Extraction of protoporphyrin disodium and its inhibitory effects on HBV-DNA

Chao-pin, LI; Xu, Li-Fa; Liu, Qun-Hong; Zhang, Chao; Wang, Jian; Zhu, Yu-Xia

doi:10.3748/wjg.v10.i3.433

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…As the most common porphyrin derivative, PpIX is a water-soluble sodium salt that can be extracted from hemoglobin. , The characteristic structure of a tetrapyrrole large ring is the photoaction center of PpIX, which has a strong visible light absorption ability . When PpIX is excited by light, part of the PpIX returns to the ground state and part of the PpIX converts energy with the surrounding molecular oxygen in the ground state to produce a large amount of singlet oxygen. , PpIX is widely used in antibacterial, , antitumor, , and biological imaging , and in other fields due to its high photoactivity, low toxicity, high safety, and fast metabolism.…”

Section: Introductionmentioning

confidence: 99%

Light-Responsive Fluorescent Security Ink Based on Calixpyridinium–Protoporphyrin IX Disodium Salt Supramolecular Nanoassemblies

Wang

Liu

Gao

et al. 2023

ACS Appl. Nano Mater.

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In this work, the coordination effects of protoporphyrin IX disodium salt (PpIX) with CuII, FeII, and ZnII were systematically studied, and the host–guest interactions of calixpyridinium with PpIX and the three metalloporphyrins were further explored. The bonding ratio between calixpyridinium and PpIX was different from that between calixpyridinium and the other three metalloporphyrins. The reduction of the electronegativity of PpIX caused by the coordination of metal cations may be the reason for the change of the bonding ratio. The reduction of the electronegativity of PpIX caused by the coordination of metal cations also leads to a weaker host–guest interaction with calixpyridinium. The supramolecular nanoassemblies prepared by the host–guest interactions of calixpyridinium with PpIX and the three metalloporphyrins under alkaline conditions could emit a bright fluorescence due to the pH-dependent luminescence characteristics of calixpyridinium and PpIX. Among calixpyridinium and the three metal ions, calixpyridinium alone had the best effect on promoting the photoactivity of PpIX. Its fluorescence gradually disappeared after being irradiated by an incandescent lamp not only in aqueous solution but also on a filter paper. More interestingly, the supramolecular nanoassemblies formed by calixpyridinium and the photoreaction product of PpIX had a reversible temperature responsiveness, which could lead to a reversible fluorescence on–off control. As a result, this material was successfully applied as an intelligent light-responsive fluorescent security ink.

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