Extramammary Paget Disease of Scrotum With Oncocytic Changes

Aneiros‐Fernández, José; Arias‐Santiago, Salvador; Husein‐ElAhmed, Husein; Nicolae, Alina; Ravassa, F OʼValle; Serrano‐Ortega, S.; Fernández, Francisco Nogales; Cachaza, José Aneiros

doi:10.1097/dad.0b013e3181d29de3

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“…16,21 A single case of EMPD with oncocytic changes has been described. 34 The syringomalike structures reported here extend the morphological spectrum …”

Section: Discussionmentioning

confidence: 90%

Syringomatous Structures in Extramammary Paget Disease: A Potential Diagnostic Pitfall

Konstantinova

Hayes

Stewart

et al. 2016

The American Journal of Dermatopathology

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Primary extramammary Paget disease (EMPD) is a form of intraepithelial adenocarcinoma. Different morphological changes may accompany EMPD, including the presence of syringoma-like structures. The authors report 10 cases of EMPD, all of which manifested syringoma-like structures within the dermis both in areas involved by the carcinoma and beyond, including at the margins of the excisions. All patients were women, whose ages ranged from 49 to 93 years (median 75 years). The possible pathogenesis of the syringoma-like lesions is discussed. Awareness of these structures in vulvectomy specimens for EMPD is important to prevent misinterpretation of the syringoma-like lesions as an invasive component of the EMPD.

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“…16,21 A single case of EMPD with oncocytic changes has been described. 34 The syringomalike structures reported here extend the morphological spectrum …”

Section: Discussionmentioning

confidence: 90%