Extraction, Quantification, and Cytokine Inhibitory Response of Bakuchiol in Psoralea coryfolia Linn.

Khuranna, Deepak; Sharma, Shivam; Mir, Showkat R.; Aqil, Mohd.; Ahmad, Ajaz; Rehman, Muneeb U.; Ahmad, Parvaiz; Alwahibi, Mona S.; Elshikh, Mohamed S.; Mujeeb, Mohd

doi:10.3390/separations7030048

Cited by 8 publications

(8 citation statements)

References 36 publications

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“… 14 Other methods (supercritical fluid extraction, pressurized liquid extraction, and microwave-assisted extraction) with much shorter extraction time and lower solvent consumption may be considered for mass extraction of bakuchiol. 14 They may be used on a large scale for cheaper drug development. These methods have also been used to extract natural products, so their efficiency in the extraction of bakuchiol needs to be evaluated.…”

Section: Resultsmentioning

confidence: 99%

Bakuchiol, a natural constituent and its pharmacological benefits

Nizam,

Mahmud,

Ark

et al. 2023

F1000Res

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Background and aims Natural compounds extracted from medicinal plants have recently gained attention in therapeutics as they are considered to have lower Toxicity and higher tolerability relative to chemically synthesized compounds. Bakuchiol from Psoralea corylifolia L. is one such compound; it is a type of meroterpene derived from the leaves and seeds of Psoralea corylifolia plants. Natural sources of bakuchiol have been used in traditional Chinese and Indian medicine for centuries due to its preventive benefits against tumors and inflammation. It plays a strong potential role as an antioxidant with impressive abilities to remove Reactive Oxygen Species (ROS). This review has focused on bakuchiol’s extraction, therapeutic applications, and pharmacological benefits. Methods A search strategy has been followed to retrieve the relevant newly published literature on the pharmacological benefits of bakuchiol. After an extensive study of the retrieved articles and maintaining the inclusion and exclusion criteria, 110 articles were finally selected for this review. Results Strong support of primary research on the protective effects via antitumorigenic, anti-inflammatory, antioxidative, antimicrobial, and antiviral activities are delineated. Conclusions From ancient to modern life, medicinal plants have always been drawing the attention of human beings to alleviate ailments for a healthy and balanced lifestyle. This review is a comprehensive approach to highlighting bona fide essential pharmacological benefits and mechanisms underlying their therapeutic applications.

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Section: Resultsmentioning

confidence: 99%

Bakuchiol, a natural constituent and its pharmacological benefits

Nizam,

Mahmud,

Ark

et al. 2023

F1000Res

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show abstract

“…More sophisticated techniques, including various forms of chromatography, have been developed to extract specific compounds from the plant source. 14 Other methods (supercritical fluid extraction, pressurized liquid extraction, and microwave-assisted extraction) with much shorter extraction time and lower solvent consumption may be considered for mass extraction of bakuchiol. 14 They may be used on a large scale for cheaper drug development.…”

Section: Extraction and Solubility Of Bakuchiolmentioning

confidence: 99%

“…14 Other methods (supercritical fluid extraction, pressurized liquid extraction, and microwave-assisted extraction) with much shorter extraction time and lower solvent consumption may be considered for mass extraction of bakuchiol. 14 They may be used on a large scale for cheaper drug development. These methods have also been used in the extractions of natural products, so their efficiency in the extraction of bakuchiol needs to be evaluated.…”

Section: Extraction and Solubility Of Bakuchiolmentioning

confidence: 99%

Bakuchiol and its pharmacological benefits

et al. 2023

View full text Add to dashboard Cite

Background and aims: Natural compounds extracted from medicinal plants have recently gained attention in therapeutics as they are considered to have lower toxicity and higher tolerability relative to chemically synthesized compounds. Bakuchiol is one such compound; it is a type of meroterpene derived from the leaves and seeds of Psoralea corylifolia plants. Natural sources of bakuchiol have been used in traditional Chinese and Indian medicine for centuries due to its preventive benefits against tumors and inflammation. It plays a strong potential role as an antioxidant with impressive abilities to remove Reactive Oxygen Species (ROS). This review has focused on bakuchiol's extraction, therapeutic applications, and pharmacological benefits. Methods: A search strategy has been followed to retrieve the relevant newly published literature on the pharmacological benefits of bakuchiol. After an extensive study of the retrieved articles and maintaining the inclusion and exclusion criteria, 106 articles were finally selected for this review. Results: Strong support of primary research on the protective effects via antitumorigenic, anti-inflammatory, antioxidative, antimicrobial, and antiviral activities are delineated. Conclusions: From ancient to modern life, medicinal plants have always been drawing the attention of human beings to alleviate ailments for a healthy and balanced lifestyle. This review is a comprehensive approach to highlighting bona fide essential pharmacological benefits and mechanism of action of therapeutic implications.

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“…Furthermore, it possesses anti-inflammatory, anti-bacterial, anti-tumor, hepatoprotective, and caspase-3-dependent apoptosis activity. The cytotoxicity of bakuchiol relates to its DNA polymerase 1 inhibition [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Engineering of “Green” Nanoemulsions for Enhanced Topical Delivery of Bakuchiol Achieved in a Sustainable Manner: A Novel Eco-Friendly Approach to Bioretinol

Lewińska

Domżał-Kędzia

Maciejczyk

et al. 2021

IJMS

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In the present work, we establish novel “environmentally-friendly” oil-in-water nanoemulsions to enhance the transdermal delivery of bakuchiol, the so-called “bioretinol” obtained from powdered Psoralea corylifolia seeds via a sustainable process, i.e., using a supercritical fluid extraction approach with pure carbon dioxide (SC-CO2). According to Green Chemistry principles, five novel formulations were stabilized by “green” hybrid ionic surfactants such as coco-betaine—surfactin molecules obtained from coconut and fermented rapeseed meal. Preliminary optimization studies involving three dispersion stability tests, i.e., centrifugation, heating, and cooling cycles, indicated the most promising candidates for further physicochemical analysis. Finally, nanoemulsion colloidal characterization provided by scattering (dynamic and electrophoretic light scattering as well as backscattering), microscopic (transmission electron and confocal laser scanning microscopy), and spectroscopic (UV–Vis spectroscopy) methods revealed the most stable nanocarrier for transdermal biological investigation. In vitro, topical experiments provided on human skin cell line HaCaT keratinocytes and normal dermal NHDF fibroblasts indicated high cell viability upon treatment of the tested formulation with a final 0.02–0.2 mg/mL bakuchiol concentration. This excellent biocompatibility was confirmed by ex vivo and in vivo tests on animal and human skin tissue. The improved permeability and antiaging potential of the bakuchiol-encapsulated rich extract were observed, indicating that the obtained ecological nanoemulsions are competitive with commercial retinol formulations.

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Extraction, Quantification, and Cytokine Inhibitory Response of Bakuchiol in Psoralea coryfolia Linn.

Cited by 8 publications

References 36 publications

Bakuchiol, a natural constituent and its pharmacological benefits

Bakuchiol, a natural constituent and its pharmacological benefits

Bakuchiol and its pharmacological benefits

Design and Engineering of “Green” Nanoemulsions for Enhanced Topical Delivery of Bakuchiol Achieved in a Sustainable Manner: A Novel Eco-Friendly Approach to Bioretinol

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