Extramammary Paget’s Disease of the Floor of Mouth Associated With Minor Salivary Gland Carcinoma and Concurrent Invasive Squamous Cell Carcinoma

Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review

“…There was an underlying poorly differentiated carcinoma with rare mucin production and a hyaline matrix, that metastasized to cervical lymph nodes and lung. A third case involved the floor of the mouth and was associated with salivary gland carcinoma and concurrent invasive squamous cell carcinoma, complicated by lymph node metastasis 19 . A fourth case was reported in association with submandibular gland salivary duct carcinoma and multiple lung metastases 20 .…”

“…The reported phenotype of two cases of primary oral EMPD was CK7 + and CK20 − , with a third case of CK7 + with unknown CK20 8–10 . Conversely, a case of secondary oral EMPD was CK7 + 19 . As many salivary gland tumors are CK7 + , the utility of CK7 and CK20 immunohistochemistry in predicting underlying internal malignancy remains uncertain 29,30 .…”

“…A third case involved the floor of the mouth and was associated with salivary gland carcinoma and concurrent invasive squamous cell carcinoma, complicated by lymph node metastasis. 19 A fourth case was reported in association with submandibular gland salivary duct carcinoma and multiple lung metastases. 20 Finally, a case of perioral EMPD associated with oral adenocarcinoma was recently reported, although neither immunohistochemical results, oral mucosal involvement, nor the histologic type of underlying adenocarcinoma was reported.…”

“…8-10 Conversely, a case of secondary oral EMPD was CK7 + . 19 As many salivary gland tumors are CK7 + , the utility of CK7 and CK20 immunohistochemistry in predicting underlying internal malignancy remains uncertain. 29,30 The current case was CK7 + and CK20 + , an immunophenotype associated with urothelial carcinoma and colorectal carcinoma, among others.…”

Extramammary Paget's disease of the oral tissues—literature review and a rare case report

“…EMPD of the oral tissues, an extremely rare condition, was first reported by Changus et al [ 5 ] in 1971. To our knowledge, there are just three globally published cases of EMPD of the oral tissues [ 5 – 7 ].…”