Extractives from Khaya senegalensis A. Juss

Antifeeding activity of limonoids from Khaya senegalensis (Meliaceae)

“…The structure of the isolated compounds ( 1–12 ) has been established by us ( Abdelgaleil et al., 2000, 2001; Nakatani et al., 2000, 2001) for the first time by using different spectroscopic and chemical means. The structure of compounds ( 13–15 ) was determined by comparing their NMR data with that of another published data ( Adesida et al., 1967, 1971; Adesogan and Taylor , 1968). Although many rings of B,D‐secolimonoids have been isolated, senganolides 3 and 4 were the first report of C‐19 oxygenated compounds in mexicanolides and khayanoside ( 12 ) was also the first occurrence of glycoside in rings B,D‐secolimonoids.…”

“…During our study of limonoids, we have found that the ether and acetone extracts of the stem bark of K. senegalensis , collected in Egypt, have potent antifeeding activity against Spodoptera littoralis . Recently, we have reported the structure of B,D‐secolimonoids of mexicanolides ( Nakatani et al., 2000, 2001) and rearranged phragmalins ( Abdelgaleil et al., 2000, 2001) together with three known methyl angolensates ( Adesida et al., 1967, 1971; Adesogan and Taylor , 1968) from those ether and acetone extracts. In this study we report the antifeeding activity of 15 B,D‐secolimonoids isolated from K. senegalensis .…”

Mexicanolide limonoids with in vitro neuroprotective activities from seeds of Khaya senegalensis

“…As a result, 14 new compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) (Fig. 1), as well as 3 known compounds (15)(16)(17) were obtained from the ethanol (95%) extract.…”

“…A variety of rings B, D-seco limonoids including methyl angolensates, mexicanolides, phragmalins, rearranged phragmalins and other novel types limonoids were reported as the main constituents of these plants. [3][4][5][6][7][8] Previous studies on K. senegalensis were focused on its bark, branches and leaves, but its seeds were ignored. Previous research on the seeds of Meliaceae plants indicated that the chemical composition in them was largely different from the other vegetative organs.…”

Targeting Neuroblastoma by Limonoids from the Underutilized Fruits of Xylocarpus granatum

“…Our previous phytochemical study on the stems of this plant revealed the occurrence of α‐glucosidase inhibitory isomeric corniculatolides [14] (Meliaceae), which are rare D‐series of combretastatins confined to Combretaceace and Aegicerataceae. Herein, we report the isolation, identification of unexplored limonoids such as C‐23 photogedunin epimers ( 1 + 2 ), [15] gedunin ( 3 ), [16] deacetyl gedunin ( 4 ), [17] 7‐deacetyl‐7‐oxogedunin ( 5 ), [18] xyloccensin T ( 6 ), [19] 6‐deoxy destigloylswietenine acetate ( 7 ), [20] odoratone ( 8 ), [21] moluccensin V ( 9 ), [22] 6‐desoxyswietenine ( 10 ), [23] granatumin L ( 11 ), [24] and azadiraindin G ( 12 ) [25] from huge fruit waste (Figure 1) of the mangrove forest, their antiproliferation effect on a panel of four mammalian cancer cells and the molecular mechanism behind the antiproliferative effects of photogedunin epimers (1+2) on IMR‐32 cells.…”