Extramedullary Plasmacytoma: A Rare Entity

Abstract

Extramedullary plasmacytoma is an immunoproliferative disease of mature B cell that produces immunoglobulins by clonal expansion. Plasma cell neoplasms are responsible for less than 0.1% of all pancreatic masses, they can be primary or secondary to multiple myeloma (MM). We present the case of a 56-year-old man with extramedullary solitary plasmacytoma located in the pancreas, presented with abdominal pain and jaundice. Imaging characteristics are similar to those of other pancreatic diseases, and the diagnosis is confirmed by immunohistochemistry due to the presence of a homogeneous infiltrate of monoclonal plasma cells, which typically express CD38 and CD 138 markers and the presence of kappa/lambda light chains.

Journal of Digestive Endoscopy: Year (2023) in Review

“…A few interesting case reports were published last year in the journal. These included endoscopic submucosal dissection or early gastric cancer in a cirrhotic patient 22 ; peroral endoscopic myotomy in a pediatric patient with idiopathic achalasia 23 ; gastroduodenal intussusception due to gastrointestinal stromal tumor presenting with melena 24 ; a rare case of extramedullary plasmacytoma 25 ; and successful treatment of Plummer Vinson syndrome by use of circumferential endoscopic submucosal dissection. 26…”