Extracts of <i>Coleus forskohlii</i> relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix

Ma, Chaozhi; Zou, Liyuan; Xia, Yu; Tu, Yuhai; Dong, Xue; Yang, Yanfang; Liú, Dan; H, Wu; Dan, Hanxiong; Peng, You

doi:10.1002/jcb.28243

Cited by 13 publications

(9 citation statements)

References 49 publications

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“…In the brain, MMP-9 not only acts as an inflammatory mediator involved in the development of inflammation reactions, but also as a proteolytic enzyme involved in BBB degradation [8,42]. Studies to date have demonstrated that excessive MMP-9 in the brain may aggravate inflammatory reactions and allows for inflammation infiltration into the brain parenchyma since it disrupts the integrity of BBB by attacking the extracellular matrix, basal lamina and TJs in the BBB [10,43,44]. Moreover, MMP-9 is also involved in the cleavage of IL-1β from its precursor to mature form [9].…”

Section: Discussionmentioning

confidence: 99%

Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema

Jin

Wang

Liao

et al. 2019

Cells

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We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. We also found that the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway resulted in MMP-9 overexpression and nuclear factor-κB (NF-κB) activation in mice treated with 1,2-DCE. In this study, we further hypothesized that inflammatory reactions mediated by the p38 MAPK/ NF-κB signaling pathway might be involved in MMP-9 overexpression, blood–brain barrier (BBB) disruption and edema formation in the brain of 1,2-DCE-intoxicated mice. Our results revealed that subacute poisoning by 1,2-DCE upregulates protein levels of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), interleukin-1β (IL-1β), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), inducible nitric oxide synthase (iNOS) and p-p65 in mouse brains. Pretreatment with an inhibitor against p38 MAPK attenuates these changes. Moreover, pretreatment with an inhibitor against NF-κB attenuates alterations in brain water content, pathological indications notable in brain edema, as well as mRNA and protein expression on levels of MMP-9, VCAM-1, ICAM-1, iNOS, and IL-1β, tight junction proteins (TJs), GFAP and Iba-1 in the brain of 1,2-DCE-intoxicated mice. Furthermore, pretreatment with an inhibitor against MMP-9 obstructs the decrease of TJs in the brain of 1,2-DCE-intoxicated mice. Lastly, pretreatment with an antagonist against the IL-1β receptor also attenuates changes in protein levels of p-p38 MAPK, p-p65, p-IκB, VCAM -1, ICAM-1, IL-1β, and Iba-1 in the brain of 1,2-DCE-intoxicated-mice. Taken together, findings from the current study indicate that the p38 MAPK/ NF-κB signaling pathway might be involved in the activation of glial cells, and the overproduction of proinflammatory factors, which might induce inflammatory reactions in the brain of 1,2-DCE-intoxicated mice that leads to brain edema.

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Section: Discussionmentioning

confidence: 99%

Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema

Jin

Wang

Liao

et al. 2019

Cells

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“…Additionally, forskolin has been proven to have immunomodulatory effects in an experimental model of auto-immune encephalomyelitis through interruption of macrophage/microglia activation, and infiltration and production of IFN-γ by CD4 T cells [ 159 ]. Furthermore, there was evidence for the bronchodilator effects of forskolin attributed to suppressing generation of various inflammatory cytokines and chemokines; NFkB‐p65, IL‐4, interleukin-5 (IL‐5), IL‐17 and ICAM‐1 together with downregulation expression of MMP‐9, and tissue inhibitor of metalloproteinase-1 (TIMP‐1) in lung tissue by stabilizing the extracellular matrix [ 160 ]. In addition, forskolin has been shown to possess anti-platelet activity mediated by elevating levels of platelet cAMP [ 161 ].…”

Section: Drugs That Might Affect the Cytokines Storm In Covid-19mentioning

confidence: 99%

Promising drug repurposing approach targeted for cytokine storm implicated in SARS-CoV-2 complications

Shawki

Elsayed

Mantawy

et al. 2021

Immunopharmacology and Immunotoxicology

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A global threat has emerged in 2019 due to the rapid spread of Coronavirus disease (COVID-19). As of January 2021, the number of cases worldwide reached 103 million cases and 2.22 million deaths which were confirmed as the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). This global pandemic galvanized the scientific community to study the causative virus (SARS-CoV2) pathogenesis, transmission, and clinical symptoms. Remarkably, the most common complication associated with this disease is the cytokine storm which is responsible for COVID-19 mortality. Thus, targeting the cytokine storm with new medications is needed to hamper COVID-19 complications where the most prominent strategy for the treatment is drug repurposing. Through this strategy, several steps are skipped especially those required for testing drug safety and thus may help in reducing the dissemination of this pandemic. Accordingly, the aim of this review is to outline the pathogenesis, clinical features, and immune complications of SARS-CoV2 in addition to suggesting several repurposed drugs with their plausible mechanism of action for possible management of severe COVID-19 cases.

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“…In Ayurvedic practice, Anu Taila is used for Nasya processes (nasal drops) to reduce inflammation in nasal passage and respiratory tract. The polyherbal components of Anu Taila, Aegle marmelos ( Nicolis et al, 2009 ; Pynam and Dharmesh, 2018 ; Rajaram et al, 2018 ), Asparagus racemosus ( Gautam et al, 2009 ; Kanwar and Bhutani, 2010 ; Tiwari et al, 2017 ), Aquilaria agallocha ( Yadav et al, 2013b ), Cedrus deodara ( Gupta et al, 2011 ), Cinnamomum verum ( Hagenlocher et al, 2013 ), Coleus vettiveroides ( Ma et al, 2019 ), Cyperus esculentus ( Krichene et al, 2016 ), Cyperus rotundus ( Kamala et al, 2018 ), Desmodium gangeticum ( Yadav et al, 2013a ), Elettaria cardamomum ( Majdalawieh and Carr, 2010 ), Embelia ribes ( Shirole et al, 2015 ), Glycyrrhiza glabra ( Lee et al, 2019 ), Nelumbo mucifera ( Zhao et al, 2010 ), Ocimum sanctum ( Choudhury et al, 2014 ), and Pogostemon cablin ( Yang et al, 2018 ) have anti-inflammatory potential and can ameliorate pro-inflammatory cytokines such as IL-1β, TNF-α, IFN-γ, IP-10, MCP-1, IL-4, and IL-8.…”

Section: Introductionmentioning

confidence: 99%

Comparative retrospective open-label study of ayurvedic medicines and their combination with allopathic drugs on asymptomatic and mildly-symptomatic COVID-19 patients

Balkrishna

Bhatt²,

Singh

et al. 2021

Journal of Herbal Medicine

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Introduction Treatment for COVID-19 was ambiguous in the beginning of the pandemic. At that time, the conventional medical system was grappling to cope with the rapidly spreading pandemic. The potential of Ayurveda, one of the branches of traditional Indian medicine (TIM), with a 5000 year old history, employing medicines derived from plants and other natural sources, against COVID-19 has been explored through a comparative retrospective open-label study. Methods Reported here are the remedial effects of Ayurvedic medicines alone or in combination with Allopathic treatment on 59 asymptomatic or mildly symptomatic COVID-19 patients, across multiple COVID-19 care centers in Ahmedabad, India. The patients were confirmed for COVID-19 infection through RT-qPCR of nasopharyngeal swabs. With informed consents from the patients, the sourced data was divided into ‘Allopathic and Ayurvedic’ [AlloAyur] (n = 41) and ‘Ayurvedic only’[Ayur] (n = 18) groups, based on the type of treatment the patients decided to receive, that is Ayurvedic medicines with Allopathic treatment or Ayurvedic medicines alone, respectively. Ayurvedic medicines included oral doses and nasal drops; the dosage and regime were decided based on the recommendations from Ayurvedic texts. The Allopathic medicines included Azithromycin, Vitamin-C and anti-histamines. Acetaminophen was also administered when necessary, by the attending physician. The patients were observed for symptomatic improvement. Results Primary outcome of this study was the symptomatic relief from COVID-19. Data collected over a period of two months, showed that more patients exhibited symptomatic relief in Ayur goup (83.33%) than in the AlloAyur group (48.78%) within the first 13 days of treatment. No visible adverse effects were observed. This indicated faster and safe symptomatic resolution among those treated with Ayurvedic medicines alone. Conclusion Patients receiving only Ayurvedic medicines on average were symptomatically relieved faster than those receiving Allopathic and Ayurvedic medicines together.

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Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix

Cited by 13 publications

References 49 publications

Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema

Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema

Promising drug repurposing approach targeted for cytokine storm implicated in SARS-CoV-2 complications

Comparative retrospective open-label study of ayurvedic medicines and their combination with allopathic drugs on asymptomatic and mildly-symptomatic COVID-19 patients

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