Extracts of Artemisia abrotanum and Artemisia absinthium inhibit growth of Naegleria fowleri in vitro

Mendiola, Judith; Bosa, Marisela; Perez, Nestor; Hernández, Hilda; Torres, Dinorah

doi:10.1016/0035-9203(91)90165-u

Cited by 11 publications

(8 citation statements)

References 3 publications

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“…The study checked the activity of an ethanolic and an aqueous extract of A. absinthium , containing only the sesquiterpenoid lactone fraction. After applying the diluted extracts onto a suspension of N. fowleri , even a 100% inhibition of protozoal growth was observed, the effect being clearly dependent on the concentration [ 84 ].…”

Section: Biological Activities Confirmed By Scientific Researchmentioning

confidence: 99%

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Szopa

Pajor

Klin

et al. 2020

Plants

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Artemisia absinthium—wormwood (Asteraceae)—is a very important species in the history of medicine, formerly described in medieval Europe as “the most important master against all exhaustions”. It is a species known as a medicinal plant in Europe and also in West Asia and North America. The raw material obtained from this species is Absinthii herba and Artemisiae absinthii aetheroleum. The main substances responsible for the biological activity of the herb are: the essential oil, bitter sesquiterpenoid lactones, flavonoids, other bitterness-imparting compounds, azulenes, phenolic acids, tannins and lignans. In the official European medicine, the species is used in both allopathy and homeopathy. In the traditional Asian and European medicine, it has been used as an effective agent in gastrointestinal ailments and also in the treatment of helminthiasis, anaemia, insomnia, bladder diseases, difficult-to-heal wounds, and fever. Today, numerous other directions of biological activity of the components of this species have been demonstrated and confirmed by scientific research, such as antiprotozoal, antibacterial, antifungal, anti-ulcer, hepatoprotective, anti-inflammatory, immunomodulatory, cytotoxic, analgesic, neuroprotective, anti-depressant, procognitive, neurotrophic, and cell membrane stabilizing and antioxidant activities. A. absinthium is also making a successful career as a cosmetic plant. In addition, the importance of this species as a spice plant and valuable additive in the alcohol industry (famous absinthe and vermouth-type wines) has not decreased. The species has also become an object of biotechnological research.

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Section: Biological Activities Confirmed By Scientific Researchmentioning

confidence: 99%

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Szopa

Pajor

Klin

et al. 2020

Plants

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“…However, in particular, this species has been the subject of numerous studies to test its anti-parasite effects [12]. In Cuba, pharmacological studies have been performed with A. absinthium, including assessment against Trypanosoma b. brucei, T. cruzi, L. infantum, Plasmodium falciparum, Microsporum canis, Candida albicans, Escherichia coli, Staphylococcus aureus [13], Naegleria fowleri [14] and their toxicity to Artemia salina larvae [15]. A homeopathic tincture is commercial available as a phytopharmaceutical preparation, which is used mainly as an antiinflammatory and anti-pyretic [16].…”

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confidence: 99%

Chemistry and Leishmanicidal Activity of the Essential Oil fromArtemisia absinthiumfrom Cuba

Monzote

Piñón

Sculli

et al. 2014

Natural Product Communications

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Historically, natural products have been a rich source of lead molecules in drug discovery. In particular, products to treat infectious diseases have been developed and several reports about potentialities of essential oils (EO) against Leishmania could be found. In this study, we report the chemical characterization, anti-leishmanial effects and cytotoxicity of the EO from Artemisia absinthium L. Chemical analysis revealed the EO to be composed of 18 compounds, 11 of which were identified, accounting for 64.1% of the composition. The main component of the EO was trans-sabinyl acetate, which made up 36.7%. In vitro anti-leishmanial screening showed that the A. absinthium EO inhibited the growth of promastigotes (14.4  3.6 g/mL) and amastigotes (13.4 ± 2.4 g/mL) of L. amazonensis; while cytotoxicity evaluation caused 6 fold higher values than those for the parasites. In a model of experimental cutaneous leishmaniasis in BALB/c mice, five doses of EO at 30 mg/kg by intralesional route demonstrated control of lesion size and parasite burden (p< 0.05) compared with animals treated with glucantime and untreated mice. In conclusion, in vitro and in vivo results showed the potential of EO from A. absinthium as a promising source for lead or active compounds against Leishmania, which could be explored.

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“…A. absinthium is used in Cuban folk medicine as a febrifuge and an antiparasitic (Roig 1974); similar uses have also been reported in other countries (Quinlan et al 2002). Antiprotozoal activity of A. absinthium has been demonstrated against Naegleria fowleri (Mendiola et al 1991), P. falciparum (Rodríguez et al 2006) and Giardia lamblia (Guerra et al 2001). No previous reports could be found of A. absinthium antileishmanial or antitrypanosomal potential, except for essential oils extracted from different Artemisia species showing activity against Leishmania tropica and Leishmania major (Hatimi et al 2001).…”

mentioning

confidence: 99%

In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca DC, Melaleuca leucadendron L and Artemisia absinthium L

Valdés

Martínez

Lizama

et al. 2008

Mem. Inst. Oswaldo Cruz

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Extracts of Artemisia abrotanum and Artemisia absinthium inhibit growth of Naegleria fowleri in vitro

Cited by 11 publications

References 3 publications

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses

Chemistry and Leishmanicidal Activity of the Essential Oil fromArtemisia absinthiumfrom Cuba

In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca DC, Melaleuca leucadendron L and Artemisia absinthium L

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