Extraction of prefronto-amygdalar pathways by combining probability maps

Bracht, Tobias; Tüscher, Oliver; Schnell, Susanne; Kreher, Björn W.; Rüsch, Nicolas; Glauche, Volkmar; Lieb, Klaus; Ebert, Dieter; Il’yasov, K. A.; Hennig, Jürgen; Weiller, Cornelius; Elst, Ludger Tebartz van; Saur, Dorothee

doi:10.1016/j.pscychresns.2009.05.001

Cited by 54 publications

(36 citation statements)

References 40 publications

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“…For example, the amygdala increases in volume between the ages of 7.5 and 18.5 years (Schumann et al, 2004). Moreover the amygdala has vast connectivity with several regulatory regions, for example ventral and dorsal pathways connect the amygdala to prefrontal brain regions such as the medial and lateral orbitofrontal cortices, as well as anterior cingulate cortex (ACC) and dlPFC (Bracht et al, 2009;Johansen-Berg et al, 2008). Structural connections between these regions continue to mature during adolescence, resulting in greater topdown control, and strengthening pathways that are called upon routinely (Gee et al, 2013).…”

Section: Page 8 Of 49mentioning

confidence: 99%

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Neurocognitive bases of emotion regulation development in adolescence

Ahmed

Bittencourt-Hewitt

Sebastian

2015

Developmental Cognitive Neuroscience

398

301

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Emotion regulation is the ability to recruit processes to influence emotion generation. In recent years there has been mounting interest in how emotions are regulated at behavioural and neural levels, as well as in the relevance of emotional dysregulation to psychopathology. During adolescence, brain regions involved in affect generation and regulation, including the limbic system and prefrontal cortex, undergo protracted structural and functional development. Adolescence is also a time of increasing vulnerability to internalising and externalising psychopathologies associated with poor emotion regulation, including depression, anxiety and antisocial behaviour. It is therefore of particular interest to understand how emotion regulation develops over this time, and how this relates to ongoing brain development. However, to date relatively little research has addressed these questions directly. This review will discuss existing research in these areas in both typical adolescence and in adolescent psychopathology, and will highlight opportunities for future research. In particular, it is important to consider the social context in which adolescent emotion regulation develops. It is possible that while adolescence may be a time of vulnerability to emotional dysregulation, scaffolding the development of emotion regulation during this time may be a fruitful preventative target for psychopathology.

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Section: Page 8 Of 49mentioning

confidence: 99%

“…Ventral and dorsal pathways connect the amygdala to prefrontal brain regions such as the medial and lateral OFC, as well as ACC and dlPFC (Bracht et al, 2009;Johansen-Berg et al, 2008). It has been linked to both learning and expressing the fear response (LeDoux, 2000) as well as determining saliency of emotional stimuli (Adolphs et al, 2005).…”

mentioning

confidence: 99%

Neurocognitive bases of emotion regulation development in adolescence

Ahmed

Bittencourt-Hewitt

Sebastian

2015

Developmental Cognitive Neuroscience

398

301

View full text Add to dashboard Cite

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“…The uncinate fasciculus is a principal white matter tract connecting the temporal pole and other anterior temporal areas to the inferior region of the frontal lobe (Bracht et al, 2009;Burgel et al, 2006;Catani et al, 2002;Catani and Thiebaut de Schotten, 2008;Ebeling and von Cramon, 1992;Highley et al, 2002;Mori et al, 2002;Petrides and Pandya, 2007;Schmahmann et al, 2007;Sedat and Duvernoy, 1990;Ungerleider et al, 1989). The uncinate fasciculus has been identified as a critical part of the temporal-neocortical memory system (Squire and Zola-Morgan, 1991).…”

Section: Functional Roles Of Specific Regions Of Interestmentioning

confidence: 99%

Diffusion Tensor Imaging of Incentive Effects in Prospective Memory after Pediatric Traumatic Brain Injury

McCauley

Wilde

Bigler

et al. 2011

Journal of Neurotrauma

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Few studies exist investigating the brain-behavior relations of event-based prospective memory (EB-PM) impairments following traumatic brain injury (TBI). To address this, children with moderate-to-severe TBI performed an EB-PM test with two motivational enhancement conditions and underwent concurrent diffusion tensor imaging (DTI) at 3 months post-injury. Children with orthopedic injuries (OI; n=37) or moderate-to-severe TBI (n=40) were contrasted. Significant group differences were found for fractional anisotropy (FA) and apparent diffusion coefficient for orbitofrontal white matter (WM), cingulum bundles, and uncinate fasciculi. The FA of these WM structures in children with TBI significantly correlated with EB-PM performance in the high, but not the low motivation condition. Regression analyses within the TBI group indicated that the FA of the left cingulum bundle (p=0.003), left orbitofrontal WM (p<0.02), and left (p<0.02) and right (p<0.008) uncinate fasciculi significantly predicted EB-PM performance in the high motivation condition. We infer that the cingulum bundles, orbitofrontal WM, and uncinate fasciculi are important WM structures mediating motivation-based EB-PM responses following moderate-to-severe TBI in children.

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“…Within the boundaries of the lower segment of the TS, the uncinate fasciculus connects the temporal lobe with the orbitofrontal region (Bracht et al 2009;Catani and Thiebaut de Schotten 2008). Diffusion tensor imaging (DTI) can readily differentiate these tracts (Catani et al 2002;Catani and Thiebaut de Schotten 2008).…”

Section: Memory Neurobehavioral Sequelaementioning

confidence: 99%

The temporal stem in traumatic brain injury: preliminary findings

Bigler

McCauley

et al. 2010

Brain Imaging and Behavior

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The temporal stem (TS) of the temporal lobe is a major white matter (WM) region containing several major pathways that connect the temporal lobe with the rest of the brain. Because of its location, it may be particularly vulnerable to shear-strain effects resulting from traumatic brain injury (TBI). A case vignette is presented in a patient with severe brain injury and focal TS pathology. Also, 12 severe TBI subjects unselected for TS pathology were compared to demographically matched, neurologically-intact controls using diffusion tensor imaging (DTI) to examine white matter tracts associated with the TS, including the inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), arcuate fasciculus (AF), cingulum bundle (CB) and the uncinate fasciculus (UF). For each tract, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were computed and compared between the two groups and also examined in relationship to memory performance in the TBI subjects. Significant FA and ADC differences were observed in all tracts in the TBI patients compared to controls, with several relationships with memory outcome noted in the IFOF, ILF and AF. Based on these preliminary findings, the potential role of TBI-induced WM disconnection involving the TS is discussed as well as the relationship of TS damage to neurobehavioral outcome. The need for future studies specifically examining the role of TS injury in TBI is emphasized.

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Extraction of prefronto-amygdalar pathways by combining probability maps

Cited by 54 publications

References 40 publications

Neurocognitive bases of emotion regulation development in adolescence

Neurocognitive bases of emotion regulation development in adolescence

Diffusion Tensor Imaging of Incentive Effects in Prospective Memory after Pediatric Traumatic Brain Injury

The temporal stem in traumatic brain injury: preliminary findings

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