Extraction of curcuminoids fromCurcuma longa: comparative study between batch extraction and novel three phase partitioning

Separation and purification of curcumin using novel aqueous two-phase micellar systems composed of amphiphilic copolymer and cholinium ionic liquids

“…In this sense, commercially available crude CCM contains significant amounts of structurally similar compounds, known as curcuminoids. This class of bioactive compounds is mostly comprised by three fundamental components, namely, CCM (≈ 75 wt%), demethoxycurcumin (DMC, ≈ 10-25 wt%), and bisdemethoxycurcumin (BDMC, ≈ 5 wt%), included in the diferuloylmethane group of phenolic compounds [26,46]. The three major curcuminoids are structurally very similar, distinguished only by (the presence/absence of) a methoxy functional group on each of the aromatic rings [18].…”

“…Regarding the purification of curcuminoids, several promising downstream processing platforms have been proposed in the last 5 years [18,26,[46][47][48][49][50]. Despite of good CCM recovery yields and purification factors, most previous studies applied very energetic operations, like subcritical solvent extraction [47], cooling crystallization [46], ultrasound-assisted methods [49,50] or combining multiple, timeconsuming and laborious stages [18,26]. The high recovery/purification performances together with the milder processing conditions (mild temperatures and VOCs-free) make these Pluronic F68/water + ILsbased ATPMS very interesting platforms for the purification of CCM from C. longa L., at least, to replace some of the more energy-consuming and environmentally heavier current downstream units.…”

“…In order to gather insights on how to design selective Pluronic F68 ATPMS-mediated downstream processes, the CCM stability (in the presence of phase-forming components) and partition using these ATPMS were evaluated. CCM, a yellow colored crystalline polyphenol, was chosen for the partition studies, because it is one of the major curcuminoids found in C. longa L. (typically about 75% [26]), with very relevant challenges regarding its extraction/ purification. Additionally, CCM has a poor solubility in aqueous environments, representing an interesting model biomolecule for the development of alternative downstream processes for the purification of hydrophobic bioactive compounds of pharmaceutical interest.…”

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

“…The various developed methods aim to decrease the amount of organic solvents used in the extraction methods and to decrease time required for the multi-step extraction and post-extraction procedures, including separation of curcumin from its analogs. Additionally, they aim to find a more selective extraction method, with high quality yield for food and therapeutic purposes, that proves to be a cost-effective method [13,20,[22][23][24]26].…”

“…Additionally, curcumin initiated Fas-mediated apoptotic pathway in HT-29 colon cancer via caspase 8 activation [32], and it was found to upregulate Bax expression and suppress Bcl- Curcumin was extracted and isolated for the first time by Vogel in the 19th century [15,[17][18][19]. Application of various conventional methods for the extraction of curcuminoids from natural sources involves organic solvents extraction, steam distillation, hot and cold percolation, use of alkaline solution [13], and use of hydrotrope [20]. Moreover, several advanced methods have been also studied, such as supercritical fluid extraction, which has the advantage of being free from organic solvents, ultrasonic and microwave-assisted extraction, and enzyme-assisted extraction [18,21,22].…”