Will is a 9-week-old male infant who presents with worsening "yellow" skin and eyes. His mother states that the yellowing of his eyes has fluctuated since birth. She also reports that he has had some yellow-colored stools and golden yellow urine. She denies any signs of lethargy and states that he continues to eat well, taking five ounces of formula every 4 hours. He was born full term via a vaginal delivery and was discharged home on Day of Life 2. Newborn labs revealed a total bilirubin of 11.7 mg/dl and a direct bilirubin of 2.49 mg/dl.
ASSESSMENTExamination reveals an alert, well-nourished infant in no acute distress. His vital signs are stable. They are as follows: temperature, 37.4°C; blood pressure, 152/59 mmHg; heart rate, 128 beats per minute; and respiratory rate, 30 breaths per minute. He is normocephalic, with a flat anterior fontanelle and no cervical lymphadenopathy. His cardiac rate and rhythm are regular. His extremities are warm and well perfused, with a capillary refill of less than 3 seconds. His respirations are nonlabored, and breath sounds are clear. His abdomen is soft, nontender, and nondistended, and no hepatosplenomegaly is appreciated. Generalized jaundice and scleral icterus are noted. Examination of his stool reveals acholic stools (Figure 1).
What is your diagnosis?A. Alagille syndrome B. Choledochal cyst C. Neonatal hepatitis D. Biliary atresiaFIGURE 1. Photograph of acholic stool.