Extraction of trans-resveratrol from red wine and optimization by response surface methodology

Rabesiaka, Mihasina; Rakotondramasy-Rabesiaka, Lovasoa; Mabille, Isabelle; Porte, Catherine; Havet, Jean-Louis

doi:10.1016/j.seppur.2011.06.042

Cited by 15 publications

(12 citation statements)

References 26 publications

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“…Various ratios in the isocratic mode were tested, some of which led to the presence of more than one peak (methanol : acetonitrile 3 : 1 and 1.5 : 1). Consequently, water and acetic acid were introduced as a new mobile phase mixture [ 25 , 26 ]. A few symmetric peaks were achieved with methanol, acetonitrile, water, and acetic acid; however, neither method demonstrated repeatability or accuracy.…”

Section: Resultsmentioning

confidence: 99%

Resveratrol‐Loaded Polymeric Nanoparticles: Validation of an HPLC‐PDA Method to Determine the Drug Entrapment and Evaluation of Its Antioxidant Activity

Lindner

Khalil

Mainardes

2013

The Scientific World Journal

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Poly(lactic acid) (PLA) and PLA-poly(ethylene glycol) (PLA-PEG) nanoparticles containing resveratrol (RVT) were developed, and their antioxidant activity was evaluated. An analytical method using high performance liquid chromatography (HPLC)/photodiode array (PDA) detection was also developed and validated for RVT determination in nanoparticles. The mobile phase consisted of methanol : water (51 : 49, v/v) flowed at 0.9 mL/min, and the PDA detector was set at wavelength of 306 nm. The mean diameter of the nanoparticles varied between 180 and 220 nm, and the encapsulation efficiency of RVT ranged from 60% to 88%. The nanoparticles containing RVT were evaluated for their ability to scavenge the radical (2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt) (ABTS•+). The profile obtained from the PLA nanoparticles containing RVT demonstrated that after 24 h, there was almost no increase in antioxidant activity, which was lower than that of the free RVT and RVT-loaded PLA-PEG nanoparticles. For PLA-PEG nanoparticles, the radical-scavenging activity of RVT was shown to increase with time, and after 48 h, it was similar to that observed with free RVT.

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Section: Resultsmentioning

confidence: 99%

Resveratrol‐Loaded Polymeric Nanoparticles: Validation of an HPLC‐PDA Method to Determine the Drug Entrapment and Evaluation of Its Antioxidant Activity

Lindner

Khalil

Mainardes

2013

The Scientific World Journal

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“…With some modification on the method (Rabesiaka et al, 2011), the retention time of trans-resveratrol from MAE method was 13 min and analysis time was 16 min, but it was different retention time of trans-resveratrol from HRE which was in 8.5 min. Chromatogram of each extract was shown in Fig.…”

Section: Comparison Of Mae Methods By Ethanol and Ilmentioning

confidence: 99%

Comparison of Ionic Liquid-Microwave-Assisted Extraction and MAE of Resveratrol from Melinjo (Gnetum gnemon L.) Seeds

Rachmawati

Ayuningtyas

Mun’im³

2017

J App Pharm Sci

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Purpose: This study investigated the effect of [Bmim]Br microwave assisted extraction (MAE), and MAE methods using ethanol on trans-resveratrol extraction from Melinjo (Gnetum gnemon) seeds. Methods: The three-level response surface methodology was used to optimize extraction conditions for transresveratrol content from Melinjo seeds using MAE method and IL-MAE. Resveratrol content was determined using HPLC, and antioxidant activity was examined by DPPH assay. Results: Compared to the MAE-ethanol method, then the optimum result of IL-MAE was reached with [Bmim]Br concentration 2.5 mol/L; microwave power 10%; and extraction time 10 min with the trans-resveratrol value 0.52 mg/g. The antioxidant activity value of IL-MAE melinjo seed extract was in 82.82% of DPPH inhibition. Conclusion: This IL-MAE method was suitable to apply as an alternative technique to extract the active compound from the plant.

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“…In this extraction procedure, the capacity of benzyl benzoate to extract resveratrol efficiently is essential, while the selectivity for resveratrol over structurally similar stilbenes 18 has the potential to reduce the recovery costs significantly in plant cell culture systems [40].…”

Section: Resveratrol Selectivitymentioning

confidence: 99%

“…However, these need advanced and costly equipment. Furthermore, many different methodologies have been used to optimize extraction processes by maximizing the physical interactions between polyphenols and solvents, e.g., the response surface methodology [18], and Hansen solubility parameters (HSPs) [19]; however, solvent volumes were not reduced.…”

Section: Introductionmentioning

confidence: 99%

Development of a liquid-liquid extraction method of resveratrol from cell culture media using solubility parameters

Balkhi

Mohammad

Tisserant

et al. 2016

Separation and Purification Technology

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The extraction of bioactive compounds, produced by plant cell cultures, directly from their culture medium, which contains other by-products, is a great challenge. Resveratrol extraction from its grapevine cell cultures is considered here as an example to optimize improve the extraction processes from plant cell cultures using solubility parameters.Successive liquid-liquid extraction (LLE) processes were exploited to extract resveratrol from the culture medium with an extraction ratio approaching 100%, high selectivity and minimum amounts of solvents. The calculations of partition coefficients as a function of solubility parameters demonstrated that benzyl benzoate is the most suitable intermediate solvent to extract resveratrol from its aqueous medium. The calculations also illustrated the high ability of methanol and ethanol to extract resveratrol from benzyl benzoate. The physicochemical properties of benzyl benzoate and processing conditions were exploited to separate it from aqueous media and organic solvents. The agitation method, component ratios and extraction time were studied to maximize the extraction yield. Under the best conditions, the recovery of resveratrol from different culture media approached ~100% with a selectivity of ~92%.2 Ultimately, the improved extraction processes of resveratrol are markedly efficient, selective, rapid and economical.

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Extraction of trans-resveratrol from red wine and optimization by response surface methodology

Cited by 15 publications

References 26 publications

Resveratrol‐Loaded Polymeric Nanoparticles: Validation of an HPLC‐PDA Method to Determine the Drug Entrapment and Evaluation of Its Antioxidant Activity

Resveratrol‐Loaded Polymeric Nanoparticles: Validation of an HPLC‐PDA Method to Determine the Drug Entrapment and Evaluation of Its Antioxidant Activity

Comparison of Ionic Liquid-Microwave-Assisted Extraction and MAE of Resveratrol from Melinjo (Gnetum gnemon L.) Seeds

Development of a liquid-liquid extraction method of resveratrol from cell culture media using solubility parameters

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