Extraembryonic mesoderm cells derived from human embryonic stem cells rely on Wnt pathway activation
Si‐Le Wang,
Gao‐Hui Shi,
Kui Duan
et al.
Abstract:Extraembryonic mesoderm cells (EXMCs) are involved in the development of multiple embryonic lineages and umbilical cord formation, where they subsequently develop into mesenchymal stem cells (MSCs). Although EXMCs can be generated from human naïve embryonic stem cells (ESCs), it is unclear whether human primed ESCs (hpESCs) can differentiate into EXMCs that subsequently produce MSCs. The present report described a three‐dimensional differentiation protocol to induce hpESCs into EXMCs by activating the Wnt path… Show more
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