Extraction of ecdysteron-80 from Serratula coronata L. and assessment of its pharmacological action. Part I. Adaptogenic, gastroprotective, thermoprotective, and antihypoxic activity

Abstract

A method for extracting ecdysteroids from Serratula coronata L. for the new phytopreparation Edcysterone-80 is proposed. Experiments on white rats established that this preparation has pronounced adaptogenic, antihypoxic, gastroprotective, and thermoprotective properties. Results of this study can be applied both in basic research and in the development of production technology for the new pharmaceutical preparation based on ecdysteroids of Serratula coronata.Preparations of plant origin that have a broad spectrum of biological activity can be used for prolonged periods without significant side effects. Therefore, they are used more and more not only for treating acute human pathologies but also for prevention and management of several serious chronic diseases. They are not replaced by synthetic drugs but are combined with them for complex therapy.A new drug of plant origin, Ecdysteron-80, is an agent that can supplement the list of such preparations. It contains phytoecdysteroids from Serratula coronata L. (henceforth S. coronata), including 20-hydroxyecdysone ( Fig. 1), which is most often found in plants and exhibits pronounced adaptogenic [1] and hepatoprotective activity [2], in addition to 25S-inocosterone and á-ecdysone. Herein we report a standard method for preparing this drug and its adaptogenic, antihypoxic, gastoprotective, and thermoprotective activity in laboratory animals.

Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

“…The results obtained before and after the application of the cream are presented in Figure 4. There are scientific reports which have suggested that phytoecdysteroids have antiinflammatory and antioxidant properties as well as a positive effect on metabolic diseases, infectious diseases and physical and mental weakness [3,8,11,12,[14][15][16][17][18]31]. Rosselli et al have shown that ecdysones have cytotoxicity potential against rat C6 glioma cells [32].…”

“…The compounds and materials in which they play a dominant role are very promising for phytotherapy [ 7 , 8 , 9 , 10 ]. Phytoecdysteroids have a positive effect on hypercholesterolemia, hyperglycemia, hypotension, infectious diseases and physical and mental weakness [ 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Puri et al have found that 20-beta-hydroxyecdysone is efficient in the prevention of hot flushes in ovariectomized rats [ 19 ].…”

“…Puri et al have found that 20-beta-hydroxyecdysone is efficient in the prevention of hot flushes in ovariectomized rats [ 19 ]. Several scientific reports have suggested the use of phytoecdysteroids as a supplement in the treatment of several diseases of the cardiovascular system [ 11 , 12 , 13 , 14 , 15 , 17 ]. A positive effect of phytoecdysteroids on human skin, including wound healing activity, has been postulated.…”

Preparation and Analysis of the NMR Spectra of the Pharmaceutical Substance«oose-11,12,13»

“…1), found in plants such as Rhaponticum carthamoides, Serratula coronata, and Spinacia oleracea [6]. The prospect of studying the mechanism of action of 20 E is due to the lack of toxicity, and a manifestation of the tonic, anabolic, stress protective, gastroprotective, antihypoxic, and adaptogenic effects [7][8][9][10].…”

Ecdysterone and its Activity on some Degenerative Diseases

“…Besides these, increase in lactation, improvement of wound healing and epidermis regeneration was determined [10][11][12]37,38]. Various compositions of patented preparations have been designed for the prevention of rapid ageing, modulation of the course of diseases associated with old age, influence on obesity, atherosclerosis, hypertension (metabolic syndrome), complaints associated with menopause, andropause, and skin defects related to old age [39][40][41][42][43][44][45][46]. All these make ecdysterone seem like a universal medicinal substance, but this impression is not unique, as, for example flavonoids also interfere with the activity of a wide range of enzymatic systems.…”