Extracts fromPelargonium sidoides. Inhibit the Growth of Bacteria and Fungi

Lewu, Francis B.; Grierson, Donald; Afolayan, A. J.

doi:10.1080/13880200600714137

Cited by 19 publications

(13 citation statements)

References 15 publications

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“…According to several workers, water extract usually show little or no activity against bacteria (Koduru et al, 2006;Lewu et al, 2006). This study has also complemented such findings as the water fraction was not active at all the doses against all the bacterial species investigated.…”

Section: Discussionsupporting

confidence: 70%

Antimicrobial Activity of the Solvent Fractions from Bulbine Natalensis Tuber

Yakubu¹,

Mostafa²,

Ashafa³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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Bulbine natalensis Baker has been acclaimed to be used as an antimicrobial agent in the folklore medicine of South Africa without scientific evidence to substantiate or refute this claim. In view of this, the in vitro antimicrobial activity of solvent fractions (ethanol, ethyl acetate, n-butanol and water) from Bulbine natalensis Tuber against 4 Gram positive and 12 Gram negative bacteria as well as 3 fungal species were investigated using agar dilution. The ethanolic extract, n-butanol and ethyl acetate fractions inhibited 75, 87.5 and 100% respectively of the bacterial species in this study. The ethanolic, n-butanol and ethyl acetate fractions produced growth inhibition at MIC range of 1-10, 3-10 as well as 1 and 5 mg/ml respectively whereas the water fraction did not inhibit the growth of any of the bacterial species. Again, it was only the ethyl acetate fraction that inhibited the growth of Shigelli flexneri, Staphyloccus aureus and Escherichia coli. The ethanolic, ethyl acetate and n-butanolic fractions dose dependently inhibited the growth of Aspergillus niger and A. flavus whereas the water fraction produced 100% growth inhibition of the Aspergillus species at all the doses investigated. In contrast, no growth inhibition was produced on Candida albicans. The growth inhibition produced by the solvent fractions of B. natalensis Tuber in this study thus justifies the acclaimed use of the plant as an antimicrobial agent. The ethyl acetate fraction was the most potent.

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Section: Discussionsupporting

confidence: 70%

Antimicrobial Activity of the Solvent Fractions from Bulbine Natalensis Tuber

Yakubu¹,

Mostafa²,

Ashafa³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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“…2B and D). In view of the consistently high demand for wild-crafted Pelargonium sidoides, Lewu et al (2006) determined conditions suitable for clonal propagation. Socioeconomic aspects of wild-crafting Pelargonium sidoides in the Eastern Cape region of South Africa are discussed by Lewu et al (2007a).…”

Section: -2000mentioning

confidence: 99%

A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae)

Brendler

Wyk

2008

Journal of Ethnopharmacology

139

102

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“…Chloramphenicol and streptomycin were used as standards in the experiment. 23,24,25,26 . Due to the nature of Candida albicans, the organism was streaked radially like the bacteria.…”

Section: Preparation Of Extractmentioning

confidence: 99%

Untitled

2013

IJPSR

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The antimicrobial activity as well as phytochemical screening of the hexane, acetone, methanol and water extracts of Clematis brachiata Thunb (Ranunculaceae) leaves was investigated. The agar dilution assay method was used for the evaluation of the antimicrobial activity of extracts against 10 bacteria and four fungal species. The phytochemical screenings were performed by using the standard procedures. The acetone and methanol extracts were active against the 10 bacteria strains with MIC ranging between 1.0 and 3.0 mg/ml, whereas the water extract was only active against two Gram-negative bacterial strains at 10.0 mg/ml. There was no activity from the hexane extract. While there was complete growth inhibition by the acetone and methanol extracts against all the fungal species at 10 mg/ml, the hexane extract was active against all the fungal species except Candida albicans at 10 mg/ml. In contrast, the water extract did not show any activity against the fungal species. Phytochemical screening revealed the presence of phenols, tannin, saponin, flavonoids, terpenoids and glycosidic compounds and could be responsible for the above activities of the extracts. The results of this study support the traditional uses of this plant as antibiotics.

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Extracts fromPelargonium sidoides. Inhibit the Growth of Bacteria and Fungi

Cited by 19 publications

References 15 publications

Antimicrobial Activity of the Solvent Fractions from <em>Bulbine Natalensis</em> Tuber

Antimicrobial Activity of the Solvent Fractions from <em>Bulbine Natalensis</em> Tuber

A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae)

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