Extractives of Mammea americana L. Part II. The 4-phenylcoumarins. Isolation and structure of Mammea A/AA, A/A cyclo D, A/BA, A/AB, and A/BB

Antibacterial activity of crude extracts from Mexican medicinal plants and purified coumarins and xanthones

“…However, this is the first report of antibacterial activity of these six compounds against Escherichia coli and Staphylococcus aureus (MSSA and MRSA). Calophyllum brasiliense and Mammea americana contain other types of coumarins and xanthones (Crombie et al, 1967;Finnegan et al, 1972;Finnegan et al, 1973;Ito et al, 2002), therefore, their antibacterial activity should be studied.…”

Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense

“…1), several of them resulted highly cytotoxic against human epidermoid carcinoma cells (KB) (Guilet et al, 2001a,b). Mammea coumarins are characterized by a simple 5,7-dioxygenated coumarin skeleton bearing a phenyl, or an alkyl chain on C-4, acyl and prenyl (free or cyclized) substituents on either C-6 or C-8 (Crombie and Games, 1966;Crombie and Games, 1967;Crombie et al, 1972). They are common constituents of Mammea and Mesua species (Clusiaceae), but have been only found once in a Calophyllum species (Guilet et al, 2001a,b).…”

Cytotoxic and antimicrobial coumarins fromMammea africana

“…Plants of the family Guttiferae are intriguing targets for phytochemical investigation, not only because of their great structural variability but also because of the diverse biological activities of their characteristic secondary metabolites, which include xanthones, biflavonoids, benzophenones and coumarins (Bennett and Lee, 1989;Locksley and Murray, 1971;Crombie et al, 1967a, b). In earlier studies on the Guttiferae found in Cameroon, prenylated xanthones and biflavonoids with interesting biological activities were isolated from Symphonia globulifera (Nkengfack et al, 2002b, c) and Allanblackia floribunda (Nkengfack et al, 2002a).…”