Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis

Wongchaisuwat, Nida; Khongpipatchaisiri, Sansanee; Boonsopon, Sutasinee; Choopong, Pitipol; Tesavibul, Nattaporn; Prakhunhungsit, Supalert; Thoongsuwan, Somanus; Rodanant, Nuttawut; Phasukkijwatana, Nopasak

doi:10.1038/s41598-020-78587-6

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Wongchaisuwat studied macular vascular changes in eyes with CMVR without macular involvement. Their results showed decreased VD in both the superficial and deep retinal capillary plexus ( 22 ). We also showed decreased superficial and inner retinal VD in certain quadrants.…”

Section: Discussionmentioning

confidence: 99%

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Macular Structure and Microvasculature Changes in AIDS-Related Cytomegalovirus Retinitis Using Optical Coherence Tomography Angiography

Huang

Chen

et al. 2021

Front. Med.

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Background: Cytomegalovirus retinitis (CMVR) is a crucial blind-causing disease of AIDS-related ocular opportunistic infection. The CMVR lesions produced retinal necrosis. It is not entirely clear whether CMVR eyes without macular-involved necrotic lesions may have subtle macular damage. In this study, we conducted a cross-sectional study using optical coherence tomography angiography (OCTA) to evaluate macular microvasculature and structure in eyes with AIDS-related CMVR.Methods: Acquired immune deficiency syndrome (AIDS)-related CMVR patients (active and inactive CMVR) and healthy controls treated in the Department of Ophthalmology, Beijing Youan Hospital, Capital Medical University between August 25, 2019, and October 18, 2019, were recruited. All OCTA parameters, including the foveal avascular zone (FAZ), retinal vessel density (VD), choroidal vascularity index (CVI), retinal thickness, and choroidal thickness, were compared between groups after the signal strength was corrected.Results: Signal strength in the 3 × 3 and 6 × 6 mm scan patterns was significantly weaker in the inactive CMVR group than in the control group (both p < 0.001). After adjusting for signal strength, heterogeneity in the central fovea and parafoveal quadrants was present with a shift toward lower macular chorioretinal vasculature, decreased full choroidal thickness, and thicker retinal thickness in the active and inactive CMVR groups. The retinal nerve fiber layer (RNFL) and inner nuclear layer (INL) were significantly thicker in the active and inactive CMVR groups than in the control group (all p < 0.05). For photoreceptor-retinal pigment epithelium (PR-RPE) thickness, no significant differences were found in any quadrant between groups. Foveal avascular zone areas were not significantly different among the three groups (p = 0.053).Conclusions: Subtle macular structure and microvasculature damage still existed in CMVR eyes without macular-involved necrotic lesions. The results of our study are helpful for a deep understanding of the damage caused by CMVR.

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Section: Discussionmentioning

confidence: 99%

“…Optical coherence tomography angiography signal strength is a quality-image measure. Previous studies described only the cut-off value of the signal strength index ( 23 ), qualitative judgement for signal detection ( 6 ), or degree of vitreous haze ( 22 ). We showed a quantitative judgement of the signal strength.…”

Section: Discussionmentioning

confidence: 99%

Macular Structure and Microvasculature Changes in AIDS-Related Cytomegalovirus Retinitis Using Optical Coherence Tomography Angiography

Huang

Chen

et al. 2021

Front. Med.

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Multimodal Imaging in Infectious Uveitis

Nicola¹,

Bhat²,

Lobo-Chan³

2023

Advances in Ophthalmology and Optometry

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Choriocapillaris Loss in a Pediatric Patient With Congenital Cytomegalovirus Seen on Optical Coherence Tomography Angiography

Kozek,

Morcos,

Hoyek

et al. 2024

Journal of VitreoRetinal Diseases

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Purpose: To describe choriocapillaris loss on optical coherence tomography angiography (OCTA) imaging in a pediatric patient with congenital cytomegalovirus (CMV). Methods: A case was evaluated. Results: A 7-year-old female patient was referred for retinal evaluation of maculopathy in the right eye. She was diagnosed with congenital CMV at 14 months of age, at which time treatment was not deemed necessary. At 7 years of age, the patient was asymptomatic with 20/20 Snellen visual acuity. Funduscopy and colored fundus photographs showed macular scarring. Ancillary testing was performed, with retinal pigment epithelium alterations and disruption of the outer retinal layers seen on OCT and choriocapillaris loss in the area of the macular scar seen on OCTA. Conclusions: For patients with congenital CMV, OCTA imaging can show significant changes in choriocapillaris function. These changes do not necessarily correlate with visual function parameters. OCTA may be useful as an additional screening or surveillance modality for patients with congenital CMV or CMV retinitis.

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Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis

Cited by 4 publications

References 26 publications

Macular Structure and Microvasculature Changes in AIDS-Related Cytomegalovirus Retinitis Using Optical Coherence Tomography Angiography

Macular Structure and Microvasculature Changes in AIDS-Related Cytomegalovirus Retinitis Using Optical Coherence Tomography Angiography

Multimodal Imaging in Infectious Uveitis

Choriocapillaris Loss in a Pediatric Patient With Congenital Cytomegalovirus Seen on Optical Coherence Tomography Angiography

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