Extraction ofSantolina insularis essential oil by supercritical carbon dioxide: influence of some process parameters and biological activity

Cherchi, Graziella; Deidda, Delia; Gioannis, Barbara De; Marongiu, Bruno; Pompei, Raffaello; Porcedda, Silvia

doi:10.1002/1099-1026(200101/02)16:1<35::aid-ffj942>3.0.co;2-y

Cited by 44 publications

(21 citation statements)

References 21 publications

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“…Santolina insularis SC CO 2 extracts screened for cytotoxic and antimicrobial activity on VERO cells and on S. aureus and E. coli were found to inhibit these microorganisms with a toxicity activity of 0.18 mg cm 3 [118]. SC CO 2 extracts of Juniperus phoenicea were tested on exponentially growing human CD4 + lymphocytes (MT-4), baby hamster kidney (BHK-21), Madin Darby bos kidney (MDBK) and human cell lines derived from liquid and solid tumor.…”

Section: Antibacterial and Cytotoxic Activitymentioning

confidence: 99%

Supercritical Fluid Extraction of Plant Flavors and Fragrances

2013

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Supercritical fluid extraction (SFE) of plant material with solvents like CO 2 , propane, butane, or ethylene is a topic of growing interest. SFE allows the processing of plant material at low temperatures, hence limiting thermal degradation, and avoids the use of toxic solvents. Although today SFE is mainly used for decaffeination of coffee and tea as well as production of hop extracts on a large scale, there is also a growing interest in this extraction method for other industrial applications operating at different scales. In this review we update the literature data on SFE technology, with particular reference to flavors and fragrance, by comparing traditional extraction techniques of some industrial medicinal and aromatic crops with SFE. Moreover, we describe the biological activity of SFE extracts by describing their insecticidal, acaricidal, antimycotic, antimicrobial, cytotoxic and antioxidant properties. Finally, we discuss the process modelling, mass-transfer mechanisms, kinetics parameters and thermodynamic by giving an overview of SFE potential in the flavors and fragrances arena.

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Section: Antibacterial and Cytotoxic Activitymentioning

confidence: 99%

Supercritical Fluid Extraction of Plant Flavors and Fragrances

2013

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“…It is known in Sardinian folk medicine for its anthelmintic properties. In previous works, Santolina insularis essential oil was isolated and characterized, and its antibacterial and antiviral properties were studied [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

Castangia

Manca

Caddeo

et al. 2015

Colloids and Surfaces B: Biointerfaces

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The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the oil to the skin.Santolina insularis essential oil was obtained by steam distillation, and was predominantly composed of terpenes, the most abundant being β-phellandrene (22.6%), myrcene (11.4%) and curcumenes (12.1%). Vesicles were prepared using phosphatidylcholine, and ethylene or 2 propylene glycol were added to the water phase (10% v/v) to improve vesicle performances as delivery systems. Vesicles were deeply characterized by light scattering, cryogenic transmission electron microscopy and small/wide-angle X-ray scattering, the results showing polyhedral, faceted, unilamellar vesicles of ~115 nm in size. The presence of the glycols improved vesicle stability under accelerated ageing conditions, without changes in size or migration phenomena (e.g., sedimentation and creaming). Confocal laser scanning microscopy images of pig skin treated with Santolina insularis formulations displayed a penetration ability of PEVs greater than that of control liposomes. Moreover, all formulations showed a marked in vitro biocompatibility in human keratinocytes.These findings suggest that the nanoformulation may be of value in enhancing the delivery of Santolina insularis essential oil to the skin, where it can exert its biological activities.

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“…Indeed, these compounds were capable of affecting the integrity of S. aureus plasma membrane and cell wall [69]. The hydrodistillated and supercritical fluid extract of S. insularis exerted antibacterial and antifungal activities against dermatophytes and yeast, especially Cryptococcus neoformans [70,71]. Furthermore, the essential oil decreased the germ tube formation in C. albicans, making it a promising anti-Candida agent [71].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

Sanna

Maxia

Fenu

et al. 2020

Plants

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The last decades have recorded an increase of plant-based drug discovery processes. Indeed, natural products possess a superior chemical diversity as compared to synthetic ones, leading to a renewal in searching for new therapeutic agents from the plant kingdom. In particular, since the structural variety of natural compounds reflects the biodiversity of their source organisms, regions of the world with high biodiversity and endemism deserve particular interest. In this context, Sardinia Island (Italy), with 290 endemic taxa (12% of the total flora), is expected to provide unique and structurally diverse phytochemicals for drug development. Several research groups built up a large program dedicated to the analysis of Sardinian endemic species, highlighting their peculiar features, both in respect of phytochemical and biological profiles. On this basis, the aim of this review is to provide an up-to-date and comprehensive overview on ethnobotanical uses, biological properties and phytoconstituents of Sardinian endemic plants in order to support their beneficial potential and to provide input for future investigations. We documented 152 articles published from 1965 to June 2020 in which a broad range of biological activities and the identification of previously undescribed compounds have been reported, supporting their great value as sources of therapeutic agents.

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Extraction ofSantolina insularis essential oil by supercritical carbon dioxide: influence of some process parameters and biological activity

Cited by 44 publications

References 21 publications

Supercritical Fluid Extraction of Plant Flavors and Fragrances

Supercritical Fluid Extraction of Plant Flavors and Fragrances

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

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