Extramedullar plasmacytoma: clinicopathology, immunohistochemistry and therapeutic approach to a case with a tonsillar site

Tokatli, Füsun; Puyan, Fulya Öz; Alas, Ruşen Çoşar; Tunçbilek, Nermin; Uzal, Cem

doi:10.1016/s1658-3876(08)50012-4

Cited by 4 publications

(9 citation statements)

References 18 publications

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“…Imaging examination involves radiologic skeletal survey, magnetic resonance imaging of spine, pelvis, humerus and femurs. Treatment of such neoplasm includes radiotherapy following surgery [8,15].…”

Section: Discussionmentioning

confidence: 99%

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Tonsillar Non-secreting Plasmacytoma in a Woman

Kouroupi¹,

Sivridis²,

Arelaki³

et al. 2018

JCR

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Background: Plasmacytomas are characterized by excessive proliferation of neoplastic plasma cells in the bone marrow. Extra-medullary plasmacytoma are by and large, encountered in the head and neck region and only rarely occur in the tonsils. Case Report: We report here a asymptomatic solitary non-secreting plasmacytoma of the right tonsil in a middle-aged woman. The diagnosis of a plasmacytoma was reached after surgical excision. Conclusion: Tonsil is a rare sight of plasmacytoma origin with no specific symptoms, thus recommendation of WHO 2015 for such tumors must be taken under consideration.

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Section: Discussionmentioning

confidence: 99%

“…Extramedullary plasmacytomas usually occur in the head and neck region (80%) [2,3], with the nasopharynx and sinonasal cavities being the most common sites [4][5][6]. Involvement of the tonsil is unusual [7,8] with only a few cases having been reported. Incidence is more in men (75%) [9].…”

Section: Introductionmentioning

confidence: 99%

Tonsillar Non-secreting Plasmacytoma in a Woman

Kouroupi¹,

Sivridis²,

Arelaki³

et al. 2018

JCR

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“…EMP is a plasma cell neoplasm that occurs predominantly in the upper aerodigestive tract [4]. Most lesions of the head and neck occur in the sinonasal region [1].…”

Section: Discussionmentioning

confidence: 99%

“…While inhalant exposure has been proposed as a risk factor for EMP of the head and neck, evidence to support this has been inconclusive [4]. Patients with EMP of the tonsil present with symptoms referable to unilateral tonsil enlargement including obstructed breathing.…”

Section: Discussionmentioning

confidence: 99%

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Extramedullary Plasmacytoma of the Tonsil

Huoh

Zante

Eisele

2011

Case Reports in Otolaryngology

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Plasma cell tumors are a diverse group of neoplasms characterized by monoclonal proliferation of plasma cells. Extramedullary plasmacytoma (EMP) is a rare form of localized plasma cell tumor that arises most often in the head and neck region. We present an unusual case of EMP of the palatine tonsil from a tertiary care university hospital. We discuss the histopathologic and radiologic evaluation as well as treatment of EMP.

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Tonsillar Plasmacytoma: clues on magnetic resonance imaging

2018

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BackgroundMalignant plasma cell proliferation may present as a disseminated disease (multiple myeloma), a solitary plasmacytoma of bone, or an extramedullary plasmacytoma of soft tissue. The latter plasmacytomas represent approximately 3% of all plasma cell proliferations, and 80% develop in the head-and-neck region. The unexpected clinical presentation of such masses may be present.Case presentationHere, we report a rare case of primary tonsillar plasmacytoma in a 42-year-old female. The patient presented with asymmetric tonsillar hypertrophy that was resistant to antibiotherapy. Upon further workup, we found no evidence of multiple myeloma or light-chain disease. The patient underwent surgery and, at the last follow-up, exhibited no evidence of such disease.ConclusionsIn adults presenting with asymptomatic tonsillar enlargement, the possibility of submucosal masses should be considered, thus encouraging the radiologist to evaluate crypts within the palatine tonsil on a postcontrast MRI, besides enlargement and signal change.

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Extramedullar plasmacytoma: clinicopathology, immunohistochemistry and therapeutic approach to a case with a tonsillar site

Cited by 4 publications

References 18 publications

Tonsillar Non-secreting Plasmacytoma in a Woman

Tonsillar Non-secreting Plasmacytoma in a Woman

Extramedullary Plasmacytoma of the Tonsil

Tonsillar Plasmacytoma: clues on magnetic resonance imaging

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