Extralobar pulmonary sequestration with elevated serum neuron-specific enolase

Abstract

Rationale: Pulmonary sequestration (PS) presenting with elevated serum tumor markers is rare, and it might be misdiagnosed as malignancy. Patient concerns: A 26-year-old asymptomatic male patient was admitted because the x-ray showed an intrathoracic lesion. Meanwhile, the serum neuron-specific enolase (NSE) was elevated. Three-dimensional computed tomography angiography revealed an isolated feeding vessel arising from the aorta. Diagnoses: Extralobular PS was confirmed by computed tomography angiography and postoperative pathological staining. Interventions: Two-port thoracoscopic resection of the sequestrated lobe was performed. Outcomes: The serum NSE decreased to within the normal range and persisted during the follow up of 10 months. Lessons: A thorough work-up should be considered for the PS patients presenting with abnormal serum NSE. Detailed knowledge regarding the relationship between NSE and PS necessitates further studies.

Advances and Challenges in Nanomaterial-Based Electrochemical Immunosensors for Small Cell Lung Cancer Biomarker Neuron-Specific Enolase

“…It is a specific marker for neurons and peripheral neuroendocrine cells and so the most reliable tumor marker in the diagnosis, prognosis, and post-treatment of small-cell lung cancer. NSE being a human brain protein is present in about 0.4–2.2% (>5 ng mL –1 ) of total soluble protein of the brain, and excessive increase in such levels indicates a metastatic disease such as melanoma, seminoma, renal cell carcinoma, carcinoid tumors, Guillain-Barre syndrome, Creutzfeldt-Jakob disease, and so on. , The amount of NSE present in the brain predicts quantifiable measures of brain damage, which lead to strokes, hemorrhage, seizures, etc . Recently, reports have published sufficient data of COVID-19 positive patients showing the elevated level of NSE, signifying the role of NSE as a potential clinical biomarker for COVID-19 because it primarily targets human respiratory and neurological systems. , …”

“…Reprinted with permission from Biosens. Bioelectron 2019, 143, 111612, Copyright, 2017, Elsevier 23.…”