Extramedullary nasal plasmacytoma

Abstract

The literature on this rare tumour has been reviewed and three cases of nasal plasmacytoma are described. Immunohistochemistry demonstrated cytoplasmic IgA and Kappa determinants in all cases. Two patients are disease-free at the present time, the third developed an IgG-k multiple myeloma, previously not described in the literature.

Solitary Extramedullary Plasmacytoma of the Sinonasal Region

“…There is a male preponderance of 3:1, mainly in the fifth and sixth decades of life [4]. Patients present mainly with nasal symptoms on the same side of the tumors [5].…”

“…There is a possibility of developing multiple myeloma in 17-33% of these cases [4]. Chemotherapy is reserved for disseminated disease.…”

Plasmocitoma extramedular del tabique nasal: Reporte de un caso y revisión bibliográfica

“…Sin embargo, cuando existe un abundante depósito amiloide dentro de la tumoración, la radioterapia no siempre reducirá el tamaño del tumor [21][22][23] . Ésta es la razón por la que la mayoría de los clínicos recomiendan un tratamiento combinado que incluya cirugía más radioterapia en el manejo del PEM de la cavidad nasal 23,24 . Existe la evidencia en los estudios de Alexiou y cols mostrando que esta combinación da mejores resultados.…”

Letters to the Editors

“…4 FNA cytology has been used in recent years in the diagnosis of angiosarcoma of the skin, breast, liver, heart, soft tissues and bone. 2,7,8,10,12 Only one previous report has been published on the cytologic findings of poorly differentiated angiosarcoma of bone that also presented as a lytic lesion. 2 While criteria for the histologic diagnosis of an- …”

“…9,11 Most authors have observed spindle or oval tumor cells, often with hyperchromatic nuclei and significant pleomorphism. 7,8,10,12,13 In addition to the spindle cell population, other cell types have been described in some reports, including large, round to oval cells. 8,10 This last cell type was the predominant one observed in the present case.…”