Extragonadal germ cell tumors in Taiwan

Hsu, Yu‐Juei; Pai, Lu; Chen, Yeu‐Chin; Ho, Ching‐Liang; Kao, Woei‐Yau; Chao, D.M.S. Tsu-Yi

doi:10.1002/cncr.10738

Cited by 19 publications

(9 citation statements)

References 33 publications

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“…The other reasons for suboptimal treatment were poor patient compliance, the concomitant presence of other medical conditions and delayed diagnosis/therapy. Recent studies have also reported suboptimal treatment of a significant number of patients in a similar way to the present study [14,15,16,17]. However, these studies did not assess the quality of the chemotherapeutic management in detail.…”

Section: Discussionmentioning

confidence: 39%

Influence of Suboptimal Treatment in Patients with Mediastinal Primary Nonseminomatous Germ Cell Tumors

et al. 2010

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Objectives: The aim of this study was to analyze the prognostic impact of suboptimal treatment in patients with mediastinal primary nonseminomatous germ cell tumor (MNSGCT). Methods: We retrospectively reviewed the clinical data of 23 consecutive MNSGCT patients who were referred to the National Cancer Center Hospital between 1999 and 2007. Optimal treatment was defined as a primary chemotherapy regimen comprising a standard dosage of bleomycin + etoposide + cisplatin or etoposide + ifosfamide + cisplatin with sufficient dose intensity according to the guidelines of the European Germ Cell Cancer Consensus Group. Results: Ten and 13 patients received optimal and suboptimal treatment, respectively. The progression-free survival was statistically different between the patients who received optimal and suboptimal treatment (p = 0.01), and the hazard ratio of the optimal treatment group relative to the suboptimal treatment group was 0.19 (95% CI, 0.04–0.89). Although the overall survival was not statistically different between the 2 patient groups (p = 0.12), the hazard ratio in this regard was 0.36 (95% CI, 0.10–1.38). Conclusions: Patients who receive suboptimal treatment have poor clinical outcomes. Providing treatment after considering evidence-based guidelines may be important for improving the clinical outcomes of MNSGCT patients.

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Section: Discussionmentioning

confidence: 39%

Influence of Suboptimal Treatment in Patients with Mediastinal Primary Nonseminomatous Germ Cell Tumors

et al. 2010

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“…More investigations need to be done to determine whether race is one of the contributors to the poor prognosis of EGCT. Several reports showed that EGCT in mediastina has a worse outcome than EGCT in other sites [15-17]. To our knowledge, there is no report about YST primarily arising in the seminal vesicle.…”

Section: Discussionmentioning

confidence: 90%

“…In Jay P. Shah’s report, African-Americans had poorer survival compared with Caucasians. Yu-juwei Hse [15] reported the treatment results in Chinese patents with nonseminomatous extragonadal germ cell tumor (NSEGCT) are not as good as in patients in Western countries. Saxman et al [16] reported the experience with chemotherapy in Indians with NSEGCT.…”

Section: Discussionmentioning

confidence: 99%

Primary yolk sac tumor of seminal vesicle: a case report and literature review

Yao

Hong

et al. 2012

World J Surg Onc

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BackgroundYolk sac tumor (endodermal sinus tumor) is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor is even rarer and has only been described in case reports. Due to the rarity of the tumors, the appropriately optimal treatment remains unclear. We report a case of yolk sac tumor in the seminal vesicle.CaseA 38-year-old Asian male presented with gross hematuria and hemospermia. Transrectal ultrasound scan showed a solid mass in the left seminal vesicle and the scrotal sonography showed no abnormalities. Bilateral seminal vesicles were resected, and histopathological examination showed a typical pattern of yolk sac tumor (YST). The patient responded poorly to comprehensive treatment of radiotherapy, chemotherapy and surgeries, developed systemic multiple metastases, and died of cachexia one and half years after diagnosis.

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“…7,15 Even with optimal treatments, survival varies among different primary sites and can range from five-year survival of 30-40% in the mediastinal EGCTs to 90% in germinoma of the central nervous system. 4,11,16,17 To date, however, published data on the treatment of EGCTs in Canadian patients are scarce.…”

Section: Introductionmentioning

confidence: 99%

Disease characteristics and survival outcomes of extragonadal primary germ cell tumour in two Canadian tertiary cancer centres

Asif

Alimohamed³

et al. 2016

CUAJ

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Introduction: Extragonadal germ cell tumours (EGCTs) are a heterogeneous group with distinct natural history and responses to treatment modalities. We sought to evaluate characteristics and survival outcomes in men with EGCTs. Methods:We performed a retrospective analysis on a consecutive list of men diagnosed with EGCT in two Albertan cancer centres between 1990 and 2013. Demographic characteristics and outcomes, stratified by primary site, were evaluated. Results: Sixty-nine cases were identified. The median age was 29 (range 15-76) and 48 cases (70%) were non-seminomatous. Twenty-four (35%) belonged to International Germ Cell Cancer Collaborative Group (IGCCCG) favourable risk group, 14 (20%) to intermediate, and 31 (45%) to poor. Thirty (43%) had mediastinal primary (MPs); 29 were treated with first-line bleomycin, etoposide, and cisplatin (BEP). Seventeen (57%) relapses occurred, of which three patients achieved long-term survival. Seventeen (25%) had a central nervous system (CNS) primary, with eight (47%) classic germinoma. Seven (41%) received primary chemotherapy alone; 5 (29%) received primary radiotherapy alone, and 5 (29%) received both. Nineteen (28%) had a retroperitoneal primary (RPs) and received first-line chemotherapy; all but two received BEP and eight (42%) had surgical resection. Three (5%) had other or unknown primary. Five-year overall survival (OS) and disease-free survival for all patients were 56% and 44%, respectively; for MPs, 44% and 34%; for CNS primary, 76% and 53%; for RPs, 58% and 53%. Factors that correlated with decreased OS were elevated alpha fetoprotein (AFP) (p<0.001) or human chorionic gonadotropin (HCG) (p=0.001), lactate dehydrogenase (LDH) levels (p=0.028), bone metastasis (p<0.001), lung metastasis (p<0.001), and IGCCCG poor risk (p=0.001). Conclusions: EGCT is a rare, but important subset of GCT. Patients with EGCTs, despite aggressive treatments, still have poorer outcomes than gonadal primary.

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Extragonadal germ cell tumors in Taiwan

Cited by 19 publications

References 33 publications

Influence of Suboptimal Treatment in Patients with Mediastinal Primary Nonseminomatous Germ Cell Tumors

Influence of Suboptimal Treatment in Patients with Mediastinal Primary Nonseminomatous Germ Cell Tumors

Primary yolk sac tumor of seminal vesicle: a case report and literature review

Disease characteristics and survival outcomes of extragonadal primary germ cell tumour in two Canadian tertiary cancer centres

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