Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties

Hattesohl, Miguel; Feistel, B; Sievers, Hartwig; Lehnfeld, R.; Hegger, Mirjam; Winterhoff, H.

doi:10.1016/j.phymed.2007.11.027

Cited by 134 publications

(80 citation statements)

References 42 publications

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“…Ethanolic extract of garlic (25,50 and 100 mg/kg) was administered orally for 14 successive days to young Swiss albino mice of either sex and antidepressant-like activity was evaluated employing tail suspension test (TST) and forced swim test (FST) 48 .…”

Section: Morinda Officinalismentioning

confidence: 99%

Untitled

2011

IJPSR

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Depression is a heterogenous mood disorder that has been classified and treated in variety of ways. Although a number of synthetic drugs are being used as standard treatment for clinically depressed patient, they have adverse effects that can compromise the therapeutic treatment .Thus, it is worthwhile to look for antidepressant from plants with proven advantage and favorable benefit to risk ratio. A number of medicinal plants and medicine derived from these plants have shown antidepressant properties by virtue of combined effect of their medicinal constituents. The causes of depression are decreased brain levels of monoamines like noradrenaline, dopamine and serotonin. Therefore, drugs restoring the reduced levels of these monoamines in the brain either by inhibiting monoamine oxidase or by inhibiting reuptake of these neurotransmitters might be fruitful in the treatment of depression. The present review is focused on the medicinal plants and plants based formulations having antidepressant activity in animal studies and in humans.

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Section: Morinda Officinalismentioning

confidence: 99%

Untitled

2011

IJPSR

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“…Como exemplo de algumas espécies podemos citar as do gênero Passifl ora, P. alata Reginatto et al, 2006;Petry et al, 2001), P. edulis Coleta et al, 2006;Reginatto et al, 2006;Silva et al, 2006b;Dhawan et al, 2001c;Petry et al, 2001), P. incarnata (Movafegh et al, 2008, Brown et al, 2007Dhawan et al, 2001a,b,c;Dhawan et al, 2002;2003), P. quadrangularis (de Castro et al, 2007), P. actinia (Lolli et al, 2007) e P. coerulea (Wolfman et al, 1994). Além deste gênero, podemos citar as plantas do gênero Piper, P. methysticum (Amorim et al, 2007;Cordeiro et al, 2005;Garrett et al, 2003;Feltenstein et al, 2003;Rex et al, 2002;Bilia et al, 2002) e P. tuberculatum (Felipe et al, 2007), e as espécies do gênero Valeriana como, V. offi cinalis (Hattesohl et al, 2008;Alexandre et al, 2008;Kennedy et al, 2006;Ortiz et al, 1999) e V. edulis (Oliva et al, 2004).…”

Section: Demais Espéciesunclassified

Plantas medicinais e seus constituintes bioativos: uma revisão da bioatividade e potenciais benefícios nos distúrbios da ansiedade em modelos animais

Sousa¹,

Melo²,

Citó³

et al. 2008

Rev. bras. farmacogn.

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RESUMO:A procura de novos agentes terapêuticos provenientes de plantas medicinais para doenças psiquiátricas tem progredido signifi cativamente na última década. Isso refl ete num grande número de preparações herbárias para as quais o potencial psicoterapêutico tem sido avaliado em diversos modelos animais. O intuito desta revisão é fornecer uma ampla visão das plantas medicinais que apresentam efeitos terapêuticos signifi cantes em modelos animais de doenças psiquiátricas, especifi camente os distúrbios da ansiedade. Um considerável número de constituintes herbários cujos efeitos comportamentais e ações farmacológicas têm sido bem caracterizados podem ser bons candidatos para futuras investigações que podem resultar em uso clínico, merecendo, portanto, uma maior atenção em estudos posteriores.Unitermos: Plantas medicinais, distúrbios da ansiedade, modelos animais de ansiedade. ABSTRACT: "Medicinal plants and their bioactive constituents:A scientifi c review of bioactivity and potential benefi ts in the anxiety disorders in animal models". A search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has progressed signifi cantly in the past decade. This is refl ected in the large number of herbal preparations for which psychotherapeutic potential has been evaluated in a variety of animal models. The aim of this review is to provide an overview of medicinal plants that have signifi cant therapeutic effects in animal models of psychiatric illnesses, specifi cally anxiety disorders. A considerable number of herbal constituents whose behavioral effects and pharmacological actions have been well characterized may be good candidates for future investigations that may result in clinical use, thus deserving increased attention in future studies.

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“…Literature reports clearly evidenced that P. granatum is used to treat chronic anxiety and insomnia 1,8 , while Valeriana officinalis is used for mild sleep disorders and nervous tension 9,10 . Furthermore, anti-anxiety and anti-depressant effects have been observed after Rosmarinus officinalis [11][12][13][14] and Tilia spp 15,16 consumption. L-theanine, one of the tea constituents, has been shown to play a role in reducing stress and decreasing heart rate in chronic anxiety 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

Cerbo

Sechi

Canello

et al. 2017

JoVE

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In dogs, diets are often used to modulate behavioral disturbances related to chronic anxiety and stress caused by intense and restless activity. However, the traditional ways to monitor behavioral changes in dogs are complicated and not efficient. In the current clinical evaluation, a new, simple monitoring system was used to assess the effectiveness of a specific diet in positively modulating the intense and restless activity of 24 dogs of different ages and breeds. This protocol describes how to easily and rapidly evaluate improvement in a set of symptoms related to generalized anxiety by using a specific sensor, a mobile phone app, a wireless router, and a computer. The results showed that dogs treated with specific diets showed significant improvement in the times spent active and at rest after 10 days (p < 0.01 and p < 0.05, respectively). These dogs also showed an overall significant improvement in clinical and behavioral symptoms. A specific sensor, along with its related hardware, was demonstrated to successfully monitor behavioral changes relating to movement in dogs.

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Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties

Cited by 134 publications

References 42 publications

Untitled

Untitled

Plantas medicinais e seus constituintes bioativos: uma revisão da bioatividade e potenciais benefícios nos distúrbios da ansiedade em modelos animais

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

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