Extraction of mangiferin from Mahkota Dewa (Phaleria macrocarpa) using subcritical water

Yadav

et al. 2017

Bioresour. Bioprocess.

341

148

Food waste, a by-product of various industrial, agricultural, household and other food sector activities, is rising continuously due to increase in such activities. Various studies have indicated that different kind of food wastes obtained from fruits, vegetables, cereal and other food processing industries can be used as potential source of bioactive compounds and nutraceuticals which has significant application in treating various ailments. Different secondary metabolites, minerals and vitamins have been extracted from food waste, using various extraction approaches. In the next few years these approaches could provide an innovative approach to increase the production of specific compounds for use as nutraceuticals or as ingredients in the design of functional foods. In this review a comprehensive study of various techniques for extraction of bioactive components citing successful research work have been discussed. Further, their efficient utilization in development of nutraceutical products, health benefits, bioprocess development and value addition of food waste resources has also been discussed.

Section: Subcritical Water Extractionmentioning

confidence: 99%

Food waste: a potential bioresource for extraction of nutraceuticals and bioactive compounds

Yadav

et al. 2017

Bioresour. Bioprocess.

341

148

“…The extract showed highly potent in vitro antioxidant activity [13]. However, another scientific group, Kim et al, reported the extraction of Mgf from Mahkota Dewa employing same methodology, but making use of supercritical fluids [16]. Most commonly employed supercritical fluid is supercritical carbon dioxide (scCO2), as it is documented to be ecologically safe, nontoxic and readily available [17].…”

Section: Source Of Mangiferin: Extraction and Isolationmentioning

confidence: 99%

“…Most commonly employed supercritical fluid is supercritical carbon dioxide (scCO2), as it is documented to be ecologically safe, nontoxic and readily available [17]. The extraction yield from subcritical water method has been found to be quite close to the extraction yield using methanol as the extraction solvent, i.e., 21.7 mg/g [16]. Vrushali Soxhlet extraction which usually requires around 5 h. As per the results obtained, the MTPP method proved to be more proficient and faster for extraction of Mgf [19].…”

Section: Source Of Mangiferin: Extraction and Isolationmentioning

confidence: 99%

Mangiferin: a Promising Anticancer Bioactive

et al. 2016

Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, i.e., oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of Mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of Mangiferin.

TANG [HUMANITAS MEDICINE]

“…A novel lignan named as macronone (26) (Susilawati et al, 2012) and a known lignan, syringaresinol (27) (Lisdawati et al, 2007) were obtained from the ethyl acetate extract of the bark and mesocarp of P. macrocarpa, respectively. The investigation on the chemical constituents of this plant yielded a xanthone and flavonoid compound identified as mangiferin (28) (Kim et al, 2010;Oshimi et al, 2008;Zhang et al, 2006) and kaempferol-3-O-β-D-glucoside (29) (Zhang et al, 2006). Moreover, two sugar molecules known as glucose (30) and sucrose (31) (Simanjutak, 2008;Zhang et al, 2006) were isolated from the aqueous extract of P. macrocarpa fruits.…”

Section: Phytochemical Studiesmentioning

confidence: 99%

The ethnomedicinal, phytochemical and pharmacological properties of Phaleria macrocarpa (Scheff). Boerl.

Othman¹,

Sarker²,

Nahar³

et al. 2014

Phaleria macrocarpa (Scheff.) Boerl. is a dense evergreen tree of the family Thymelaeceae. This plant is popular with the name of Mahkota dewa, which is literally translated as God's Crown. All parts of this plant including fruits, seeds, stem, and leaves have well known therapeutic properties and have been extensively used in traditional medicine for the treatment of various diseases such as cancer, diabetes mellitus, allergies, kidney disorders, blood diseases, stroke, and acne with satisfactory results. Scientific findings on bioactivities of P. macrocarpa also demonstrated different pharmacological properties of various parts of this plant including cytotoxic, antidiabetic, antioxidant, anti-inflammatory, antibacterial, and antihypertensive activities. Phytochemicals studies of P. macrocarpa revealed the presence of several classes of compounds such as benzophenones, terpenoids, xanthones, lignans, acids, and sugars. This review aims to provide a critical overview on botanical description, traditional usage, phytochemicals, and pharmacological activities of P. macrocarpa.