Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymorphonuclear Leucocytes

Heptinstall, Stan; Williamson, Lorna M.; White, Ann E.; Mitchell, J. R. A.

doi:10.1016/s0140-6736(85)92371-2

Cited by 122 publications

(55 citation statements)

References 7 publications

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“…Although its actions are not well understood, parthenolide exhibits low affinity to 5-HT 2A receptor binding activity and blocks serotonin release from platelets, both of uncertain relevance to migraine headache. 39,40 In addition, it reportedly inhibits the activity of IKK␤ or the p65 binding activity of NF-B. Hehner and colleagues showed that parthenolide inhibits activation of the IKK␤ induced by TNF.…”

Section: Fig 3 Glyceryl Trinitrate (Gtn) Infusion Activates the Nf-bmentioning

confidence: 99%

Nuclear factor‐κB as a molecular target for migraine therapy

Reuter

Chiarugi

Bolay

et al. 2002

Annals of Neurology

162

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Nitric oxide (NO) generated from inducible NO synthase (iNOS) participates in immune and inflammatory responses in many tissues. The NO donor glyceryl trinitrate (GTN) provokes delayed migraine attacks when infused into migraineurs and also causes iNOS expression and delayed inflammation within rodent dura mater. Sodium nitroprusside, an NO donor as well, also increases iNOS expression. Because inflammation and iNOS are potential therapeutic targets, we examined transcriptional regulation of iNOS following GTN infusion and the consequences of its inhibition within dura mater. We show that intravenous GTN increases NO production within macrophages. L-N(6)-(1-iminoethyl)lysine, a selective iNOS inhibitor, attenuates the NO signal, emphasizing the importance of enzymatic activity to delayed NO production. iNOS expression is preceded by significant nuclear factor kappa B (NF-kappaB) activity, as reflected by a reduction in the inhibitory protein-kappa-Balpha (IkappaBalpha) and activation of NF-kappaB after GTN infusion. IkappaBalpha degradation, NF-kappaB activation, and iNOS expression were attenuated by parthenolide (3mg/kg), the active constituent of feverfew, an anti-inflammatory drug used for migraine treatment. These findings suggest that GTN promotes NF-kappaB activity and inflammation with a time course consistent with migraine attacks in susceptible individuals. We conclude, based on results with this animal model, that blockade of NF-kappaB activity provides a novel transcriptional target for the development of anti-migraine drugs.

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Section: Fig 3 Glyceryl Trinitrate (Gtn) Infusion Activates the Nf-bmentioning

confidence: 99%

Nuclear factor‐κB as a molecular target for migraine therapy

Reuter

Chiarugi

Bolay

et al. 2002

Annals of Neurology

162

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“…Several studies have also reported that feverfew is effective as an herbal remedy for arthritis, pain, and migraine (23,26,31,40,46).…”

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confidence: 99%

Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium

Tiuman

Ueda-Nakamura

Cortez³

et al. 2005

Antimicrob Agents Chemother

182

116

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The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium. This isolated compound was identified through spectral analyses by UV, infrared, 1 H and 13 C nuclear magnetic resonance imaging, DEPT (distortionless enhancement by polarization transfer), COSY (correlated spectroscopy), HMQC (heteronuclear multiple-quantum coherence), and electron spray ionization-mass spectrometry. Parthenolide showed significant activity against the promastigote form of L. amazonensis, with 50% inhibition of cell growth at a concentration of 0.37 g/ml. For the intracellular amastigote form, parthenolide reduced by 50% the survival index of parasites in macrophages when it was used at 0.81 g/ml. The purified compound showed no cytotoxic effects against J774G8 macrophages in culture and did not cause lysis in sheep blood when it was used at higher concentrations that inhibited promastigote forms. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis with gelatin as the substrate showed that the enzymatic activity of the enzyme cysteine protease increased following treatment of the promastigotes with the isolated compound. This finding was correlated with marked morphological changes induced by parthenolide, such as the appearance of structures similar to large lysosomes and intense exocytic activity in the region of the flagellar pocket, as seen by electron microscopy. These results provide new perspectives on the development of novel drugs with leishmanicidal activities obtained from natural products.

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“…Feverfew may also have anti-inflammatory action through the inhibition of prostaglandin synthesis and phospholipase A. [78][79][80][81] Several randomized controlled studies have been conducted over the past decades with conflicting results, [82][83][84][85][86][87] including a meta-analysis 87 that did not recommend its use for headaches due to the paucity and low average quality of the existing randomized controlled trials on the subject. Inconsistencies in the results of those studies were probably related to wide variations in the strength of the active ingredient (parthenolide), and differences in the stability of feverfew preparations.…”

Section: Herbal Preparations Feverfew (Tanacetum Pathenium)mentioning

confidence: 99%

Foods and Supplements in the Management of Migraine Headaches

Sun-Edelstein¹,

Mauskop²

2009

The Clinical Journal of Pain

111

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Objective: Although a wide range of acute and preventative medications are now available for the treatment of migraine headaches, many patients will not have a significant improvement in the frequency and severity of their headaches unless lifestyle modifications are made. Also, given the myriad side effects of traditional prescription medications, there is an increasing demand for ''natural'' treatment like vitamins and supplements for common ailments such as headaches. Here, we discuss the role of food triggers in the management of migraines, and review the evidence for supplements in migraine treatment.Methods: A review of the English language literature on preclinical and clinical studies of any type on food triggers, vitamins, supplements, and migraine headaches was conducted.Results: A detailed nutritional history is helpful in identifying food triggers. Although the data surrounding the role of certain foods and substances in triggering headaches is controversial, certain subsets of patients may be sensitive to phenylethylamine, tyramine, aspartame, monosodium glutamate, nitrates, nitrites, alcohol, and caffeine. The available evidence for the efficacy of certain vitamins and supplements in preventing migraines supports the use of these agents in the migraine treatment. Conclusions:The identification of food triggers, with the help of food diaries, is an inexpensive way to reduce migraine headaches. We also recommend the use of the following supplements in the preventative treatment of migraines, in decreasing order of preference: magnesium, Petasites hybridus, feverfew, coenzyme Q10, riboflavin, and alpha lipoic acid.

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Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymorphonuclear Leucocytes

Cited by 122 publications

References 7 publications

Nuclear factor‐κB as a molecular target for migraine therapy

Nuclear factor‐κB as a molecular target for migraine therapy

Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium

Foods and Supplements in the Management of Migraine Headaches

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