Extracts and Sesquiterpene Derivatives from the Red Alga <i>Laurencia chondrioides</i> with Antibacterial Activity against Fish and Human Pathogenic Bacteria

Bansemir, Anne; Just, Natalie; Michalik, Manfred; Lindequist, Ulrike; Lalk, Michael

doi:10.1002/cbdv.200490039

Cited by 36 publications

(28 citation statements)

References 14 publications

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“…Among the Laurencia sesquiterpenes, elatol (59) can be singled out as the metabolite tested for its antimicrobial activity in the highest number of investigations, but the reported results are frequently contradictory, as even against the same strains variable levels of activity have been reported over the years [50,81,135,157,165,166,855,876,877].…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

The Laurencia Paradox: An Endless Source of Chemodiversity

Harizani

Iοannou

Roussis

2016

Progress in the Chemistry of Organic Natural Products 102

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Nature, the most prolific source of biological and chemical diversity, has provided mankind with treatments for health problems since ancient times and continues to be the most promising reservoir of bioactive chemicals for the development of modern drugs. In addition to the terrestrial organisms that still remain a promising source of new bioactive metabolites, the marine environment, covering approximately 70% of the Earth's surface and containing a largely unexplored biodiversity, offers an enormous resource for the discovery of novel compounds. According to the MarinLit database, more than 27,000 metabolites from marine macro- and microorganisms have been isolated to date providing material and key structures for the development of new products in the pharmaceutical, food, cosmeceutical, chemical, and agrochemical sectors. Algae, which thrive in the euphotic zone, were among the first marine organisms that were investigated as sources of food, nutritional supplements, soil fertilizers, and bioactive metabolites.Red algae of the genus Laurencia are accepted unanimously as one of the richest sources of new secondary metabolites. Their cosmopolitan distribution, along with the chemical variation influenced to a significant degree by environmental and genetic factors, have resulted in an endless parade of metabolites, often featuring multiple halogenation sites.The present contribution, covering the literature until August 2015, offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. Since mollusks feeding on Laurencia are, in many cases, bioaccumulating, and utilize algal metabolites as chemical weaponry against natural enemies, metabolites of postulated dietary origin of sea hares that feed on Laurencia species are also included in the present review. Altogether, 1047 secondary metabolites, often featuring new carbocyclic skeletons, have been included.The chapter addresses: (1) the "Laurencia complex", the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; (2) the secondary metabolites, which are organized according to their chemical structures and are classified into sesquiterpenes, diterpenes, triterpenes, acetogenins, indoles, aromatic compounds, steroids, and miscellaneous compounds, as well as their sources of isolation which are depicted in tabulated form, and (3) the biological activity organized according to the biological target and the ecological functions of Laurencia metabolites.

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Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

The Laurencia Paradox: An Endless Source of Chemodiversity

Harizani

Iοannou

Roussis

2016

Progress in the Chemistry of Organic Natural Products 102

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“…Halogenated secondary metabolites from red seaweed Laurencia chondrioides showed anti-bacterial activity against fish and human pathogenic bacteria [43]. There is also evidence that the red seaweed Delisea pulchra effectively avoids a broad spectrum of bacterial infections via its halogenated compounds known as furanones [44].…”

Section: Discussionmentioning

confidence: 99%

Solvent extracts of the red seaweed Gracilaria fisheri prevent Vibrio harveyi infections in the black tiger shrimp Penaeus monodon

Kanjana

Radtanatip

Asuvapongpatana

et al. 2011

Fish & Shellfish Immunology

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“…By enhancing the transcriptional activity of latent HIV-1 without inducing the polyclonal activation of non-infected cells, the viral reservoirs potentially could be purged of the virus. Thus, I3A (5) [155], IDB (57k) [156] and ingenol 3-hexanoate (ingenol-B) [154,157] showed outstanding reactivation properties, fully comparable to CD3/28 antibody stimulation, and, because of a lower toxicity profile when compared to other PKC modulators like bryostatin, all qualified as excellent latency-reversing agents. Thus, I3A (5) [155], IDB (57k) [156] and ingenol 3-hexanoate (ingenol-B) [154,157] showed outstanding reactivation properties, fully comparable to CD3/28 antibody stimulation, and, because of a lower toxicity profile when compared to other PKC modulators like bryostatin, all qualified as excellent latency-reversing agents.…”

Section: Antiviral Activitymentioning

confidence: 99%

“…Reversal of latency is related to the binding of NF-κB and related transcription factors to HIV-1 LTR (long terminal repeat) promoter, with triggering of viral RNA transcription [154]. A remarkable synergism was observed between ingenol-B and histone deacylase inhibitors like SAHA (suberoylanilidenehydroxamic acid), an effect not observed with IDB [157]. A remarkable synergism was observed between ingenol-B and histone deacylase inhibitors like SAHA (suberoylanilidenehydroxamic acid), an effect not observed with IDB [157].…”

Section: Antiviral Activitymentioning

confidence: 99%