Extrahepatic metastasectomy for hepatocellular carcinoma: Predictors of long‐term survival

Berger, Yaniv; Spivack, John; Heskel, Marina; Aycart, Samantha N.; Labow, Daniel M.; Sarpel, Umut

doi:10.1002/jso.24555

Cited by 15 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously mentioned, the prognosis of HCC patients with LN metastasis is improving, and some studies have shown that stage IV HCC patients demonstrated a different prognosis [16][17][18] .Therefore, it is important to distinguish the difference in prognosis in such patients. and provide a basis for follow-up treatment.…”

Section: The Establishment Of Different Risk Groups According To the mentioning

confidence: 97%

“…It is undeniable that lymph node metastasis is a poor prognostic factor for hepatocellular carcinoma [9,15] . However, with the development of various treatments and drugs in recent years, the prognosis of HCC patients with lymph node metastases has been improving [16][17][18] . Previous studies have shown that patients who were diagnosed with stage IV HCC demonstrated a different prognosis [18] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A practical nomogram from the SEER database to predict the prognosis of hepatocellular carcinoma patients with lymph node metastasis

Zhang

Tao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The presence of lymph node metastases is related to poor survival outcomes in hepatocellular carcinoma patients and because of the reported low probability of lymph node metastasis, research into the prognoses of such patients is difficult to conduct. In this study, we aimed to develop a nomogram model to predict the prognosis of HCC patients with lymph node metastasis and provided a reasonable basis for the choice of follow-up treatment.Methods: HCC patients diagnosed with LN metastasis from 2010 to 2015 were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate Cox regression and lasso regression were used to screen prognostic factors. Cox multiple-factor analysis was employed to investigate the independent prognostic factors for survival. The concordance index (C-index) and calibration curve were used to evaluate the predictive performance of our model. The clinical benefit was assessed via decision curve analysis (DCA). The survival was analyzed using Kaplan-Meier method and the differences among survival curves were compared by the log-rank test.Results: Patients were randomized into the training group (944 patients) and the validation group (402 patients) in a 70:30 ratio. Grade, T stage, surgery to the liver, chemotherapy, radiation recode, AFP, fibrosis score, tumor size group, M stage were selected as independent prognostic factors, and we developed nomograms using these variables. The c-indices of the training and validation groups were 0.70 and 0.73, respectively. The calibration curves for probability of survival showed good agreement. The DCA indicated that the nomogram had positive net benefits. Patients were divided into two risk groups according to our model, survival curves were drawn, and the log-rank test was performed, the p-value of which was <0.001.Conclusions: The nomogram can accurately predict the prognosis of HCC patients with lymph nodes metastasis and provide a reasonable basis for treatment.

show abstract

Section: The Establishment Of Different Risk Groups According To the mentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

A practical nomogram from the SEER database to predict the prognosis of hepatocellular carcinoma patients with lymph node metastasis

Zhang

Tao

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…As previously mentioned, the prognosis of HCC patients with LN metastasis is improving, and some studies have shown that stage IV HCC patients demonstrated a different prognosis [14][15][16] . Therefore, it is important to distinguish the difference in prognosis in such patients.…”

Section: Discussionmentioning

confidence: 92%

“…It is undeniable that lymph node metastasis is a poor prognostic factor for hepatocellular carcinoma [9] . However, with the development of various treatments and drugs in recent years, the prognosis of HCC patients with lymph node metastases has been improving [14][15][16] . Previous studies have shown that patients who were diagnosed with stage IV demonstrated a different prognosis, indicating that hereditary factors could contribute to the prognosis of such patients [16] .…”

Section: Introductionmentioning

confidence: 99%

“…However, with the development of various treatments and drugs in recent years, the prognosis of HCC patients with lymph node metastases has been improving [14][15][16] . Previous studies have shown that patients who were diagnosed with stage IV demonstrated a different prognosis, indicating that hereditary factors could contribute to the prognosis of such patients [16] . The prognosis of HCC patients with lymph node metastases is different, although they were treated with similar external beam radiotherapy in a study [17] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A practical nomogram predicting the prognosis of hepatocellular carcinoma patients with lymph node metastasis: A population-based analysis

Zhang

Tao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Lymph node (LN) metastasis is associated with poor survival outcomes in patients with hepatocellular carcinoma (HCC) patients and because of the reported low probability of lymph node metastasis, research into the Anchorprognoses of such patients is difficult to conduct. In this study, we aimed to develop a nomogram model to predict the prognosis of HCC patients with lymph node metastasis. Methods: HCC patients diagnosed with LN metastasis from 2010 to 2015 were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate Cox regression and lasso regression were used to screen prognostic factors. Cox multiple-factor analysis was used to investigate the independent risk factors for survival. We developed a prognostic nomograms using these independent risk factors. The predictive performance of our nomogram model was evaluated according to the concordance index (C-index) and calibration curve. The net clinical benefit was assessed via decision curve analysis (DCA). Patients were divided into different risk groups according to the model. A survival curve was drawn using the Kaplan-Meier method and the difference was compared by the log-rank test. Results: There were 944 patients in the training cohort and 402 patients in the validation cohort. Grade, T stage, surgery to the liver, chemotherapy, radiation recode, AFP, fibrosis score, tumor size group, M stage were selected as independent prognostic factors, and we developed nomograms using these variables. The calibration curves for probability of survival showed good agreement between the prediction by our model and actual observation in both the training and validation groups. DCA indicated that the nomogram had positive net benefits. Conclusions: The nomogram can accurately predict the prognosis of HCC patients with lymph nodes metastasis and provide a reasonable basis for treatment. Keywords: Hepatocellular carcinoma, prognosis, lymph nodes metastasis, prediction model, nomogram

show abstract

Improved survival and higher rates of surgical resection associated with hepatocellular carcinoma in children as compared to young adults

Commander

Cerullo

Arjunji

et al. 2022

Intl Journal of Cancer

View full text Add to dashboard Cite

Hepatocellular adenocarcinoma (HCC) is the second most common primary hepatic malignancy in children with a 5‐year overall survival of 30%. Few studies have examined the similarities and differences between pediatric and adult HCC. This article aims to examine the relationship between tumor characteristics, treatments and outcomes in pediatric and adult patients with HCC. The 2019 National Cancer Database was queried for patients with HCC. Patients were stratified by age: pediatric <21 years (n = 214) and young adults 21 to 40 (n = 1102). Descriptive statistics and chi square were performed. The mean age at diagnosis was 15.5 years (SD 5.6) in the pediatric and 33 years (5.3) in the adult group. Children had a comparable rate of metastasis (30% vs 28%, P = .47) and increased fibrolamellar histology (32% vs 9%). Surgical resection was more common in children compared to adults (74% vs 62%, P < .001), children also had more lymph nodes examined (39% vs 19%, P < .001), positive lymph nodes (35% vs 17%, P = .02) and surgical resection when metastasis were present at diagnosis (46% vs 18%, P < .001). The 1‐, 3‐ and 5‐year overall survival was higher for pediatric patients than adults (81%, 65%, 55%, vs 70%, 54%, 48%). Despite higher prevalence of fibrolamellar histology, greater number of positive lymph nodes and comparable rates of metastasis at diagnosis, children with HCC have improved overall survival compared to adults. Age did not significantly contribute to survivorship, so it is likely that the more aggressive surgical approach contributed to the improved overall survival in pediatric patients.

show abstract

Extrahepatic metastasectomy for hepatocellular carcinoma: Predictors of long‐term survival

Cited by 15 publications

References 0 publications

A practical nomogram from the SEER database to predict the prognosis of hepatocellular carcinoma patients with lymph node metastasis

A practical nomogram from the SEER database to predict the prognosis of hepatocellular carcinoma patients with lymph node metastasis

A practical nomogram predicting the prognosis of hepatocellular carcinoma patients with lymph node metastasis: A population-based analysis

Improved survival and higher rates of surgical resection associated with hepatocellular carcinoma in children as compared to young adults

Contact Info

Product

Resources

About