Extraintestinal Manifestations of Inflammatory Bowel Disease: Epidemiology, Etiopathogenesis, and Management

Garber, Ari; Regueiro, Miguel

doi:10.1007/s11894-019-0698-1

Cited by 67 publications

(66 citation statements)

References 133 publications

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“…The body sites that patients with UC reported pain in was more often located in the lower half of the body, from the lower back to the foot region, in comparison to pain reported by control persons. This is consistent with the known association between SpA and UC [4]. In the present study, the overall prevalence of lower back pain in patients with UC was 30% compared to 23% in the control group.…”

Section: Discussionsupporting

confidence: 93%

“…Several studies have reported a high prevalence of extraintestinal symptoms including MSK pain in patients with UC [4,6] but to our knowledge, this is the first study that compare reported chronic pain in patients with a diagnosis of UC and persons from a general population. This present study shows that the prevalence of chronic pain, both ChWP and ChRP, was significantly higher among patients with UC compared to controls.…”

Section: Discussionmentioning

confidence: 86%

“…The incidence of IBD is rising globally and the estimated prevalence in the western countries is approximately 0.3% [2]. There is an overlap between IBD and other chronic inflammatory conditions [3] and patients with IBD commonly exhibit extra-intestinal symptoms [4]. Peripheral arthritis is the most common extra-intestinal symptom reported with a prevalence of 21-33% [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study

Pettersson

Kragsbjerg

Hamrin

et al. 2020

Scandinavian Journal of Gastroenterology

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Backgrounds/aims: Musculoskeletal symptoms are common in patients with ulcerative colitis (UC), but no study has compared the prevalence of chronic pain to controls from a general population. Methods: Patients with UC (n ¼ 1164) and controls (n ¼ 3867) were sent questionnaires comprising demography, history of pain, pain localization and UC patients' Patient-Simple Clinical Colitis Activity Index. Chronic regional pain (ChRP) and chronic widespread pain (ChWP) were defined as having pain for at least 3 months. Results: The response rate for the patients with UC was 49.0% and for the control persons 61.7% (p < .001). The reported prevalence of ChRP and ChWP was higher in patients with UC versus controls (33.1% vs. 24.2%; p < .001 and 19.8% vs. 12.5%; p < .001). The patients with UC reported significantly more pain in the regions 'lower back', 'hip/upper leg' and 'lower leg/foot' compared to controls. The patients with P-SCCAI 5 (n ¼ 121) reported more ChWP than patients with P-SCCAI <5 (n ¼ 426) (46.3% vs. 12.7%; p < .001) and controls (n ¼ 2425) (46.3 vs. 12.5%; p < .001) in all body regions. No significant difference in ChWP was found between patients with P-SCCAI <5 and controls (12.7% vs. 12.5%; p ¼ .917). Conclusions: Patients with UC reported more chronic pain than controls from the general population, especially from the lower back and hip region. Higher UC disease activity was associated with more pain in all body regions.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study

Pettersson

Kragsbjerg

Hamrin

et al. 2020

Scandinavian Journal of Gastroenterology

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“…However, IBD also displays certain extraintestinal manifestations. For instance, studies have reported an association between IBD and arthritis ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Inflammatory Bowel Disease Among Patients With Ankylosing Spondylitis: A 13-Year Population-Based Cohort Study

et al. 2020

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Aim Ankylosing spondylitis (AS) primarily affects the axial skeleton and extraarticular structures. Small-scaled studies have reported that the incidence and prevalence of inﬂammatory bowel disease (IBD) are higher in patients with AS than in the general population. This study determined the incidence of IBD in patients with AS using a large scale population-based cohort dataset. Methods This was a retrospective cohort study. Patient data were collected from the Taiwan National Health Insurance Research Database from 2000 to 2012. We enrolled 3,804 patients with AS and 7,608 non-AS patients. The endpoint was IBD diagnosis by using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) coding 555 and 556 after at least three outpatient visits or one hospital admission, until the end of 2012. The Kaplan–Meier analysis was performed to discriminate the cumulative incidence of IBD and the log-rank test was used to test the significance. A Cox proportional hazard model was used to estimate the hazard ratio (HR) for IBD between the AS and non-AS groups. Results Among the population as a whole the Cox proportional hazard regression indicated that patients aged ≥65 years [adjusted HR (aHR): 2.48, 95% confidence interval (CI): 1.38–4.47] or with comorbidity of cancer (aHR: 3.51, 95% CI: 1.40–8.80) had a higher HR for IBD. Kaplan–Meier curves of cumulative incidence proportion of IBD indicated that patients with AS had a higher risk of IBD than the non-AS group in the subgroup aged <40 years (HR: 2.85, 95% CI: 1.51–5.40, p = 0.001). Conclusions Patients with AS aged <40 years had a higher IBD risk than did those without AS in Taiwan. Clinicians and patients should be aware of this association.

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“…1,2 While the disease is predominantly described as a gastrointestinal disease, symptoms involving other organ systems are increasingly recognized. 3,4 In the past decade, studies conducted in both animals and human models have suggested that several genetic factors are involved in the pathogenesis of IBD. [5][6][7][8][9][10] Animal studies have argued for an immune mediated role for IBD.…”

Section: Plain Language Summarymentioning

confidence: 99%

<p>Identification of Novel Therapeutic Molecular Targets in Inflammatory Bowel Disease by Using Genetic Databases</p>

Mohan

Mok²,

Judge

2020

CEG

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Purpose: Utilization of genetic databases to identify genes involved in ulcerative colitis (UC), Crohn's disease (CD), and their extra-intestinal manifestations. Methods: Protein coding genes involved in ulcerative colitis (3783 genes), Crohn's disease (3980 genes), uveitis (1043 genes), arthritis (5583 genes), primary sclerosing cholangitis (PSC) (1313 genes), and pyoderma gangrenosum (119 genes) were categorized using four genetic databases. These include Genecards: The Human Gene Database (www.genecards.

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Extraintestinal Manifestations of Inflammatory Bowel Disease: Epidemiology, Etiopathogenesis, and Management

Cited by 67 publications

References 133 publications

Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study

Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study

Increased Risk of Inflammatory Bowel Disease Among Patients With Ankylosing Spondylitis: A 13-Year Population-Based Cohort Study

<p>Identification of Novel Therapeutic Molecular Targets in Inflammatory Bowel Disease by Using Genetic Databases</p>

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