Extraction of hydroxycinnamic acids (ferulic and p-coumaric) from rice straw alkaline black liquor using Pluronic F-127 for potential applications in the cosmetics industry

Maia, Alana M.M.; Pessoa-Junior, Adalberto; Roberto, Inês C.

doi:10.1016/j.indcrop.2023.116914

Cited by 4 publications

(2 citation statements)

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“…It has been previously reported that HCAs play a crucial role in stimulating skin cell proliferation, besides promoting collagen synthesis and exhibiting antimicrobial activity [ 7 , 39 , 40 , 41 , 42 ]. These attributes not only suggest their efficacy in maintaining skin health under normal conditions but also their potential in treating several skin disorders (e.g., acne, dermatitis, eczema, psoriasis).…”

Section: Resultsmentioning

confidence: 99%

“…On the contrary, the repair capacity of Se-glycoconjugates 4b, and 5b, enhanced by increasing the compound concentration, proved to be similar to the corresponding HCA even at lower doses. It has been previously reported that HCAs play a crucial role in stimulating skin cell proliferation, besides promoting collagen synthesis and exhibiting antimicrobial activity [7,[39][40][41][42]. These attributes not only suggest their efficacy in maintaining skin health under normal conditions but also their potential in treating several skin disorders (e.g., acne,…”

Section: Wound Healing Properties On Hacat Cell Linementioning

confidence: 99%

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Innovative Cosmeceutical Ingredients: Harnessing Selenosugar-Linked Hydroxycinnamic Acids for Antioxidant and Wound-Healing Properties

Cimmino,

De Nisco,

Piccolella

et al. 2024

Antioxidants

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Selenosugars are gaining growing interest due to their antioxidant efficacy, and their ability to inhibit glycosidases, repair skin tissue or reduce endothelial dysfunction. Among selenosugars, those in which selenium replaces heterocyclic oxygen in a 5-membered sugar were our focus, and their coupling with phenolic compounds appears to be a strategy aimed at producing new compounds with enhanced antioxidant efficacy. In this context, the Mitsunobu reaction has been advantageously explored to obtain trans-p-coumaroyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose, trans-caffeoyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose, and trans-feruloyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose. These compounds underwent removal of the iso-propylidene group, to provide the corresponding hydroxycinnamoyl-1,4-deoxy-4-seleno-d-ribose. All compounds were characterized by Nuclear Magnetic Resonance (NMR) spectroscopy and High-Resolution Mass Spectrometry (HRMS). This latter technique was pivotal for ensuing cellular metabolomics analyses. In fact, after evaluating the anti-radical efficacy through 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods, which underline the massive role of the phenolic moiety in establishing efficacy, the compounds, whose cytotoxicity was first screened in two highly oxidative-stress-sensitive cells, were tested for their wound healing properties towards human HaCaT keratinocytes cells. Caffeoyl- and feruloyl selenosugars exerted a dose-dependent repair activity, while, as highlighted by the metabolomic approach, they were poorly taken up within the cells.

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