Extracts of Centaurea bornmuelleri and Centaurea huber-morathii inhibit the growth of colon cancer cells in vitro

Sarker, Satyajit D.; Shoeb, Mohammad; Çelik, Sezgin; Jaspars, Marcel; Nahar, Lutfun; Lin, Paul Kong Thoo; MacManus, Stephen M.

doi:10.3742/opem.2007.7.4.336

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…Other studies confirmed the antibacterial and antioxidant activity of the methanolic extract of the plant [ 80 ]. Also, it could inhibit the growth of colon cancer cells under in vitro conditions [ 81 ].…”

Section: Resultsmentioning

confidence: 99%

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Diabetes mellitus (DM) is a long-life metabolic disorder, characterized by high blood glucose levels. The hyperglycemic condition generally leads to irreversible nerve injury and vascular damage. Among different types of diabetes, type 2 is more common and has spread all over the world. Although various therapeutic approaches have been developed to control type 2 DM, regulating blood glucose levels has still remained a controversial challenge for patients. Also, most prescription drugs cause different side effects, such as gastrointestinal disorders. Thus, developing novel and efficient antidiabetic agents possessing fewer adverse effects is in high demand. Method. The literature was comprehensively surveyed via search engines such as Google Scholar, PubMed, and Scopus using appropriate keywords. Results. Medicinal plants, both extracts and isolated active components, have played a significant role in controlling the blood glucose levels. Good-to-excellent results documented in the literature have made them a precious origin for developing and designing drugs and supplements against DM. Centaurea spp. have been traditionally used for controlling high blood glucose levels. Also, the antidiabetic properties of different species of Centaurea have been confirmed in recent studies through in vitro assays as well as in vivo experiments. Conclusion. Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.

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Section: Resultsmentioning

confidence: 99%

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Several cytotoxic research projects have been conducted on other species of Centaurea in different cell lines [12,13]. Studies about compounds from C. montana [14], cytotoxic and apoptotic effects of C. ainetensis in HCT-116 colon cell line and animal model [15], effectiveness of C. schischkinii seed extract in colorectal cancer cell line (CaCo-2) [16] and the effects of C. bornmuelleri and C. huber-morathii methanol extracts in CaCo-2 cells indicating the cytotoxic effect [17] are some examples.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic activity of Centaurea albonitens Turrill aerial parts in colon and breast cancer cell lines

et al. 2021

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Background: Cancer is the second cause of death in developed countries. Colon and breast cancers are among the most prevalent ones. Research focusing on finding new natural products with fewer side effects to fight cancer is increasing. Objectives: The present study aimed to evaluate the cytotoxicity of Centaurea albonitens Turrill methanol extract and its fractions against colon and breast cancer cell lines and a normal cell line of bovine kidney cells. Methods: The methanol extract and petroleum ether, chloroform and aqueous fractions were provided from the aerial parts of C. albonitens by maceration method in three days. Each day the solvent was refreshed. Colon (HT-29) and breast (MCF-7) cell lines were treated with the extract/fractions for 48 h for evaluating the cytotoxic activity by MTT assay. The apoptotic induction potential was also evaluated with the Hoechst 33258 staining method. Results: The most considerable effect was reported from the chloroform fraction with IC50 values of 25.6 and 25.1 μg/mL in MCF-7 and HT-29 cells, respectively. In Hoechst staining, condensed chromatin of the apoptotic cells was observed in both cell lines. Conclusion: Centaurea albonites can be suggested for further cancer research studies.

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“…As a part of our ongoing phytochemical and bioactivity studies on the genus Centaurea (Kumarasamy et al, 2003;Middleton et al, 2003;Sarker et al, 2005;2007a;Shoeb et al, 2005;2006;2007a-e;Granger et al, 2009), we now report on the freeradical-scavenging activity, antibacterial property and brine shrimp toxicity of the extracts of the aerial parts of C. persica growing in Turkey.…”

Section: Introductionmentioning

confidence: 92%

“…Shoeb, M., MacManus, S. M., Jaspars, M., Kong-Thoo-Lin, P., Nahar, L., Celik, S. and S. D. Sarker (2007a). Bioactivity of two Turkish Centaurea species, and their major constituents.…”

Section: Shoebmentioning

confidence: 99%

Bioactivity of Centaurea persica boiss. (Asteraceae)

Sarker

Nahar

Gujja

et al. 2012

ARCH BIOL SCI BELGRA

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The free-radical-scavenging property, antibacterial activity and brine shrimp toxicity of petroleum ether (PE), dichloromethane (DCM) and methanol (MeOH) extracts of Centaurea persica, a Turkish medicinal plant, were assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtiter plate based assay, and the brine shrimp lethality assay, respectively. Additionally, the disc diffusion assay was also used to assess antibacterial activity. Only the MeOH extract of C. persica exhibited a significant free-radical-scavenging property in the DPPH assay, with an RC50 value of 0.025 mg/mL. However, in the TLC-based qualitative assay, petroleum ether and DCM extracts showed an extremely low level of free-radical-scavenging property. Among the solid-phase extraction fractions of the MeOH extract, the fractions eluted with 60% and 80% MeOH in water exhibited the highest level of free-radicalscavenging activity (RC50 = 0.010 and 0.015 mg/mL, respectively). While DCM extract showed reasonable antibacterial activity against five out of the nine test strains both in the disc diffusion assay and in the resazurin assay, the MeOH extract was highly active against both Escherichia coli and ampicillin-resistant E. coli strains. Among the solid-phase extraction fractions of the MeOH extract, fractions eluted with 80% MeOH in water and 100% MeOH displayed significant antibacterial potencies against both E. coli species. None of the extracts showed any significant toxicity towards brine shrimps (LD50 = >1.00 mg/mL)

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Extracts of Centaurea bornmuelleri and Centaurea huber-morathii inhibit the growth of colon cancer cells in vitro

Cited by 7 publications

References 18 publications

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Cytotoxic activity of Centaurea albonitens Turrill aerial parts in colon and breast cancer cell lines

Bioactivity of Centaurea persica boiss. (Asteraceae)

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