Extramedullary Hematopoiesis: Breathtaking and Hair-Raising

Fh, Krouwels; Bresser, Paul; Borne, von dem

doi:10.1056/nejm199911253412219

Cited by 14 publications

(10 citation statements)

References 5 publications

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“…[3] Another suggests that extramedullary sites are due to “seeding” from circulatory pluripotent hematopoietic cells. [4] Extramedullary hematopoiesis should be in the differential diagnosis of any chronic hemolytic patient with a mediastinal mass. [5] A close association between this entity and thalassemia has been described.…”

Section: Discussionmentioning

confidence: 99%

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Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

2007

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Extramedullary hematopoiesis is a rare cause of an intrathoracic mass in individuals with hemolytic disorders. It can be clinically confused with other tumors of the mediastinum. While radiologic studies often demonstrate findings suggesting intrathoracic extramedullary hematopoiesis, histology is usually required for diagnostic purposes. Thoracotomy was the mainstay procedure for obtaining tissue diagnosis and resection. However, video-assisted thoracoscopy (VATS) is an amendable and less-invasive means of tumor removal. We report a case of a posterior mediastinal extramedullary hematopoietic mass in a forty-two year old male in which VATS was utilized for diagnosis and resection.

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Section: Discussionmentioning

confidence: 99%

“…[1] They can present as unilateral, bilateral or as multiple masses in the paravertebral area, anterior mediastinum, pericardium and pleura. [34]…”

Section: Discussionmentioning

confidence: 99%

Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

2007

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“…Szintigraphische Verfahren inkl. der Single-Photon-EmissionsComputertomographie (SPECT) sind nur als ergänzende diagnostische Maß-nahmen zu betrachten [11,24,27].…”

Section: Extramedullary Hematopoiesis In the Paravertebral Spaceunclassified

“…Neben differentialtherapeutischen Maßnahmen wie der Hypertransfusion von Erythrozytenkonzentraten bei der Thalassaemia major [1,24,27], Gabe von Zytostatika bei myeloproliferativen Syndromen [27] oder neurochirurgischen Maßnahmen wie der Laminektomie in neurologischen Notfallsituationen [19,22] gilt die Radiotherapie dieser sehr strahlensensiblen Raumforderungen als Therapieverfahren der ersten Wahl [7,[18][19][20]27]. Die optimale Strahlendosis ist dabei nicht bekannt [19,24,31].…”

Section: Extramedullary Hematopoiesis In the Paravertebral Spaceunclassified

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Extramedulläre Blutbildung im paravertebralen Raum

Raab¹,

Simon²,

Schmidtberger³

et al. 2002

Medizinische Klinik

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Clinical presentation, knowledge of the underlying disease and of imaging findings are essential in the diagnosis of extramedullary hematopoiesis. MRI is the imaging modality of choice in the primary diagnosis of extramedullary hematopoiesis. Possible extension of the disease into the intraspinal space can be evaluated with high accuracy and differential diagnosis can be facilitated. In addition, MRI is of use in the accurate planning of radiation fields as well as during follow-up of extramedullary hematopoiesis.

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Pleural mass forming extramedullary hematopoiesis masquerading as a malignant neoplasm

Meykler

Obstfeld

Jhala

et al. 2015

Diagnostic Cytopathology

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Extramedullary hematopoiesis (EMH) represents the presence of immature hematopoietic elements and their differentiation into mature blood components outside of the medullary bone and may be seen in a variety of circumstances in the postnatal period, but is most strongly associated with disorders of the hematopoietic system. Postnatally, EMH is typically identified at sites of fetal hematopoiesis, the spleen, and liver, but occasional reports have identified it in nearly every tissue of the body. We report a case of EMH presenting as pleural mass, initially suspected to represent a neoplastic process in a patient with multiple comorbidities, including history of carcinoma, but without co-existing hematologic disorder. On-site evaluation of the fine-needle aspiration specimen was initially suspicious for a malignant neoplasm, but further evaluation revealed the lesion to be a mass forming focus of non-hepatosplenic EMH. In the era of increasing utilization of imaging, mass forming EMH is increasingly detected. When unsuspected, EMH may present a diagnostic challenge for the pathologist and may be confused for a neoplastic process.

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Extramedullary Hematopoiesis: Breathtaking and Hair-Raising

Cited by 14 publications

References 5 publications

Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

Extramedulläre Blutbildung im paravertebralen Raum

Pleural mass forming extramedullary hematopoiesis masquerading as a malignant neoplasm

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