Extragonadal germ cell tumor of the prostate associated with Klinefelter’s syndrome

Abstract

Purpose: We report on a case of extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome. Methods/Results: The patient was a 33-year-old man. A transrectal prostate biopsy suggested combined germ cell tumor (yolk sac tumor + teratoma). Because there was no tumor except from the prostate, we considered this case to be a primary extragonadal germ cell tumor of the prostate. The prostate tumor responded to systemic chemotherapy with cisplatin, vinblastine and bleomycin and elevated lactate dehydrogenase and afetoprotein levels normalized. In addition to chemotherapy, the patient also underwent radiation therapy. Conclusion:The patient has survived for approximately 4 years since the diagnosis.

Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature

“…Although the patient expired from postsurgical complications, autopsy revealed no evidence of tumor [3] . Two further cases demonstrated cisplatin-based therapy as successful [4,5] . In one such case, a neoadjuvant regimen consisting of cisplatin, etoposide and bleomycin resulted in successful debulking of the prostatic tumor.…”

“…The patient relapsed 2 months following treatment and expired shortly thereafter. Another patient expired from relapse within 1 year of receiving two rounds of a cisplat- [2] 1988 CIS, BLEO yes died after 10 months Schriber [3] 1990 CIS, BLEO, VCR, DACT yes died after 4 months Tay [4] 1995 CIS, ETOP, BLEO* yes alive, free of disease Namiki [5] 1999 CIS, VLB, BLEO no alive, with disease Han [12] 2003 in, vinblastine and bleomycin, in addition to two rounds of adriablastin, etoposide, dactinomycin and methotrexate [2] . The first report of a positive response to cisplatinbased therapy was described in 1990 in a patient who received cisplatin, vinblastine, dactinomycin and bleomycin.…”

“…However, subsequent cases revealed evidence that primary EST of the prostate was amenable to chemotherapeutic treatment, especially cisplatin-based therapy [2][3][4][5] . Moreover, there have been three previous cases of metastatic testicular tumors to the prostate, including one incidence of EST [6] .…”

Nonepithelial Tumors and Tumor-Like Lesions of the Prostate Gland

“…A case of a primary prostatic mixed YST/teratoma in a patient with KS has been reported recently. 225 Only two cases of choriocarcinoma of the prostate were reported in the European literature. 226 Michel et al reported a case of teratocarcinoma in a 40-year-old male.…”

Mixed extragonadal germ cell tumor arising from the prostate: a rare combination

“…To date, fewer than 20 cases of primary prostatic malignant GCTs have been described following teratoma, seminoma or EST presentations 123. Only two cases of combined germ cell tumor of the prostate have previously been reported in the English literature 45…”