Extraction of Lactic Acid from Water Solution by Amine-Solvent Mixtures

Ratchford, William P.; Harris, Edward; Fisher, C. H.; Willits, C. O.

doi:10.1021/ie50495a052

Cited by 39 publications

(19 citation statements)

References 6 publications

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“…It is clear that each extractant showed poor extraction at pH 6.0, indicating that hexane does not qualify in this instance as a suitable diluent. This result corresponds to other findings that nonpolar diluents are less favorable than polar diluents, as shown in previous studies on the extraction of citric (3) and lactic acids (23). On the other hand, TOPO appeared to extract very well in the vicinity of pH 2.0, suggesting that the combination of TOPO with hexane would be suitable for extractions in fermentations of low optimum pH.…”

Section: Reactive Extraction With Extractants Dissolvedsupporting

confidence: 90%

Solvent Screening for Production of Lactic Acid by Extractive Fermentation

Tong¹,

Hirata²,

Takanashi³

et al. 1998

Separation Science and Technology

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The extraction of lactic acid from aqueous solution by a number of extractants dissolved in different organic diluents was explored over a wide range of pH values. Tri-;i-octylmethylammonium chloride (TOMAC or QCI), dissolved in oleyl alcohol, butyl acetate, and a mixture of hexane and oleyl alcohol, was found to be most appropriate in terms of high extraction capacity and simplicity of operation. Biocompatibility between the extraction reagents and lactic-acid-producing microbes was also examined. The results indicated that TOMAC was highly toxic, and both butyl acetate and hexane exhibited some detrimental effects. However, oleyl alcohol exhibited no toxicity and could, therefore, be considered the most suitable diluent. During extractions with TOMAC concentrations no greater than 0.1 kmolm" 3 , implementation of a cleaning column filled with oleyl alcohol seemed to effectively remove trace amounts of TOMAC dissolved in the fermented broth; extractive fermentation of lactic acid was accomplished, despite a little decline in lactic acid production relative to production obtained for a control experiment. However, higher TOMAC concentrations are desired for better extraction of accumulated lactic acid to reduce its own inhibitory effect. A cleaning column packed with the cation-exchange resin Amberlite IR-120B was more effective. As a result, satisfactory extractive fermentation was achieved, thereby proving the feasibility of efficiently producing lactic acid by extractive fermentation, with TOMAC dissolved in oleyl alcohol as the optimum extraction system.

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Section: Reactive Extraction With Extractants Dissolvedsupporting

confidence: 90%

Solvent Screening for Production of Lactic Acid by Extractive Fermentation

Tong¹,

Hirata²,

Takanashi³

et al. 1998

Separation Science and Technology

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“…Further, lactic acid can be re-extracted and the extractant can be recycled to the fermentation process. Tertiary amines are found to be e ective extractants (Ratchford, Harris, Fisher, & Willits, 1951;King, 1983). Alamine 336 (mixture of C 8 ; C 9 and C 10 tertiary amines) yields a good combination of high K D , very low solubility in water and good regenerability.…”

Section: Introductionmentioning

confidence: 99%

Intensification of enzymatic conversion of glucose to lactic acid by reactive extraction

Wasewar

Pangarkar

Heesink

et al. 2003

Chemical Engineering Science

108

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Lactic acid is an important commercial product and extracting this out of aqueous solution is a growing requirement in fermentation-based industries and recovery from waste streams. The design of an amine extraction process requires (i) equilibrium and (ii) kinetic data for the acid-amine (solvent) system used. Equilibria and kinetics for lactic acid extraction by Alamine 336 in octanol as a diluent have been determined and compared with other diluents studied earlier. An approach for extracting the lactic acid by a long-chain tertiary amine, which is in the dispersed phase as a liquid ion exchanger (LIX), is presented. A mathematical model for slurry phase reactor with glucose in the continuous aqueous phase, the amine with a diluent in the dispersed phase and the immobilized enzyme as the solid catalyst, has been developed using equilibrium and kinetic data for reactive extraction. E ects of various parameters a ecting the conversion of glucose have been discussed. The model has been solved for batch and semi-batch modes. It has been shown that the semi-batch mode yields approximately ÿve times higher productivity than batch mode. ?

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“…Numbers of literature [2±10] have reported on the lactic acid extraction with various aliphatic amines. In the earliest report, on the lactic acid extraction with the aliphatic amines, Rachford et al [4] observed that the secondary and the tertiary amines gave the best results. However, the gel formation interferes with the phase separation in the case of secondary amines.…”

Section: Introductionmentioning

confidence: 99%

Lactic acid extraction with trioctyl amine

Choudhury¹,

Swaminathan²

1998

Bioprocess Engineering

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Lactic acid extraction was carried out with trioctyl amine (TOA) in three diluents. The effect of initial lactic acid concentrations on the extraction ef®ciency was investigated. It was observed that although the percentage extraction remained constant or decreased but the loading ratio was increased in all the cases. The overloading was observed in the case of TOA in methyl isobutyl ketone (MIBK). The extraction of lactic acid was favored at a lower aqueous pH in all the diluents. The improvement of the extraction ef®ciency at a higher aqueous pH ( 6) was achieved by using the modi®ed TOA (treated with HCl) in MIBK. However, the recovery of lactic was very poor in the case of modi®ed TOA in MIBK, although the complete recovery was obtained for untreated TOA.

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Extraction of Lactic Acid from Water Solution by Amine-Solvent Mixtures

Cited by 39 publications

References 6 publications

Solvent Screening for Production of Lactic Acid by Extractive Fermentation

Solvent Screening for Production of Lactic Acid by Extractive Fermentation

Intensification of enzymatic conversion of glucose to lactic acid by reactive extraction

Lactic acid extraction with trioctyl amine

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