Extractive spectrophotometric determination of Quetiapine fumarate in pharmaceuticals and human urine using calmagite as an ion-pair reagent

Abstract

Quetiapine fumarate (QTF) is an antipsychotic drug belonging to the benzisoxazole derivatives indicated for the treatment of schizophrenia. A sensitive and selective method based on dichloromethane-extractable ion-pair of QTF with calmagite (CGT), which exhibited an absorption maximum at 490 nm, is described. At this wavelength, Beer's law is obeyed over the concentration range of 3.0-30.0 µg ml -1 . The apparent molar absorptivity, limit of detection (LOD) and quantitation (LOQ) values are 1.32×10 4 l mol -1 cm -1 , 0.27 and 0.81 µg ml -1 , respectively. The reaction is extremely rapid at room temperature and the absorbance values remain unchanged up to 19 h. The precision results, expressed as intra-day and inter-day relative standard deviation values, are satisfactory (RSD ≤ 2.2%). The accuracy is satisfactory as well (RE ≤ 2.44%). The method was successfully applied to the determination of QTF in pharmaceuticals and spiked human urine with satisfactory results. No interference was observed from common pharmaceutical adjuvants in tablets. Statistical comparison of the results with the official method showed an excellent agreement and indicated no significant difference in precision.

The Use of Green Spectroscopy for Analysis of Quetiapine

“…There are several spectrophotometric methods for QTF assay [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. A comparison of the three suggested methods with these reported methods was presented in Table S2.…”

“…QTF was analyzed by direct UV spectrophotometric measurement in different solvent media [2][3][4][5][6][7] and second order derivative measurement [8]. Color-producing reactions include the ion-pair complexation with sulphonthalein acidic dyes [9, 10], wool fast blue [11], quinoline yellow dye [12], calmagite [13], ion-association complex with tropaeoline ooo and naphthol blue black [14] and charge transfer complexation reactions [15]. Oxidation based spectrophotometric methods involve using potassium dichromate [16] and known excess of potassium permanganate followed by estimating the unreacted reagent with amaranth dye [17].…”

Biofouling: lessons from nature

“…Other coating examples include self-assembled monolayers (SAMs), which are desirable as they coat the surface with a molecularly thick biocompatible film. This is especially important for applications such as Biomedical Micro/Nano Electromechanical Systems (BioMEMS/NEMS) [35][36][37]146]. Figure 14 shows an orthopaedic hip implant covered with a biocompatible coating designed to control biofouling, wear rate and promote bone growth [147,148].…”

Double shell CdTe/CdS/ZnS quantum dots as a fluorescence probe for quetiapine determination in fumarate quetiapine tablets

“…30 It has been used for the treatment of schizophrenia, bipolar disorder and major depressive disorder. [31][32][33] However, only high performance thin layer chromatography, 34 extractive spectrophotometry 35,36 and high performance liquid chromatography 37 have been reported for the determination of quetiapine in QTF pharmaceutical formulations, and the above methods are either low-sensitivity or time-consuming. Thus, it is necessary to develop rapid, sensitive and accurate methods for the determination of quetiapine.…”