Extraction optimization of accelerated solvent extraction for eight active compounds from Yaobitong capsule using response surface methodology: Comparison with ultrasonic and reflux extraction

Ji, Yinghe; Li, Xianhui; Wang, Zhenzhong; Xiao, Wei; Zhang, He; Xiong, Zhili; Zhao, Longshan

doi:10.1016/j.chroma.2020.460984

Cited by 16 publications

(11 citation statements)

References 37 publications

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“…ASE has been used to extract a wide variety of compounds and samples, such as herbal samples, dietary supplements, and nutraceuticals, saving vast amounts of time and solvent [ 19 ]. The elevated temperatures improve the extraction performance due to the increase in the mass transfer effect and the destruction of surface equilibrium [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Extraction of Phenolic Compounds from Fresh Apple Pomace by Different Non-Conventional Techniques

et al. 2021

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Red Delicious apple pomace was produced at laboratory scale with a domestic blender and different non-conventional extraction techniques were performed to isolate phenolic compounds, such as ultrasound-assisted extraction (UAE), ultraturrax extraction (UTE), accelerated solvent extraction (ASE) and pulsed electric field (PEF) extraction pre-treatment. Total phenolic content (TPC) was determined by Folin–Ciocalteu assay. Phloridzin, the main phenolic compound in apples, was determined by chromatographic analysis Q-TOF-LC/MS. The results obtained with these techniques were compared in order to identify the most efficient method to recover polyphenols. The highest value of TPC (1062.92 ± 59.80 µg GAE/g fresh apple pomace) was obtained when UAE was performed with EtOH:H2O (50:50, v/v), while ASE with EtOH:H2O (30:70, v/v) at 40 °C and 50% of flush was the most efficient technique in the recovery of phloridzin. The concentration of the main phenolic compounds ranged from 385.84 to 650.56 µg/g fresh apple pomace. The obtained results confirm that apple pomace represents an interesti-ng by-product, due to the presence of phenolic compounds. In particular, phloridzin could be considered a biomarker to determine the quality of numerous apple products. Therefore, this research could be a good starting point to develop a value-added product such as a functional food or nutraceutical.

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Section: Resultsmentioning

confidence: 99%

Extraction of Phenolic Compounds from Fresh Apple Pomace by Different Non-Conventional Techniques

et al. 2021

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“…As a comprehensive mathematical and statistical method, RSM has been applied to optimize multiple factors [30][31][32], and BBD is a traditional method that is used in the experimental design [33,34]. In the article, the factors of limewater concentration, processing time and solvent volume were listed to optimize the technology of LCSS based on BBD.…”

Section: Discussionmentioning

confidence: 99%

A Simple and Economic Limewater-based Conversion of Spirostanol Saponins: Using Paridis Rhizoma as a case study

Yu¹,

Bu²,

Shen³

et al. 2020

Preprint

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Background Green and economic conversion of spirostanol saponins in the plant is considered as an attracting area in pharmaceutical applications. We aimed to provide a practical paradigm named limewater-based conversion of spirostanol saponins (LCSS), meanwhile, a widely-used traditional Chinese herbal medicine, Paridis Rhizoma (PR), was selected as a case study. Methods Based on single factor experiments, response surface methodology (RSM) using a Box-Behnken design (BBD) was employed to optimize processing time, limewater concentration and solvent volume to obtain a maximum total saponins yield from PR. H1299, A549 and HeLa cell lines was carried out to check pharmacological effect of Crude Paridis Rhizoma (CPR) and Processed Paridis Rhizoma (PPR), and the technology was reconfirmed by another herbal medicine, Anemarrhenae Rhizoma (AR). Results The optimal conditions were: processing time of 24 h, limewater concentration of 0.12% limewater and solvent volume of 60 mL/30 g. Under these conditions, the contents of polyphyllin VII, polyphyllin II, dioscin, gracillin, and polyphyllin I had 1.131 ± 0.448, 1.835 ± 0.479, 1.430 ± 0.550, 1.761 ± 0.571 and 1.668 ± 0.360 times increasing in four batches of PR, which was responsible for the increasing of total spirostanol saponins (TSS) in PPR. In addition, the extracts of PPR exhibited stronger antitumor potential than that of CPR on H1299, A549 and HeLa cell lines based on MTT test and cell scratch test. The efficiency of proposed LCSS was then reconfirmed by Anemarrhenae Rhizome (AR), indicating its capacity in broader application. Conclusion This study depicted a LCSS strategy that may have great potential in achieving effective and economic improvement of spirostanol saponin accumulation in herbal medicines.

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“…At present, the extraction methods of plant extracts include solvent extraction, ultrasonic extraction, and microwave extraction (Ji et al 2020). The solvent extraction method adopts the principle of similarity and compatibility to extract the effective components.…”

Section: Extraction Of Berberinementioning

confidence: 99%

Isolation and identification of the antibacterial compounds in Coptis chinensis for the preservation of wood

Wang

Zhao

et al. 2021

BioRes

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Wood is a biomass material that is easily eroded by wood-rotting fungi. Coptis chinensis is a natural green plant, which has an inhibitory effect on most microorganisms. Based on the highly toxic effects of the currently used wood chemical preservatives on humans, animals, and the environment, Coptis chinensis was selected to perform decay resistance experiments of wood in this paper. The active ingredients with bacteriostatic properties in Coptis chinensis were separated and screened via chemical treatment, and their structure was identified via nuclear magnetic resonance spectroscopy. The primary bacteriostatic components in Coptis chinensis were berberine hydrochloride, palmatine, and jatrorrhizine. The bacteriostatic zone experiment with a single component and different compounds for white-rot and brown-rot fungus were tested by the disc agar diffusion method. The bacteriostatic effect of berberine hydrochloride in a single active fraction was better. The three-fraction compound had the best bacteriostatic effect and was equivalent to alkaline copper quaternary. The natural active bacteriostatic fractions in Coptis chinensis had noticeable inhibitory effects on white-rot fungus (Trametes versicolor (L.) Lloyd) and brown-rot fungus (Gloeophyllum trabeum (Pers.) Murrill). The minimum bacteriostatic concentration was 0.01 g/mL. The results showed that Coptis extracts had potential as a wood protectant.

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Extraction optimization of accelerated solvent extraction for eight active compounds from Yaobitong capsule using response surface methodology: Comparison with ultrasonic and reflux extraction

Cited by 16 publications

References 37 publications

Extraction of Phenolic Compounds from Fresh Apple Pomace by Different Non-Conventional Techniques

Extraction of Phenolic Compounds from Fresh Apple Pomace by Different Non-Conventional Techniques

A Simple and Economic Limewater-based Conversion of Spirostanol Saponins: Using Paridis Rhizoma as a case study

Isolation and identification of the antibacterial compounds in Coptis chinensis for the preservation of wood

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