Extramedullary Hematopoiesis in Patients with Thalassemia Anemia

Korsten, J.; Grossman, Herman; Winchester, Patricia; Canale, Virginia C.

doi:10.1148/95.2.257

Cited by 30 publications

(11 citation statements)

References 13 publications

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“…Expansile lesions of the ribs due to marrow proliferation may also be found in patients with thalassemia or in those with myelofibrosis, but only rarely will they be solitary. [4][5][6] The radiologic findings on the rib lesion in our patient share certain similarities with the two previously described cases. All lesions were described as expansile, relatively radiolucent and containing linear or trabeculated areas that, after histologic examination, performed in the previous two cases, were …”

Section: Discussionsupporting

confidence: 80%

Focal Hematopoietic Hyperplasia of the Rib

et al. 1998

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Section: Discussionsupporting

confidence: 80%

Focal Hematopoietic Hyperplasia of the Rib

et al. 1998

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“…It occurs most commonly in untransfused patients with thalassemia intermedia and less commonly in inadequately transfused β-TM patients when erythropoiesis is not suppressed adequately by transfusions. 9 The incidence of EMH in patients with thalassemia intermedia may reach up to 20% compared to TM patients where the incidence is less than 1%. 1 The most common site involved by EMH in thalassemia patients is spinal column particularly thoracic region.…”

Section: Discussionmentioning

confidence: 99%

Adrenal Extramedullary Hematopoiesis Associated with β-Thalassemia Major

2012

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The presence of apparently normal hematopoietic tissue outside of bone marrow cavity is defined as extramedullary hematopoiesis (EMH). EMH is a rare complication in thalassemia major (TM) and adrenal gland as well. This report describes a case of adrenal EMH in a 26-year-old man with β-TM. He has been transfused with regular blood transfusion since 9 months. During the routine physical examination he was incidentally found to have a hypoechoic mass at his abdominal ultrasonography. Abdominal computed tomography scan revealed a right well-defined suprarenal mass 7.7×7.3×5.8 cm in size. The diagnosis of EMH was confirmed with ultrasonographic-guided fine needle biopsy. Treatment options which include intensified regular blood transfusion and hydroxyurea have been started.

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“…3 It presents usually in patients with thalassemia and severe anemia, but it has been described also in patients with leukemia, hemoglobinopathies, and myelofibrosis. Usual sites for presentation include liver, spleen, adrenals, heart, thymus, lungs, lymph nodes, kidneys, and gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%