Extraintestinal manifestations and complications in IBD

Ott, Claudia; Schölmerich, Jürgen

doi:10.1038/nrgastro.2013.117

Cited by 290 publications

(272 citation statements)

References 114 publications

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“…Multiple other organ systems can be affected in IBD patients, including bones and joints, skin and eyes [22,23]. In our case series, 8 of 13 (62%) patients had extraintestinal manifestations; all had IBD-associated arthritis/arthropathy.…”

Section: Discussionmentioning

confidence: 94%

Induction or Exacerbation of Psoriasis in Patients with Crohn's Disease under Treatment with Anti-TNF Antibodies

Barthel

Biedermann²,

Frei³

et al. 2014

Digestion

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Background and Aims: Paradoxically, psoriasis or psoriasiform skin lesions induced or exacerbated by anti-TNF antibodies have been described. Here, we report a series of 13 novel cases featuring exacerbation or occurrence of psoriatic skin lesions induced by anti-TNF antibodies in patients with Crohn's disease (CD). Methods: We performed a systematic analysis of exacerbation or occurrence of psoriasis or psoriasiform skin lesions induced by anti-TNF antibodies in an inflammatory bowel disease patient cohort at the University Hospital Zurich. Results: We identified 13 CD patients who developed psoriasis or psoriasiform lesions while receiving anti-TNF therapy. 10 of the 13 patients were female with an average age of 26.9 years at diagnosis. 11 of the 13 patients had a complicated disease. The mean time of clinical latency between diagnosis and onset of psoriasis was about 9.4 years, and the time between the beginning of all biological infusions and the onset of psoriasis was about 7 months. 7 of the 13 patients received infliximab, 3 adalimumab, and 3 certolizumab pegol at onset of psoriasis. In most of the cases, anti-TNF therapy was changed or discontinued and skin lesions improved. Conclusion: Most of our described patients featured a complicated disease course of CD and had an improvement of the rash after changing the anti-TNF therapy.

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Section: Discussionmentioning

confidence: 94%

Induction or Exacerbation of Psoriasis in Patients with Crohn's Disease under Treatment with Anti-TNF Antibodies

Barthel

Biedermann²,

Frei³

et al. 2014

Digestion

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“…Previous studies have reported that as many as 30% of patients with IBD have at least one extraintestinal manifestation, such as pyoderma gangrenosum (PG), erythema nodosum, polyarthritis, or iritis (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Pyoderma Gangrenosum with Ulcerative Colitis Successfully Treated by the Combination of Granulocyte and Monocyte Adsorption Apheresis and Corticosteroids

Ohno¹,

Koyama²,

Ohara³

et al. 2016

Intern. Med.

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A 36-year-old woman was admitted to our hospital due to swelling and redness of the left lateral malleolus and dorsum of the left foot with severe pain, with a flare-up of ulcerative colitis (UC). A pathologic examination by skin biopsy led to a diagnosis of pyoderma gangrenosum (PG). She was treated with the intravenous administration of prednisolone (60 mg/day), and granulocyte and monocyte adsorption apheresis (GMA) was performed twice-a-week for 5 weeks. This treatment dramatically improved both the skin and colonic mucosal lesions. These results suggest that a combination of GMA and corticosteroids might be recommendable to induce the remission of serious PG complicated with UC.

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“…Bone loss is considered to be a disabling complication of inflammatory bowel disease (IBD) (1). Bone mineral density (BMD) testing results of patients with IBD from seven medical facilities, ranging from January 1996 to October 2006, were reviewed to determine the prevalence rate of osteoporosis (2).…”

Section: Introductionmentioning

confidence: 99%

Osteoporosis as an initial manifestation in a patient with Crohn's disease: A case report

et al. 2018

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Extraintestinal manifestations and complications in IBD

Cited by 290 publications

References 114 publications

Induction or Exacerbation of Psoriasis in Patients with Crohn's Disease under Treatment with Anti-TNF Antibodies

Induction or Exacerbation of Psoriasis in Patients with Crohn's Disease under Treatment with Anti-TNF Antibodies

Pyoderma Gangrenosum with Ulcerative Colitis Successfully Treated by the Combination of Granulocyte and Monocyte Adsorption Apheresis and Corticosteroids

Osteoporosis as an initial manifestation in a patient with Crohn's disease: A case report

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