Extragenital Adenosarcoma Arising in the Pouch of Douglas

Östör, Andrew G.; Nirenberg, Alexander; Ashdown, Martin; Murphy, Denis J.

doi:10.1006/gyno.1994.1151

Cited by 15 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AS was treated by surgical resection in 38/41 (92.7%) patients: 5/38 (13.2%) patients underwent partial resection, and 33/38 (86.8%) underwent total resection. Of the 38 patients who received surgical treatment, 18 (47.4%) underwent resection of only the tumour [5abc, 7, 8, 9, 11, 13, 18, 19d, 20, 22, 23, 24, 30, 34, 36, 37]; four (10.5%) underwent tumour resection, hysterectomy and bilateral salpingo-oophorectomy [ 14 , 28 , 32 , 38 ]; and 16 (42.1%) underwent extensive surgery involving other organs such as the bowel [12, 15, 19a, 19b, 19c, 25, 29, 31, 35] and liver [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

et al. 2018

View full text Add to dashboard Cite

BackgroundExtra-uterine mullerian adenosarcomas have varying biological behaviours depending on the presence of endometriosis or sarcomatous overgrowth. These behaviours manifest according to the tumours’ histological characteristics and sites of origin. The best treatment and oncologic outcome have not been clarified because only a few cases of extra-uterine and extra-ovarian adenosarcoma have been described in the literature. Here, we report a case of primary peritoneal adenosarcoma with sarcomatous overgrowth and review all reported cases of adenosarcomas arising outside of the uterus and outside the ovaries to identify the best treatment options and clarify outcomes.Case presentationA 79-year-old woman was referred to our Department with an abdominal mass resembling a fibroid with a haemorrhage. Her gynaecological history was negative. A transvaginal and transabdominal ultrasound examination revealed a multicystic mass resembling an ovarian tumour arising from the pelvis and extending up to the abdomen. At laparotomy a peritoneal mass arising from Douglas peritoneum was resected. The uterus and adnexa appeared normal, and a supra-cervical hysterectomy with bilateral salpingo-oophorectomy was performed. No macroscopic residual disease was present. Final pathology diagnosed a malignant peripheral nerve sheath tumors with divergent differentiation. Four weeks later a new, multicystic mass was found. Due to the progressive poor condition, the patient died four months after diagnosis. Histological slides were reviewed by external expert pathologists and the final diagnosis was of extra-genital adenosarcoma with sarcomatous overgrowth. Furthermore, we also collected and analysed articles written in English regarding extra-uterine and extra-ovarian adenosarcomas published between January 1974 and October 2016. PubMed was used as a database for this search. Clinical and pathological characteristics, treatments and outcomes were assessed.ConclusionsOnly 41 cases has been reported in literature. Previous endometriosis and sarcomatous overgrowth showed an inverse effect on prognosis. Endometriosis was confirmed to have a positive effect on disease free survival Complete surgical resection is the mainstay of treatment. A worldwide registry is urgently required to collect data to standardize treatment and to obtain reliable data on prognosis.

show abstract

Section: Resultsmentioning

confidence: 99%

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Adenosarcoma should be distinguished from its uncommon benign counterpart, adenofibroma, but the differential diagnosis cannot be established with certainty from curettage or biopsy specimens [8]. …”

Section: Discussionmentioning

confidence: 99%

“…Only two cases of Müllerian adenosarcoma located in the pouch of Douglas, described by Ostor et al [8] have been reported so far (Table 1). …”

Section: Discussionmentioning

confidence: 99%

“…Only two cases arising in the pouch of Douglas are known so far [8]. The recurrence rate and the medium- to long-term survival rate depend on the grade and mitotic index of the stromal component [9,10] and on the presence of sarcomatous overgrowth [11].…”

Section: Introductionmentioning

confidence: 99%

“…The recurrence rate and the medium- to long-term survival rate depend on the grade and mitotic index of the stromal component [9,10] and on the presence of sarcomatous overgrowth [11]. Tumor location is also an important prognostic factor as extragenital tumors have proved to be more aggressive [8,12]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Extragenital Müllerian adenosarcoma with pouch of Douglas location

et al. 2011

View full text Add to dashboard Cite

BackgroundOf all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. Variant that arises in the pouch of Douglas is scarcely mentioned in the medical literature.Case PresentationA 49-year-old para-0 woman, was seen at our OB/GYN-UNIT because she complained vaguely of pelvic pain. She had a mass of undefined nature in the pouch of Douglas. A simple excision of the mass showed low-grade Müllerian adenosarcoma with areas of stromal overgrowth. One and a half year after surgery, at another hospital, a mass was detected in the patient's posterior vaginal fornix and removed surgically. Six months later she came back to our observation with vaginal bleeding and mass in the vaginal fornix. We performed radical surgery. The pathological examination showed recurrent adenosarcoma. Surgical treatment was supplemented by radiation therapy.ConclusionsThe case of Müllerian adenosarcoma reported here is the third known so far in the literature that was located in the pouch of Douglas. To date, only two other such cases have been reported, including one resulting from neoplastic degeneration of an endometriotic cyst.

show abstract

Ascitic fluid cytology of adenosarcoma of the ovary: A case report

Hirakawa

Kobayashi

Miki

et al. 2001

Diagnostic Cytopathology

View full text Add to dashboard Cite

Extrauterine adenosarcoma is very rare and originates in the ovary, adnexa, or myometrium. Cytologic study of ascites is very important to determine clinical staging of malignant ovarian tumors and provide adequate therapy for recurrence. The cytomorphologic features of adenosarcoma have been only rarely described. A 77-yr-old woman visited a hospital with a complaint of lower abdominal pain for 1 mo. A tumor originating from the right adnexa in the pelvis, and involving the rectum, was found in surgery. In the ascitic fluid cytology, a few dispersed tumor cells with large cytoplasm and nuclei were oval-shaped, with nuclear invagination. The chromatin was finely granular; one or two nucleoli were conspicuous. To our knowledge, this is the fifteenth reported case of adenosarcoma of the ovary, and there have been no prior reports describing the cytological features of ascitic fluid cells in adenosarcoma of the ovary.

show abstract

Extragenital Adenosarcoma Arising in the Pouch of Douglas

Cited by 15 publications

References 0 publications

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

Extragenital Müllerian adenosarcoma with pouch of Douglas location

Ascitic fluid cytology of adenosarcoma of the ovary: A case report

Contact Info

Product

Resources

About