plasmacytoma of the bone (SPB), solitary extramedullary (extra-ossesous) plasmacytoma (SEP) or multiple solitary plasmacytomas (MSP) [6, 8]. In SPB, any bone may be involved, but bones that actively produce hematopoietic elements such as pelvis, skull, ribs, spine, femur, clavicle and scapula are more commonly involved [6, 8].…”

“…SP may be either solitary plasmacytoma of the bone (SPB), solitary extramedullary (extra-ossesous) plasmacytoma (SEP) or multiple solitary plasmacytomas (MSP) [6, 8]. In SPB, any bone may be involved, but bones that actively produce hematopoietic elements such as pelvis, skull, ribs, spine, femur, clavicle and scapula are more commonly involved [6, 8]. The plasmacytomas are termed as MSPs when there are multiple sites of involvement in soft tissue, bone or both without any evidence of increased plasma cells on a random iliac crest bone marrow biopsy, associated with absence of hypercalcemia, renal failure or serum monoclonal light chains [9].…”

“…The plasmacytomas are termed as MSPs when there are multiple sites of involvement in soft tissue, bone or both without any evidence of increased plasma cells on a random iliac crest bone marrow biopsy, associated with absence of hypercalcemia, renal failure or serum monoclonal light chains [9]. SEP tend to occur at sites other than bone such as the gastrointestinal tract, the respiratory tract, bladder, thyroid, kidney, pancreas, uterus or the central nervous system [8]. Although, they are histologically similar to MM, albeit are associated with a better prognosis [6].…”

Extramedullary Plasmacytoma Involving the Heart: A Case Report and Focused Literature Review

“…It has been previously reported that negative CD56 is more common in plasma cell leukemia, an aggressive extramedullary plasma cell neoplasm. Several studies reported a reduced CD56 expression in EMPs as compared to MM or solitary plasmacytoma of bone [7][8][9]. It is hypothesized that, as a surface adhesion molecule, CD56 plays a role in the bone marrow localization of tumor cells and its down-regulation may account for its extramedullary localization [10].…”