Extrahepatic Immunologic Manifestations in Chronic Hepatitis C and Hepatitis C Virus Serotypes

Pawlotsky, Jean‐Michel; Roudot-Thoraval, F; Simmonds, Peter; Mellor, Janet; Yahia, Mustapha Ben; André, Cyril; Mc, Voisin; Intrator, L; Zafrani, Elie‐Serge; Duval, J; Dhumeaux, Daniel

doi:10.7326/0003-4819-122-3-199502010-00002

Cited by 315 publications

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“…Moreover, asymptomatic immunologic changes have been reported in this type of infection, such as RF in 71% of patients and ANA in 22% of patients (9).…”

Section: Discussionmentioning

confidence: 97%

“…Latent autoimmune thyroid disease, glomerulonephritis, polymyositis, and pulmonary fibrosis have been reported in association with HCV (5)(6)(7)(8). Lymphocytic sialadenitis has been reported in patients with chronic HCV infection, but the clinical and immunologic status of those patients was not described (9). Retrospective studies have reported the presence of antibodies against HCV in 10% of patients with sicca symptoms, but the actual prevalence of HCV infection associated with Sjogren's syndrome remains a subject of controversy (10).…”

mentioning

confidence: 99%

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Sicca syndrome associated with hepatitis C virus infection

Jørgensen

Legouffe

Perney

et al. 1996

Arthritis & Rheumatism

135

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Objective. To determine the prevalence of hepatitis C virus (HCV) infection in patients with sicca syndrome, and to determine the clinical, immunologic, and genetic characteristics of sicca syndrome associated with HCV.Methods. We conducted a prospective study in a university hospital immunology-rheumatology department. Sixty-two consecutive patients with sicca syndrome according to the European criteria for Sjogren's syndrome were included. HCV infection was diagnosed in patients with positive recombinant immunoblot assay findings and the presence of viral RNA in serum and saliva. Rheumatoid factor (RF), cryoglobulins, antinuclear antibodies, and anti-SS-NSS-B antibodies were sought. HLA typing was performed on all patients.Results. The prevalence of HCV infection in patients with sicca syndrome was 19%. The incidence of neurologic involvement was significantly increased in patients with sicca syndrome associated with HCV infection (24% versus 4%; P c 0.03), as was elevations in transaminase levels (87.5% versus 16%; P < 0.0001). RF and cryoglobulins were more frequent in HCV-positive sicca syndrome patients (62% versus 30%; P C 0.03, and 56% versus 10%; P c 0.001, respectively). In contrast, anti-SS-NSS-B antibodies were present in 38% of HCVnegative sicca syndrome patients, but in only 1 HCVpositive sicca syndrome patient (P c 0.01). No significant difference in HLA type was observed. Viral RNA

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“…Moreover, asymptomatic immunologic changes have been reported in this type of infection, such as RF in 71% of patients and ANA in 22% of patients (9).…”

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Sicca syndrome associated with hepatitis C virus infection

Jørgensen

Legouffe

Perney

et al. 1996

Arthritis & Rheumatism

135

View full text Add to dashboard Cite

show abstract

“…It is well known that some types of cryoglobulinemia are related to HCVinfection (6), and glomerulonephritis without cryoglobulinemia has also been reported to be accompanied with HCVinfection (7). In addition, a high prevalence of rheumatoid factor was reported in HCVpositive patients (8), although its immunological role is not yet well understood. On the other hand, manypatients with chronic hepatitis C have sialoadenitis like sicca syndrome (9).…”

Section: Discussionmentioning

confidence: 99%

Acquired Factor VIII Inhibitor in a Non-Hemophilic Patient with Chronic Hepatitis C Viral Infection.

et al. 1999

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Production of coagulation factor VIII inhibitor is rarely encountered in non-hemophilic patients. A 63-year-old Japanese male suffered from severe bleeding tendency caused by this inhibitor. Although he did not have malignancy or collagen disease, he had chronic hepatitis C virus (HCV)infection. Although HCVis knownto induce production of various autoimmuneantibodies, this may be the first report of a case with both acquired factor VIII inhibitor and HCV infection. (Internal Medicine 38: 283-286, 1999)

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“…The prognosis seems more severe in HBV-PAN, with 35% of deaths compared to 10% in patients with HCV infection. HCV-related vasculitis does not bear specific virologic features in term of genotype, viral load, or phylogenetic analysis (31)(32)(33). In contrast, in HBV-PAN most cases are associated with high levels of viral replication identified by high-serum HBV-DNA levels and hepatitis B antigen positivity, promoting the persistence of viral immune complexes in antigen excess (34).…”

Section: Pan-type Vasculitis Associated With Hcvmentioning

confidence: 99%