Extraction of koumine from Gelsemium Elegans Benth. and its therapeutic effect on collagen-induced arthritis in mice

Li, Zhengfei; Zhang, Jieying; Zhang, Ren; Kuang, Yao

doi:10.1590/fst.10421

Cited by 2 publications

(2 citation statements)

References 22 publications

(21 reference statements)

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“…Such evidence was also demonstrated by an in vivo study in which koumine pre-treatment (4.0 and 8.0 mg/kg, p.o. , for 3 weeks) exhibited a therapeutic effect on CIA in mice through regulation of RORγt/Foxp3 signal pathway and modulation of Th17/Treg immune imbalance 63 .…”

Section: Pharmacological Activitymentioning

confidence: 99%

Recent progress in chemistry and bioactivity of monoterpenoid indole alkaloids from the genus gelsemium : a comprehensive review

Wang

Chen

Gao³

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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Monoterpenoid indole alkaloids (MIAs) represent a major class of active ingredients from the plants of the genus Gelsemium . Gelsemium MIAs with diverse chemical structures can be divided into six categories: gelsedine-, gelsemine-, humantenine-, koumine-, sarpagine- and yohimbane-type. Additionally, gelsemium MIAs exert a wide range of bioactivities, including anti-tumour, immunosuppression, anti-anxiety, analgesia, and so on. Owing to their fascinating structures and potent pharmaceutical properties, these gelsemium MIAs arouse significant organic chemists’ interest to design state-of-the-art synthetic strategies for their total synthesis. In this review, we comprehensively summarised recently reported novel gelsemium MIAs, potential pharmacological activities of some active molecules, and total synthetic strategies covering the period from 2013 to 2022. It is expected that this study may open the window to timely illuminate and guide further study and development of gelsemium MIAs and their derivatives in clinical practice.

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Section: Pharmacological Activitymentioning

confidence: 99%

Recent progress in chemistry and bioactivity of monoterpenoid indole alkaloids from the genus gelsemium : a comprehensive review

Wang

Chen

Gao³

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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show abstract

“…In an anxiety model, koumine demonstrated significant anxiolytic effects at doses of 0.5 mg/kg and 1.5 mg/kg [15]. Therapeutic efficacy against collagen-induced arthritis (CIA) in mice was observed at Koumine doses of 2, 4, and 8 mg/kg [28]. In this study, zebrafish larvae in the 50, 75, and 100 mg/L groups showed obvious malformations such as a shortened body length, pericardial edema, yolk sac edema, and curved tails.…”

Section: Discussionmentioning

confidence: 99%

Toxic Effects of Koumine on the Early-Life Development Stage of Zebrafish

Wang,

Leng,

Tian

et al. 2023

Toxics

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Koumine is one of the most abundant alkaloids found in Gelsemium elegans, and it has a wide range of pharmacological effects including antitumor, anti-inflammatory, analgesic treatment effects, and antianxiety. However, its high toxicity and unclear mechanism of action have greatly limited the medicinal development and use of koumine. We investigated the toxic effects of koumine on the developmental toxicity and behavioral neurotoxicity of zebrafish embryos and larvae. Embryos at 6 h postfertilization (hpf) were exposed to 12.5, 25, 50, 75, and 100 mg/L of koumine until 120 hpf. Koumine affected the hatching and heartbeats of the embryos. The morphological analysis also revealed many abnormalities, such as shortened bodies, yolk sac edemas, tail malformations, and pericardial edemas. To identify the neurotoxicity of koumine, the behavior of the larvae was measured. Koumine at 50 and 100 mg/L affect the escape response. The embryos exhibited uncoordinated muscle contractions along the body axis in response to touch at 36 hpf. More importantly, we found that the neurotoxicity of koumine is mainly caused by influencing the ACh content and the activity of AChE without impairing motor neuron development. A comprehensive analysis shows that a high concentration of koumine has obvious toxic effects on zebrafish, and the safe concentration of koumine for zebrafish should be less than 25 mg/L. These results will be valuable for better understanding the toxicity of koumine and provide new insights into the application of koumine.

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Extraction of koumine from Gelsemium Elegans Benth. and its therapeutic effect on collagen-induced arthritis in mice

Cited by 2 publications

References 22 publications

Recent progress in chemistry and bioactivity of monoterpenoid indole alkaloids from the genus gelsemium : a comprehensive review

Recent progress in chemistry and bioactivity of monoterpenoid indole alkaloids from the genus gelsemium : a comprehensive review

Toxic Effects of Koumine on the Early-Life Development Stage of Zebrafish

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