“…Two different approaches have been proposed for the mathematical modelling of the supercritical fluid extraction (SFE) of natural substance, those are the empirical model, it can be useful when information on the mass transfer mechanisms and on the equilibrium relationships is missing; however, these models are little more than an interpolation of the experimental results (Barton, Hugher, & Hussein, 1992;Kandiah & Spiro, 1990;Naik, Lentz, & Maheshawari, 1989) and differential mass balance model (Goto, Sato, & Hirose, 1993;Goto, Roy, Kodama, & Hirose, 1998;Reverchon, 1996;Reverchon & Poletto, 1996;Roy et al, 1996). To develop a scaleup procedure from laboratory to pilot and industrial scale, we need mathematical models.…”